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F2NV13

- RNC_TRES6

UniProt

F2NV13 - RNC_TRES6

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Protein

Ribonuclease 3

Gene

rnc

Organism
Treponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461MagnesiumBy similarity
Active sitei50 – 501Sequence Analysis
Metal bindingi128 – 1281MagnesiumBy similarity
Active sitei131 – 1311By similarity
Metal bindingi131 – 1311MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTSUC869209:GHSS-155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:Tresu_0151
OrganismiTreponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Taxonomic identifieri869209 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000006852: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Ribonuclease 3PRO_0000416614Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 142137RNase IIIAdd
BLAST
Domaini272 – 34170DRBMAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.Curated

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2NV13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRQDIGFVQ SSINYQFKNL QLLEQAFTRK SYSEEHPELQ NNEVLEFYGD
60 70 80 90 100
EILDFFVTKM MYKRFSRILN NELVSEKNEG ELTKLKSILV SKESLARCMY
110 120 130 140 150
NIGFSKFLYL GKSDEKNEVY KSKSVNEDLF EAIIGAVAAD CDWNYEKLEK
160 170 180 190 200
VCRTMLDMET TNGYLALLVK EKSHRLGFGE PCYRPFAWQT DNPEDWQSDN
210 220 230 240 250
LFNMGIGFGG FGSTSKNPKT GKHEYGIQVG ENKFTGIGDG IAQAKLNAEQ
260 270 280 290 300
KAYHFLIQEE IKQQFQNLDY TNPASTLHEL FQKKVIMEVR YEFNEYHDEN
310 320 330 340 350
GNPIWNCKAI LEGYGTFEAD NASKKQVKQD ASLKLLKFIA KTKIEQTEKW
360
EIPTFYHGMA RIWHDEGKI
Length:369
Mass (Da):42,826
Last modified:May 31, 2011 - v1
Checksum:i6657D14A15ED1B13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002631 Genomic DNA. Translation: AEB13117.1.
RefSeqiYP_004364414.1. NC_015385.1.

Genome annotation databases

EnsemblBacteriaiAEB13117; AEB13117; Tresu_0151.
GeneIDi10430238.
KEGGitsu:Tresu_0151.
PATRICi54426797. VBITreSuc166698_0157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002631 Genomic DNA. Translation: AEB13117.1 .
RefSeqi YP_004364414.1. NC_015385.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB13117 ; AEB13117 ; Tresu_0151 .
GeneIDi 10430238.
KEGGi tsu:Tresu_0151.
PATRICi 54426797. VBITreSuc166698_0157.

Phylogenomic databases

KOi K03685.

Enzyme and pathway databases

BioCyci TSUC869209:GHSS-155-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome of chromosome of Treponema succinifaciens DSM 2489."
    Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.
    , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33096 / DSM 2489 / 6091.

Entry informationi

Entry nameiRNC_TRES6
AccessioniPrimary (citable) accession number: F2NV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3