Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease 3

Gene

rnc

Organism
Treponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461MagnesiumBy similarity
Active sitei50 – 501Sequence Analysis
Metal bindingi128 – 1281MagnesiumBy similarity
Active sitei131 – 1311By similarity
Metal bindingi131 – 1311MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTSUC869209:GHSS-155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:Tresu_0151
OrganismiTreponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Taxonomic identifieri869209 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000006852: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Ribonuclease 3PRO_0000416614Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 142137RNase IIIAdd
BLAST
Domaini272 – 34170DRBMAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.Curated

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2NV13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRQDIGFVQ SSINYQFKNL QLLEQAFTRK SYSEEHPELQ NNEVLEFYGD
60 70 80 90 100
EILDFFVTKM MYKRFSRILN NELVSEKNEG ELTKLKSILV SKESLARCMY
110 120 130 140 150
NIGFSKFLYL GKSDEKNEVY KSKSVNEDLF EAIIGAVAAD CDWNYEKLEK
160 170 180 190 200
VCRTMLDMET TNGYLALLVK EKSHRLGFGE PCYRPFAWQT DNPEDWQSDN
210 220 230 240 250
LFNMGIGFGG FGSTSKNPKT GKHEYGIQVG ENKFTGIGDG IAQAKLNAEQ
260 270 280 290 300
KAYHFLIQEE IKQQFQNLDY TNPASTLHEL FQKKVIMEVR YEFNEYHDEN
310 320 330 340 350
GNPIWNCKAI LEGYGTFEAD NASKKQVKQD ASLKLLKFIA KTKIEQTEKW
360
EIPTFYHGMA RIWHDEGKI
Length:369
Mass (Da):42,826
Last modified:May 31, 2011 - v1
Checksum:i6657D14A15ED1B13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002631 Genomic DNA. Translation: AEB13117.1.
RefSeqiWP_013700428.1. NC_015385.1.
YP_004364414.1. NC_015385.1.

Genome annotation databases

EnsemblBacteriaiAEB13117; AEB13117; Tresu_0151.
GeneIDi10430238.
KEGGitsu:Tresu_0151.
PATRICi54426797. VBITreSuc166698_0157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002631 Genomic DNA. Translation: AEB13117.1.
RefSeqiWP_013700428.1. NC_015385.1.
YP_004364414.1. NC_015385.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB13117; AEB13117; Tresu_0151.
GeneIDi10430238.
KEGGitsu:Tresu_0151.
PATRICi54426797. VBITreSuc166698_0157.

Phylogenomic databases

KOiK03685.

Enzyme and pathway databases

BioCyciTSUC869209:GHSS-155-MONOMER.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of chromosome of Treponema succinifaciens DSM 2489."
    Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.
    , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33096 / DSM 2489 / 6091.

Entry informationi

Entry nameiRNC_TRES6
AccessioniPrimary (citable) accession number: F2NV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 31, 2011
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.