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F2NV13

- RNC_TRES6

UniProt

F2NV13 - RNC_TRES6

Protein

Ribonuclease 3

Gene

rnc

Organism
Treponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.

    Cofactori

    Mg2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi46 – 461MagnesiumBy similarity
    Active sitei50 – 501Sequence Analysis
    Metal bindingi128 – 1281MagnesiumBy similarity
    Active sitei131 – 1311By similarity
    Metal bindingi131 – 1311MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciTSUC869209:GHSS-155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3 (EC:3.1.26.3)
    Alternative name(s):
    Ribonuclease III
    Short name:
    RNase III
    Gene namesi
    Name:rnc
    Ordered Locus Names:Tresu_0151
    OrganismiTreponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
    Taxonomic identifieri869209 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000006852: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Ribonuclease 3PRO_0000416614Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 142137RNase IIIAdd
    BLAST
    Domaini272 – 34170DRBMAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RNase III domain.Curated

    Phylogenomic databases

    KOiK03685.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2NV13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRQDIGFVQ SSINYQFKNL QLLEQAFTRK SYSEEHPELQ NNEVLEFYGD    50
    EILDFFVTKM MYKRFSRILN NELVSEKNEG ELTKLKSILV SKESLARCMY 100
    NIGFSKFLYL GKSDEKNEVY KSKSVNEDLF EAIIGAVAAD CDWNYEKLEK 150
    VCRTMLDMET TNGYLALLVK EKSHRLGFGE PCYRPFAWQT DNPEDWQSDN 200
    LFNMGIGFGG FGSTSKNPKT GKHEYGIQVG ENKFTGIGDG IAQAKLNAEQ 250
    KAYHFLIQEE IKQQFQNLDY TNPASTLHEL FQKKVIMEVR YEFNEYHDEN 300
    GNPIWNCKAI LEGYGTFEAD NASKKQVKQD ASLKLLKFIA KTKIEQTEKW 350
    EIPTFYHGMA RIWHDEGKI 369
    Length:369
    Mass (Da):42,826
    Last modified:May 31, 2011 - v1
    Checksum:i6657D14A15ED1B13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002631 Genomic DNA. Translation: AEB13117.1.
    RefSeqiWP_013700428.1. NC_015385.1.
    YP_004364414.1. NC_015385.1.

    Genome annotation databases

    EnsemblBacteriaiAEB13117; AEB13117; Tresu_0151.
    GeneIDi10430238.
    KEGGitsu:Tresu_0151.
    PATRICi54426797. VBITreSuc166698_0157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002631 Genomic DNA. Translation: AEB13117.1 .
    RefSeqi WP_013700428.1. NC_015385.1.
    YP_004364414.1. NC_015385.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEB13117 ; AEB13117 ; Tresu_0151 .
    GeneIDi 10430238.
    KEGGi tsu:Tresu_0151.
    PATRICi 54426797. VBITreSuc166698_0157.

    Phylogenomic databases

    KOi K03685.

    Enzyme and pathway databases

    BioCyci TSUC869209:GHSS-155-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of chromosome of Treponema succinifaciens DSM 2489."
      Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.
      , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33096 / DSM 2489 / 6091.

    Entry informationi

    Entry nameiRNC_TRES6
    AccessioniPrimary (citable) accession number: F2NV13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3