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Protein

Xylose isomerase

Gene

xylA

Organism
Treponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001UniRule annotation
Active sitei103 – 1031UniRule annotation
Metal bindingi231 – 2311Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 2UniRule annotation
Metal bindingi270 – 2701Magnesium 2UniRule annotation
Metal bindingi295 – 2951Magnesium 1UniRule annotation
Metal bindingi306 – 3061Magnesium 2UniRule annotation
Metal bindingi308 – 3081Magnesium 2UniRule annotation
Metal bindingi338 – 3381Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTSUC869209:GHSS-1311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Tresu_1283Imported
OrganismiTreponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)Imported
Taxonomic identifieri869209 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000006852 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi869209.Tresu_1283.

Structurei

3D structure databases

ProteinModelPortaliF2NRV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2NRV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFKGSKEY FPGIGQIKYE GPESKNPLAF KYYDAEKVVM GKKMKDWLKF
60 70 80 90 100
TVAYWHSFCA DGGDPFGSGT REFTWKTPEE KVDAAFEFIT KLGCGYYAWH
110 120 130 140 150
DRDICPEGTS PADSEKKLSH ITDLLLERQK ETGVKLLWGT ANVFNNPRYM
160 170 180 190 200
NGAATNPDFD VVAQAASQIK AAIDNTIKLG GAGYTFWGGR EGYMSLLNTD
210 220 230 240 250
MKAEKEHLAM MLTLARDYAR KQGFTGCFYI EPKPMEPTKH QYDYDSETVI
260 270 280 290 300
GFLRAHGLDK DFKLNIEANH AELAGHEFAH ELTVCVDNGM LGSIDANRGD
310 320 330 340 350
PVNGWDTDQF PVSIYETTQA MLQVIRMGGF TTGGLNFDAK VRRNSVAPED
360 370 380 390 400
LFIAHIGGMD IFARGLEKAV QLIEDRRIPS MLKERYASFE TGNGKAFAEG
410 420 430
KLTLDQVASL AKPYEQVAKT SGKQELYENI LNQICLG
Length:437
Mass (Da):48,833
Last modified:May 31, 2011 - v1
Checksum:i8AC37EE4E50936AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002631 Genomic DNA. Translation: AEB14191.1.
RefSeqiWP_013701478.1. NC_015385.1.

Genome annotation databases

EnsemblBacteriaiAEB14191; AEB14191; Tresu_1283.
KEGGitsu:Tresu_1283.
PATRICi54429232. VBITreSuc166698_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002631 Genomic DNA. Translation: AEB14191.1.
RefSeqiWP_013701478.1. NC_015385.1.

3D structure databases

ProteinModelPortaliF2NRV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi869209.Tresu_1283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB14191; AEB14191; Tresu_1283.
KEGGitsu:Tresu_1283.
PATRICi54429232. VBITreSuc166698_1349.

Phylogenomic databases

KOiK01805.
OMAiHTFQHEL.

Enzyme and pathway databases

BioCyciTSUC869209:GHSS-1311-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of chromosome of Treponema succinifaciens DSM 2489."
    Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.
    , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33096 / DSM 2489 / 6091Imported.

Entry informationi

Entry nameiF2NRV5_TRES6
AccessioniPrimary (citable) accession number: F2NRV5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: July 22, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.