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Protein

Thymidine kinase

Gene

tdk

Organism
Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi150ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi90 – 93ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Marky_1398Imported
OrganismiMarinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)Imported
Taxonomic identifieri869210 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMarinithermus
Proteomesi
  • UP000007030 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi869210.Marky_1398.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2NMG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLPWYPGW LEAIVGPMFS GKSEELIRRV KRALIAGQRV QVFKPRLDDR
60 70 80 90 100
YHASDVVSHD GTRVEAVAVA DSRELRARLQ DPLPQVVAVD EVQFFDAGLV
110 120 130 140 150
ELVMELTEQG VRVIVAGLDL DFRGEPFGII PELLARAEWV EKLSAVCPRC
160 170 180 190 200
GRAATRTQRL INGQPARYDD PVILVGAHEV YEPRCRGCHT VVRENVPQQS

S
Length:201
Mass (Da):22,539
Last modified:May 31, 2011 - v1
Checksum:iC1A165A3292AE1B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002630 Genomic DNA. Translation: AEB12133.1.
RefSeqiWP_013704180.1. NC_015387.1.

Genome annotation databases

EnsemblBacteriaiAEB12133; AEB12133; Marky_1398.
KEGGimhd:Marky_1398.
PATRICi54435170. VBIMarHyd166763_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002630 Genomic DNA. Translation: AEB12133.1.
RefSeqiWP_013704180.1. NC_015387.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi869210.Marky_1398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB12133; AEB12133; Marky_1398.
KEGGimhd:Marky_1398.
PATRICi54435170. VBIMarHyd166763_1384.

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF2NMG3_MARHT
AccessioniPrimary (citable) accession number: F2NMG3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.