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F2NMG3

- F2NMG3_MARHT

UniProt

F2NMG3 - F2NMG3_MARHT

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Protein

Thymidine kinase

Gene
tdk, Marky_1398
Organism
Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911Proton acceptor By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi150 – 1501Zinc By similarityUniRule annotation
Metal bindingi185 – 1851Zinc By similarityUniRule annotation
Metal bindingi188 – 1881Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATP By similarityUniRule annotation
Nucleotide bindingi90 – 934ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMHYD869210:GHEE-1436-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Marky_1398Imported
OrganismiMarinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)Imported
Taxonomic identifieri869210 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMarinithermus
ProteomesiUP000007030: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2NMG3-1 [UniParc]FASTAAdd to Basket

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MPYLPWYPGW LEAIVGPMFS GKSEELIRRV KRALIAGQRV QVFKPRLDDR    50
YHASDVVSHD GTRVEAVAVA DSRELRARLQ DPLPQVVAVD EVQFFDAGLV 100
ELVMELTEQG VRVIVAGLDL DFRGEPFGII PELLARAEWV EKLSAVCPRC 150
GRAATRTQRL INGQPARYDD PVILVGAHEV YEPRCRGCHT VVRENVPQQS 200
S 201
Length:201
Mass (Da):22,539
Last modified:May 31, 2011 - v1
Checksum:iC1A165A3292AE1B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002630 Genomic DNA. Translation: AEB12133.1.
RefSeqiWP_013704180.1. NC_015387.1.
YP_004368243.1. NC_015387.1.

Genome annotation databases

EnsemblBacteriaiAEB12133; AEB12133; Marky_1398.
GeneIDi10434306.
KEGGimhd:Marky_1398.
PATRICi54435170. VBIMarHyd166763_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002630 Genomic DNA. Translation: AEB12133.1 .
RefSeqi WP_013704180.1. NC_015387.1.
YP_004368243.1. NC_015387.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB12133 ; AEB12133 ; Marky_1398 .
GeneIDi 10434306.
KEGGi mhd:Marky_1398.
PATRICi 54435170. VBIMarHyd166763_1384.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci MHYD869210:GHEE-1436-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14884 / JCM 11576 / T1.

Entry informationi

Entry nameiF2NMG3_MARHT
AccessioniPrimary (citable) accession number: F2NMG3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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