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Protein

Thymidine kinase

Gene

tdk

Organism
Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi150ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi90 – 93ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMHYD869210:G1GSR-1416-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Marky_1398Imported
OrganismiMarinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)Imported
Taxonomic identifieri869210 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMarinithermus
Proteomesi
  • UP000007030 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi869210.Marky_1398

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

F2NMG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLPWYPGW LEAIVGPMFS GKSEELIRRV KRALIAGQRV QVFKPRLDDR
60 70 80 90 100
YHASDVVSHD GTRVEAVAVA DSRELRARLQ DPLPQVVAVD EVQFFDAGLV
110 120 130 140 150
ELVMELTEQG VRVIVAGLDL DFRGEPFGII PELLARAEWV EKLSAVCPRC
160 170 180 190 200
GRAATRTQRL INGQPARYDD PVILVGAHEV YEPRCRGCHT VVRENVPQQS

S
Length:201
Mass (Da):22,539
Last modified:May 31, 2011 - v1
Checksum:iC1A165A3292AE1B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002630 Genomic DNA Translation: AEB12133.1
RefSeqiWP_013704180.1, NC_015387.1

Genome annotation databases

EnsemblBacteriaiAEB12133; AEB12133; Marky_1398
KEGGimhd:Marky_1398

Similar proteinsi

Entry informationi

Entry nameiF2NMG3_MARHT
AccessioniPrimary (citable) accession number: F2NMG3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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