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F2NFY1 (F2NFY1_DESAR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Desac_0508 EMBL AEB08394.1
OrganismDesulfobacca acetoxidans (strain ATCC 700848 / DSM 11109 / ASRB2) [Complete proteome] [HAMAP] EMBL AEB08394.1
Taxonomic identifier880072 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeDesulfobacca

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 304202ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding131 – 18656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2591Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2731Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F2NFY1 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 9FB34DB6FBE63E02

FASTA30933,605
        10         20         30         40         50         60 
MRKLRLALLS GGKSSEREVS LKSGGQVFEA LDKAKYDIYR YDPQTDLRQL INDAPNLDVA 

        70         80         90        100        110        120 
LIIMHGRWGE DGTIQGLLDL LGLPYQGSGV MASALAMNKE LSKTLYRQAG LKVPRAVFFS 

       130        140        150        160        170        180 
RQDAIDPRAL EAAVGLPAVI KPVNEGSSIG VTVARHLDQL GAGIGEALAY DRRVLVEEFI 

       190        200        210        220        230        240 
SGMEVTAGVL GNDALLPLPL VEIVPDKSHP FFNYEAKYLP GATEEIVPAR LSPEMTIRVQ 

       250        260        270        280        290        300 
ECGLTAHRAL GCWGYSRTDT IVRDGEIYVL ETNTIPGMTA TSLFPQAARA MGLDFPALLD 


RLVELALEK 

« Hide

References

[1]"The complete genome of Desulfobacca acetoxidans DSM 11109."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F. expand/collapse author list , Hugenholtz P., Woyke T., Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700848 / DSM 11109 / ASRB2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002629 Genomic DNA. Translation: AEB08394.1.
RefSeqYP_004369575.1. NC_015388.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEB08394; AEB08394; Desac_0508.
GeneID10435697.
KEGGdao:Desac_0508.
PATRIC54438080. VBIDesAce170587_0557.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKYTEGFA.

Enzyme and pathway databases

BioCycDACE880072:GHK9-515-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2NFY1_DESAR
AccessionPrimary (citable) accession number: F2NFY1
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)