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F2N9E1

- F2N9E1_CORGP

UniProt

F2N9E1 - F2N9E1_CORGP

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Coriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi265 – 2651Magnesium or manganese 1UniRule annotation
Metal bindingi277 – 2771Magnesium or manganese 1UniRule annotation
Metal bindingi277 – 2771Magnesium or manganese 2UniRule annotation
Metal bindingi279 – 2791Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 19256ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCGLO700015:GH6A-1848-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Corgl_1794Imported
OrganismiCoriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2)Imported
Taxonomic identifieri700015 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeCoriobacterium
ProteomesiUP000006851: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 310202ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiEDPARES.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2N9E1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPISRRESMS IAVLAGGTSP EREISFASGE SVCRALKQAG YGRVETLDPA
60 70 80 90 100
DSGFLKEIES ASFDAVFIAL HGAGGEDGTI QGVLDYLHIP YTGSGVRASA
110 120 130 140 150
CAADKDVSKI IFEHAGIPVA RGVTLCRGDE LNPDSLVAEL GKECFVKPAM
160 170 180 190 200
NGSSLGVSLI RHPSELPKAV ERAFESSDKV LIEQRLIGTE ISVGVLGGRD
210 220 230 240 250
AKALPVVEIM GQEGTDFYNK EVKYIDPALV HRIPARLPTG ICETAGALAL
260 270 280 290 300
GAHRALGCYG FSRSDFIVTE EGPVILETNT IPGMTEASLF PDEIRHCGRT
310
FAEACDEMIM LALQRVRA
Length:318
Mass (Da):33,851
Last modified:May 31, 2011 - v1
Checksum:iCE1BC9F727FBA87D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002628 Genomic DNA. Translation: AEB07889.1.
RefSeqiWP_013709631.1. NC_015389.1.
YP_004373704.1. NC_015389.1.

Genome annotation databases

EnsemblBacteriaiAEB07889; AEB07889; Corgl_1794.
GeneIDi10440054.
KEGGicgo:Corgl_1794.
PATRICi54447375. VBICorGlo157054_1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002628 Genomic DNA. Translation: AEB07889.1 .
RefSeqi WP_013709631.1. NC_015389.1.
YP_004373704.1. NC_015389.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB07889 ; AEB07889 ; Corgl_1794 .
GeneIDi 10440054.
KEGGi cgo:Corgl_1794.
PATRICi 54447375. VBICorGlo157054_1927.

Phylogenomic databases

KOi K01921.
OMAi EDPARES.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CGLO700015:GH6A-1848-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 49209 / DSM 20642 / JCM 10262 / PW2Imported.

Entry informationi

Entry nameiF2N9E1_CORGP
AccessioniPrimary (citable) accession number: F2N9E1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3