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Protein

D-alanine--D-alanine ligase

Gene

Corgl_1497

Organism
Coriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCGLO700015:GH6A-1546-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Corgl_1497Imported
OrganismiCoriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2)Imported
Taxonomic identifieri700015 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeCoriobacterium
ProteomesiUP000006851 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiMGGASFE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2N8Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVIMGGT SLEREFSLKS GHRIARELEA KDHIVLPLDA TSELTCALRS
60 70 80 90 100
GRPDVALIAV HGLGGEDGAI QGLLEFLRIP YVGSTSESCR ASWNKVDLPR
110 120 130 140 150
AFNSYLLAHP DRLEDASASR SAHERGCSSE HPADQLDAVF SRVGSDCARD
160 170 180 190 200
MLPNNPLIPT PKTFCLTEVA FRSMGAAAAL DLVCDRLGYP VAVKPACGGS
210 220 230 240 250
AMGVSRVGCQ EALGEAIMGA LSFDDKVIIQ EWLEGVELSV AICCGQDGAA
260 270 280 290 300
RSLTPVEIAP KETFFTTAAR LDPSAVDYFA PVREESLVAN GHGRSADDLD
310 320 330 340 350
SLIARTALDA FCALGCRDLA RVDMMLSDGV AYVIDVKVAP GMSENSLLPM
360 370
AVAASGFDLG DIFDGLVRRA AVRGA
Length:375
Mass (Da):39,656
Last modified:May 30, 2011 - v1
Checksum:iBFCE5C0DE04E78AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002628 Genomic DNA. Translation: AEB07596.1.
RefSeqiYP_004373411.1. NC_015389.1.

Genome annotation databases

EnsemblBacteriaiAEB07596; AEB07596; Corgl_1497.
KEGGicgo:Corgl_1497.
PATRICi54446737. VBICorGlo157054_1615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002628 Genomic DNA. Translation: AEB07596.1.
RefSeqiYP_004373411.1. NC_015389.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB07596; AEB07596; Corgl_1497.
KEGGicgo:Corgl_1497.
PATRICi54446737. VBICorGlo157054_1615.

Phylogenomic databases

KOiK01921.
OMAiMGGASFE.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciCGLO700015:GH6A-1546-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 49209 / DSM 20642 / JCM 10262 / PW2Imported.

Entry informationi

Entry nameiF2N8Z6_CORGP
AccessioniPrimary (citable) accession number: F2N8Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2011
Last sequence update: May 30, 2011
Last modified: March 31, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.