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F2MK92

- F2MK92_LACCD

UniProt

F2MK92 - F2MK92_LACCD

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Protein

Thymidine kinase

Gene

kitH

Organism
Lactobacillus casei (strain BD-II)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLCAS998820:GLF4-1404-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:kitHImported
Synonyms:tdkUniRule annotation
Ordered Locus Names:LCBD_1353Imported
OrganismiLactobacillus casei (strain BD-II)Imported
Taxonomic identifieri998820 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006850: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF2MK92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2MK92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLFFRYGA MNSGKSIEIL KVAHNYEEQN KRVILMTSAV DDRAGVGMIA
60 70 80 90 100
SRIGLERTAI PITHETNLYD IIKATDPKAA CVLIDEAQFL QKHHIFEAAR
110 120 130 140 150
VVDELHIPVM AFGLKNDFRN ELFEGSKYLL LYADKIEEMK TICWFCAKKA
160 170 180 190
IMNLRIHDGQ PVYEGKQVLI GGNESYYPVC RHHYFHPPLK QIDPTD
Length:196
Mass (Da):22,427
Last modified:May 31, 2011 - v1
Checksum:i2AA4E69E19ACC6F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002618 Genomic DNA. Translation: AEA56850.1.
RefSeqiYP_005859391.1. NC_017474.1.

Genome annotation databases

EnsemblBacteriaiAEA56850; AEA56850; LCBD_1353.
GeneIDi12467702.
KEGGilcs:LCBD_1353.
PATRICi54293407. VBILacCas184581_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002618 Genomic DNA. Translation: AEA56850.1 .
RefSeqi YP_005859391.1. NC_017474.1.

3D structure databases

ProteinModelPortali F2MK92.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA56850 ; AEA56850 ; LCBD_1353 .
GeneIDi 12467702.
KEGGi lcs:LCBD_1353.
PATRICi 54293407. VBILacCas184581_1332.

Phylogenomic databases

KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci LCAS998820:GLF4-1404-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the probiotic strain Lactobacillus casei BD-II."
    Ai L., Chen C., Zhou F., Wang L., Zhang H., Chen W., Guo B.
    J. Bacteriol. 193:3160-3161(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BD-IIImported.

Entry informationi

Entry nameiF2MK92_LACCD
AccessioniPrimary (citable) accession number: F2MK92
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3