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F2LYS5

- F2LYS5_LACAL

UniProt

F2LYS5 - F2LYS5_LACAL

Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus amylovorus (strain GRL 1118)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi154 – 1541ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation
    Metal bindingi191 – 1911ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi93 – 964ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLAMY695562:GLF1-794-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:LAB52_03790Imported
    OrganismiLactobacillus amylovorus (strain GRL 1118)Imported
    Taxonomic identifieri695562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000008140: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2LYS5-1 [UniParc]FASTAAdd to Basket

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    MAQLFFRYGA MSSGKTIEIL KVAHNYEAQG RRIALMTSGL DNRSGVGTVA    50
    SRIGLHRKAI PITSEMNLFE YIKKMNDHDL ADGDGKLACV LIDEAQFLKR 100
    HHVLECAKIV DDFNIPVMTF GLKNDFQNHL FEGSENLLIF ADKIEEMKTI 150
    CHYCGHKATM NLRVNNGKPV YEGEQVQIGG DESYYPVCRY HYFHPGSKR 199
    Length:199
    Mass (Da):22,576
    Last modified:May 31, 2011 - v1
    Checksum:i9FB40612A8C96756
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002609 Genomic DNA. Translation: AEA31728.1.
    RefSeqiYP_005853733.1. NC_017470.1.

    Genome annotation databases

    EnsemblBacteriaiAEA31728; AEA31728; LAB52_03790.
    GeneIDi12461889.
    KEGGilay:LAB52_03790.
    PATRICi54149825. VBILacAmy156066_0748.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002609 Genomic DNA. Translation: AEA31728.1 .
    RefSeqi YP_005853733.1. NC_017470.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA31728 ; AEA31728 ; LAB52_03790 .
    GeneIDi 12461889.
    KEGGi lay:LAB52_03790.
    PATRICi 54149825. VBILacAmy156066_0748.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci LAMY695562:GLF1-794-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Lactobacillus amylovorus GRL1118, isolated from pig ileum."
      Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
      J. Bacteriol. 193:3147-3148(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GRL 1118Imported.
    2. Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
      Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GRL 1118.

    Entry informationi

    Entry nameiF2LYS5_LACAL
    AccessioniPrimary (citable) accession number: F2LYS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3