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F2LYS5

- F2LYS5_LACAL

UniProt

F2LYS5 - F2LYS5_LACAL

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Protein

Thymidine kinase

Gene
tdk, LAB52_03790
Organism
Lactobacillus amylovorus (strain GRL 1118)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptor By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi154 – 1541Zinc By similarityUniRule annotation
Metal bindingi188 – 1881Zinc By similarityUniRule annotation
Metal bindingi191 – 1911Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi93 – 964ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLAMY695562:GLF1-794-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:LAB52_03790Imported
OrganismiLactobacillus amylovorus (strain GRL 1118)Imported
Taxonomic identifieri695562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000008140: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2LYS5-1 [UniParc]FASTAAdd to Basket

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MAQLFFRYGA MSSGKTIEIL KVAHNYEAQG RRIALMTSGL DNRSGVGTVA    50
SRIGLHRKAI PITSEMNLFE YIKKMNDHDL ADGDGKLACV LIDEAQFLKR 100
HHVLECAKIV DDFNIPVMTF GLKNDFQNHL FEGSENLLIF ADKIEEMKTI 150
CHYCGHKATM NLRVNNGKPV YEGEQVQIGG DESYYPVCRY HYFHPGSKR 199
Length:199
Mass (Da):22,576
Last modified:May 31, 2011 - v1
Checksum:i9FB40612A8C96756
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002609 Genomic DNA. Translation: AEA31728.1.
RefSeqiYP_005853733.1. NC_017470.1.

Genome annotation databases

EnsemblBacteriaiAEA31728; AEA31728; LAB52_03790.
GeneIDi12461889.
KEGGilay:LAB52_03790.
PATRICi54149825. VBILacAmy156066_0748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002609 Genomic DNA. Translation: AEA31728.1 .
RefSeqi YP_005853733.1. NC_017470.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA31728 ; AEA31728 ; LAB52_03790 .
GeneIDi 12461889.
KEGGi lay:LAB52_03790.
PATRICi 54149825. VBILacAmy156066_0748.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci LAMY695562:GLF1-794-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Lactobacillus amylovorus GRL1118, isolated from pig ileum."
    Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
    J. Bacteriol. 193:3147-3148(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GRL 1118.
  2. Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GRL 1118.

Entry informationi

Entry nameiF2LYS5_LACAL
AccessioniPrimary (citable) accession number: F2LYS5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi