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F2LY00 (F2LY00_HIPMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP-Rule MF_00412
Short name=GPR HAMAP-Rule MF_00412
EC=1.2.1.41 HAMAP-Rule MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Gene names
Name:proA HAMAP-Rule MF_00412
Ordered Locus Names:Hipma_0288
OrganismHippea maritima (strain ATCC 700847 / DSM 10411 / MH2) [Complete proteome] [HAMAP] EMBL AEA33265.1
Taxonomic identifier760142 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfurellales › Desulfurellaceae › Hippea ›

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP-Rule MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP-Rule MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP-Rule MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP-Rule MF_00412

Sequences

Sequence LengthMass (Da)Tools
F2LY00 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 1E073516CBDF1909

FASTA41846,514
        10         20         30         40         50         60 
MSLKERIEQL AHNTKTASQS LAKLTEDRIN AALEKLAELI DKNRHKIKEI NEIDIKNAKK 

        70         80         90        100        110        120 
INLKASLIDR LLLNDKRIDG MIEAVETVIK LKSPVGKVID GWRLENGLNI ERVKVPIGCL 

       130        140        150        160        170        180 
GIIYESRPNV TVDASILCLK SSNGAILKGG KEAINSNRLL VGLIKEALSS HNINENVVNF 

       190        200        210        220        230        240 
IDETDRDAVL YMLKLDKYID AIVPRGGEGL IRFVSENATM PVIKHDKGLC HGYVDESADL 

       250        260        270        280        290        300 
EKALSITYNA KVQRPGVCNA LETLLVHKNI AQEFLVKFKE LMDSAGVELR GCSETLKILP 

       310        320        330        340        350        360 
DIKLAEEDDW HTEYLDLILS IKIVDSIDEA IEHINRYGSH HSETIITENH TNAERFLDEV 

       370        380        390        400        410 
DAACVYVNAS TRFTDGGVFG FGAEIGISTN KLHARGPVGL DELTTYKYKI RGNGQIRE

« Hide

References

[1]"The complete genome of Hippea maritima DSM 10411."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Lu M., Detter J.C., Tapia R., Han C., Land M., Hauser L. expand/collapse author list , Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700847 / DSM 10411 / MH2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002606 Genomic DNA. Translation: AEA33265.1.
RefSeqYP_004339324.1. NC_015318.1.

3D structure databases

ProteinModelPortalF2LY00.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA33265; AEA33265; Hipma_0288.
GeneID10391609.
KEGGhmr:Hipma_0288.
PATRIC54411223. VBIHipMar155866_0292.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00147.

Enzyme and pathway databases

BioCycHMAR760142:GHVE-300-MONOMER.
UniPathwayUPA00098; UER00360.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPMF_00412. ProA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PANTHERPTHR11063:SF1. PTHR11063:SF1. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. proA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2LY00_HIPMA
AccessionPrimary (citable) accession number: F2LY00
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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