ID F2LD61_BURGS Unreviewed; 892 AA. AC F2LD61; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 27-MAR-2024, entry version 67. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=bgla_1g12430 {ECO:0000313|EMBL:AEA59920.1}; OS Burkholderia gladioli (strain BSR3). OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia. OX NCBI_TaxID=999541 {ECO:0000313|EMBL:AEA59920.1, ECO:0000313|Proteomes:UP000008316}; RN [1] {ECO:0000313|EMBL:AEA59920.1, ECO:0000313|Proteomes:UP000008316} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BSR3 {ECO:0000313|EMBL:AEA59920.1, RC ECO:0000313|Proteomes:UP000008316}; RX PubMed=21478339; DOI=10.1128/JB.00420-11; RA Seo Y.S., Lim J., Choi B.S., Kim H., Goo E., Lee B., Lim J.S., Choi I.Y., RA Moon J.S., Kim J., Hwang I.; RT "Complete genome sequence of Burkholderia gladioli BSR3."; RL J. Bacteriol. 193:3149-3149(2011). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002599; AEA59920.1; -; Genomic_DNA. DR RefSeq; WP_013697269.1; NC_015381.1. DR AlphaFoldDB; F2LD61; -. DR STRING; 999541.bgla_1g12430; -. DR KEGG; bgd:bgla_1g12430; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_4; -. DR Proteomes; UP000008316; Chromosome 1. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 338..430 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 171..239 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 559..596 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 196..235 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 572..588 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 892 AA; 97663 MW; 14BA82267CFDD3D1 CRC64; MASKLAEYQR KRRFDASPEP AGKRGAQARP RHDPERELHF VVQEHHARRL HYDFRLELDG VLKSWAVPKG PSTEPAEKRL AVHVEDHPLD YAGFEGEIPP GHYGAGSVRI DDQGVWRPDG GIAGARRGYR EGKLSFELDG HRLHGRWSLV RTHLPERNGK SSWLLIKARD EQAGPPGGER IKAARKQPAT AAAKRAGERA ETHGDKHAEK HVEKQAEKRG APPPRGKRAA DRAGRREALP ATLAPQLATL VAAPPEGEDW RYEMKFDGYR VLIRIAGRGR RRSVQVFTRE GKDWSAKFRR QCAALADLPV NNAWLDAEAV VLDARGLPDF GALQQALSAG EDAAIVFFVF DLPFLDGRAL ADLPLDTRRE RLAACFGGAG RQAVQLSPTL KGEPAELLAA ASRAGLEGLI GKRADSPYRA GRSASWIKLK CRQRQEFVIG GFSEPRGSRS GFGALLLGVH ERPAQGRRRA GGLAYVGRVG TGFDRRALDA IAARLRKIER GDAPFAVPPA ERGDAVHWVE PRLVAECEFA GWTADGLVRQ AAFIGLREDK PAGQIVRETA APAGGQPTGG RMRTDHQATG SRSRGKAANH ATGRNDDATV AGVRVTHPER VVDTESGLRK IDVVRYYAAI AEHLLPQLAG RPVSLVRYMK GIDGPSFFQK HAGPRGMGFV TRHPGLDPGH DALITLDDRE ALVGAAQFDA LEFHTWNACV DRIERPDRLV FDLDPDPALP WRAMIEAAQA LRALLDALGL PCFCKTSGGK GLHLVVPITR HASWDQARDF SQAVAQHLAG VAPERFSAKM GAQNRKGRIF VDYLRNGRGA STVAAWSARA RPGMGVSVPI DWDELPGTRG GAQWTIAEVP QRLASLRRDP WDGYEAARRR LTAAMRERLG KL //