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Protein

Indolepyruvate oxidoreductase subunit IorA

Gene

TUZN_0362

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.UniRule annotation

Catalytic activityi

(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi532Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi535Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi538Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi544Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi562Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi565Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi568Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi572Iron-sulfur 1 (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, PyruvateImported

Enzyme and pathway databases

BioCyciTUZO999630:G1GSD-358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Indolepyruvate oxidoreductase subunit IorAUniRule annotation (EC:1.2.7.8UniRule annotation)
Short name:
IORUniRule annotation
Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit alphaUniRule annotation
Gene namesi
Ordered Locus Names:TUZN_0362Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
Proteomesi
  • UP000008138 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of the IorA and IorB subunits.UniRule annotation

Protein-protein interaction databases

STRINGi999630.TUZN_0362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini523 – 5524Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini553 – 5824Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Phylogenomic databases

eggNOGiarCOG01609. Archaea.
COG4231. LUCA.
KOiK00179.
OMAiTFLHTGI.

Family and domain databases

InterProiView protein in InterPro
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017721. Indolepyruvate_Fd_OxRdtase_asu.
IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR029061. THDP-binding.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/PFOR_II.
PfamiView protein in Pfam
PF00037. Fer4. 1 hit.
PF01855. POR_N. 1 hit.
PF02775. TPP_enzyme_C. 1 hit.
PIRSFiPIRSF006439. Indolepyruvate_ferr_oxidored. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
PROSITEiView protein in PROSITE
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

F2L2S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLLGNEA IAYGALSAGV AVAAGYPGTP SSEIIETLLE YRDRFVQWAS
60 70 80 90 100
NEKTAVEIAY GAALAGARAL AAMKHVGLNV AADPLHSAAY TGVVGGFLIV
110 120 130 140 150
TADDPNMWSS QNEQDTRWYG LQSYIPVLEP SDPQEAFKMA KEGLMLSEAL
160 170 180 190 200
EHPVILRSVT RVSHVRAPVV VEPPAPPKFG KFARNVERYV LVPQNARRRK
210 220 230 240 250
AEVLRRWDSF ADLSSRFLSI EGDGEVVVVA SGVGYLYAVE ALERLRVKAA
260 270 280 290 300
VVKVGMPVPL PKKLADVGAG EVVVVEEGDP VVEMQLRAMG VKTRGKIDGF
310 320 330 340 350
FPKIGELTLR SVVEGISKAL GLGVRLPDPP TPPLQPPPRP PYLCPGCPHM
360 370 380 390 400
GTFYAFKIAS AGQKVIWSGD IGCYTLGINT GQQDLATHMG SSLGLGMGIA
410 420 430 440 450
VADREKLVVA TVGDSTFYHA ALPQLIDLKT KKVPLVLVVM DNEYTAMTGG
460 470 480 490 500
QPSPSRSVPA ERLAEAVGVK HYVIDPADLK RSVEIAKAAV ADAKSGEPVV
510 520 530 540 550
VVSRRPCTLE ALRHARRSGF KPPKFYVVAD KCRSCGICYN VLKCYAIAKL
560 570 580 590
PDGKAWIDPS LCSGCSMCAQ VCPYDAIKPT EPEKVGKWLE LWSQA
Length:595
Mass (Da):64,017
Last modified:May 31, 2011 - v1
Checksum:iE2DF0AEF25454B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA. Translation: AEA11859.1.
RefSeqiWP_013679195.1. NC_015315.1.

Genome annotation databases

EnsemblBacteriaiAEA11859; AEA11859; TUZN_0362.
GeneIDi10359908.
KEGGituz:TUZN_0362.

Similar proteinsi

Entry informationi

Entry nameiF2L2S1_THEU7
AccessioniPrimary (citable) accession number: F2L2S1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported