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F2L2N0

- F2L2N0_THEU7

UniProt

F2L2N0 - F2L2N0_THEU7

Protein

DNA ligase

Gene

lig

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei253 – 2531ATPUniRule annotation
    Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei275 – 2751ATPUniRule annotation
    Binding sitei305 – 3051ATPUniRule annotation
    Binding sitei345 – 3451ATPUniRule annotation
    Binding sitei420 – 4201ATPUniRule annotation
    Binding sitei426 – 4261ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTUZO999630:GJC9-1593-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:TUZN_1611Imported
    OrganismiThermoproteus uzoniensis (strain 768-20)Imported
    Taxonomic identifieri999630 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
    ProteomesiUP000008138: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF2L2N0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2L2N0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR    50
    PPWEGLELGV GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR 100
    RQAQTLLAFA GGRKAGLSIS QVYDTLFKVA KASGEGSQDL KISLLSSLFS 150
    QLSPDEAKYV ARFVVGRLRL GVADMTVIDA LAEAFGVPEE ALERAYNVRP 200
    DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR EILAKLGGAA 250
    ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA 300
    VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL 350
    DGEDLTDKPL MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS 400
    MGMEGLVCKS PTSVYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR 450
    GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS GFTDADLKKM YQMLEPYKID 500
    HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG AVRPDVGLAI 550
    RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP 594
    Length:594
    Mass (Da):65,973
    Last modified:May 31, 2011 - v1
    Checksum:i853AA43A566CE3AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002590 Genomic DNA. Translation: AEA13078.1.
    RefSeqiWP_013680413.1. NC_015315.1.
    YP_004338390.1. NC_015315.1.

    Genome annotation databases

    EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611.
    GeneIDi10361131.
    KEGGituz:TUZN_1611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002590 Genomic DNA. Translation: AEA13078.1 .
    RefSeqi WP_013680413.1. NC_015315.1.
    YP_004338390.1. NC_015315.1.

    3D structure databases

    ProteinModelPortali F2L2N0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA13078 ; AEA13078 ; TUZN_1611 .
    GeneIDi 10361131.
    KEGGi tuz:TUZN_1611.

    Phylogenomic databases

    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci TUZO999630:GJC9-1593-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
      Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
      J. Bacteriol. 193:3156-3157(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 768-20Imported.
    2. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
      Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
      Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 768-20.

    Entry informationi

    Entry nameiF2L2N0_THEU7
    AccessioniPrimary (citable) accession number: F2L2N0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3