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Protein

DNA ligase

Gene

lig

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATPUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei275 – 2751ATPUniRule annotation
Binding sitei305 – 3051ATPUniRule annotation
Binding sitei345 – 3451ATPUniRule annotation
Binding sitei420 – 4201ATPUniRule annotation
Binding sitei426 – 4261ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTUZO999630:GJC9-1593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TUZN_1611Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000008138 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi999630.TUZN_1611.

Structurei

3D structure databases

ProteinModelPortaliF2L2N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiLACYDEQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2L2N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR
60 70 80 90 100
PPWEGLELGV GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR
110 120 130 140 150
RQAQTLLAFA GGRKAGLSIS QVYDTLFKVA KASGEGSQDL KISLLSSLFS
160 170 180 190 200
QLSPDEAKYV ARFVVGRLRL GVADMTVIDA LAEAFGVPEE ALERAYNVRP
210 220 230 240 250
DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR EILAKLGGAA
260 270 280 290 300
ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA
310 320 330 340 350
VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL
360 370 380 390 400
DGEDLTDKPL MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS
410 420 430 440 450
MGMEGLVCKS PTSVYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR
460 470 480 490 500
GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS GFTDADLKKM YQMLEPYKID
510 520 530 540 550
HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG AVRPDVGLAI
560 570 580 590
RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP
Length:594
Mass (Da):65,973
Last modified:May 31, 2011 - v1
Checksum:i853AA43A566CE3AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1.
RefSeqiWP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

Genome annotation databases

EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611.
GeneIDi10361131.
KEGGituz:TUZN_1611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1.
RefSeqiWP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

3D structure databases

ProteinModelPortaliF2L2N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi999630.TUZN_1611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611.
GeneIDi10361131.
KEGGituz:TUZN_1611.

Phylogenomic databases

KOiK10747.
OMAiLACYDEQ.

Enzyme and pathway databases

BioCyciTUZO999630:GJC9-1593-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 193:3156-3157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 768-20Imported.
  2. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 768-20.

Entry informationi

Entry nameiF2L2N0_THEU7
AccessioniPrimary (citable) accession number: F2L2N0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 24, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.