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F2L2N0

- F2L2N0_THEU7

UniProt

F2L2N0 - F2L2N0_THEU7

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Protein

DNA ligase

Gene

lig

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATPUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei275 – 2751ATPUniRule annotation
Binding sitei305 – 3051ATPUniRule annotation
Binding sitei345 – 3451ATPUniRule annotation
Binding sitei420 – 4201ATPUniRule annotation
Binding sitei426 – 4261ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTUZO999630:GJC9-1593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TUZN_1611Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000008138: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF2L2N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2L2N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR
60 70 80 90 100
PPWEGLELGV GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR
110 120 130 140 150
RQAQTLLAFA GGRKAGLSIS QVYDTLFKVA KASGEGSQDL KISLLSSLFS
160 170 180 190 200
QLSPDEAKYV ARFVVGRLRL GVADMTVIDA LAEAFGVPEE ALERAYNVRP
210 220 230 240 250
DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR EILAKLGGAA
260 270 280 290 300
ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA
310 320 330 340 350
VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL
360 370 380 390 400
DGEDLTDKPL MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS
410 420 430 440 450
MGMEGLVCKS PTSVYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR
460 470 480 490 500
GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS GFTDADLKKM YQMLEPYKID
510 520 530 540 550
HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG AVRPDVGLAI
560 570 580 590
RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP
Length:594
Mass (Da):65,973
Last modified:May 31, 2011 - v1
Checksum:i853AA43A566CE3AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1.
RefSeqiWP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

Genome annotation databases

EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611.
GeneIDi10361131.
KEGGituz:TUZN_1611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1 .
RefSeqi WP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

3D structure databases

ProteinModelPortali F2L2N0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA13078 ; AEA13078 ; TUZN_1611 .
GeneIDi 10361131.
KEGGi tuz:TUZN_1611.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci TUZO999630:GJC9-1593-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 193:3156-3157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 768-20Imported.
  2. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 768-20.

Entry informationi

Entry nameiF2L2N0_THEU7
AccessioniPrimary (citable) accession number: F2L2N0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3