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F2L2N0

- F2L2N0_THEU7

UniProt

F2L2N0 - F2L2N0_THEU7

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Protein

DNA ligase

Gene
lig, TUZN_1611
Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATP By similarityUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei275 – 2751ATP By similarityUniRule annotation
Binding sitei305 – 3051ATP By similarityUniRule annotation
Binding sitei345 – 3451ATP By similarityUniRule annotation
Binding sitei420 – 4201ATP By similarityUniRule annotation
Binding sitei426 – 4261ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTUZO999630:GJC9-1593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TUZN_1611Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000008138: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF2L2N0.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2L2N0-1 [UniParc]FASTAAdd to Basket

« Hide

MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR    50
PPWEGLELGV GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR 100
RQAQTLLAFA GGRKAGLSIS QVYDTLFKVA KASGEGSQDL KISLLSSLFS 150
QLSPDEAKYV ARFVVGRLRL GVADMTVIDA LAEAFGVPEE ALERAYNVRP 200
DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR EILAKLGGAA 250
ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA 300
VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL 350
DGEDLTDKPL MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS 400
MGMEGLVCKS PTSVYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR 450
GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS GFTDADLKKM YQMLEPYKID 500
HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG AVRPDVGLAI 550
RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP 594
Length:594
Mass (Da):65,973
Last modified:May 31, 2011 - v1
Checksum:i853AA43A566CE3AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1.
RefSeqiWP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

Genome annotation databases

EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611.
GeneIDi10361131.
KEGGituz:TUZN_1611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002590 Genomic DNA. Translation: AEA13078.1 .
RefSeqi WP_013680413.1. NC_015315.1.
YP_004338390.1. NC_015315.1.

3D structure databases

ProteinModelPortali F2L2N0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA13078 ; AEA13078 ; TUZN_1611 .
GeneIDi 10361131.
KEGGi tuz:TUZN_1611.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci TUZO999630:GJC9-1593-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 193:3156-3157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 768-20Imported.
  2. "Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
    Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 768-20.

Entry informationi

Entry nameiF2L2N0_THEU7
AccessioniPrimary (citable) accession number: F2L2N0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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