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F2L2N0 (F2L2N0_THEU7) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:TUZN_1611 EMBL AEA13078.1
OrganismThermoproteus uzoniensis (strain 768-20) [Complete proteome] [HAMAP] EMBL AEA13078.1
Taxonomic identifier999630 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2551N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2531ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site2751ATP By similarity HAMAP-Rule MF_00407
Binding site3051ATP By similarity HAMAP-Rule MF_00407
Binding site3451ATP By similarity HAMAP-Rule MF_00407
Binding site4201ATP By similarity HAMAP-Rule MF_00407
Binding site4261ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F2L2N0 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 853AA43A566CE3AD

FASTA59465,973
        10         20         30         40         50         60 
MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR PPWEGLELGV 

        70         80         90        100        110        120 
GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR RQAQTLLAFA GGRKAGLSIS 

       130        140        150        160        170        180 
QVYDTLFKVA KASGEGSQDL KISLLSSLFS QLSPDEAKYV ARFVVGRLRL GVADMTVIDA 

       190        200        210        220        230        240 
LAEAFGVPEE ALERAYNVRP DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR 

       250        260        270        280        290        300 
EILAKLGGAA ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA 

       310        320        330        340        350        360 
VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL DGEDLTDKPL 

       370        380        390        400        410        420 
MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS MGMEGLVCKS PTSVYEMGAR 

       430        440        450        460        470        480 
GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS 

       490        500        510        520        530        540 
GFTDADLKKM YQMLEPYKID HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG 

       550        560        570        580        590 
AVRPDVGLAI RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
J. Bacteriol. 193:3156-3157(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 768-20 EMBL AEA13078.1.
[2]"Complete genome sequence of the thermoacidophilic crenarchaeon Thermoproteus uzoniensis 768-20."
Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 768-20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002590 Genomic DNA. Translation: AEA13078.1.
RefSeqYP_004338390.1. NC_015315.1.

3D structure databases

ProteinModelPortalF2L2N0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA13078; AEA13078; TUZN_1611.
GeneID10361131.
KEGGtuz:TUZN_1611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMACTDIGEL.

Enzyme and pathway databases

BioCycTUZO999630:GJC9-1593-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2L2N0_THEU7
AccessionPrimary (citable) accession number: F2L2N0
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)