Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

lig

Organism
Thermoproteus uzoniensis (strain 768-20)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1
Active sitei255N6-AMP-lysine intermediateUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei275ATPUniRule annotation1
Binding sitei305ATPUniRule annotation1
Binding sitei345ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1
Binding sitei426ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTUZO999630:G1GSD-1596-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TUZN_1611Imported
OrganismiThermoproteus uzoniensis (strain 768-20)Imported
Taxonomic identifieri999630 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
Proteomesi
  • UP000008138 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi999630.TUZN_1611

Structurei

3D structure databases

ProteinModelPortaliF2L2N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 466DNA_LIGASE_A3InterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F2L2N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSELAKVL ASIESTTQRT TMVRLLVGLF KKLEPAEIDK AIYIILGDLR
60 70 80 90 100
PPWEGLELGV GEKLCIRAIA RASGAKADEI EELYKKTGDM GEAARRALSR
110 120 130 140 150
RQAQTLLAFA GGRKAGLSIS QVYDTLFKVA KASGEGSQDL KISLLSSLFS
160 170 180 190 200
QLSPDEAKYV ARFVVGRLRL GVADMTVIDA LAEAFGVPEE ALERAYNVRP
210 220 230 240 250
DLGFLGKLVA ERGAAGLAEV RITPGVPVMP MLAQRLSTSR EILAKLGGAA
260 270 280 290 300
ICEYKYDGER AQIHVSPDGV AIYSRRLENI THAYPDVVES VRKSVSAREA
310 320 330 340 350
VLEGEIVAVD PDTGDLLPFQ ELMHRKRKHE VEEAVKEYPA KLNLFDLLYL
360 370 380 390 400
DGEDLTDKPL MYRRLKLSEI VEEGEDVVIA KWALFDDEEK VDVFFHEAIS
410 420 430 440 450
MGMEGLVCKS PTSVYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR
460 470 480 490 500
GKRAGLYGAF LTAAYDPKTD TFYTVCKVGS GFTDADLKKM YQMLEPYKID
510 520 530 540 550
HRHPRVSSRM EPDVWFTPGV VLEIIGAEIT LSPLHTCCLG AVRPDVGLAI
560 570 580 590
RFPRFTGRYR TDKSPEEATT VDELLEMYKS QKKVKVEQGP EAAP
Length:594
Mass (Da):65,973
Last modified:May 31, 2011 - v1
Checksum:i853AA43A566CE3AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002590 Genomic DNA Translation: AEA13078.1
RefSeqiWP_013680413.1, NC_015315.1

Genome annotation databases

EnsemblBacteriaiAEA13078; AEA13078; TUZN_1611
GeneIDi10361131
KEGGituz:TUZN_1611

Similar proteinsi

Entry informationi

Entry nameiF2L2N0_THEU7
AccessioniPrimary (citable) accession number: F2L2N0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health