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Protein

Alanine racemase

Gene

alr

Organism
Prevotella denticola (strain F0289)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei496Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei594SubstrateUniRule annotation1
Active sitei721Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei770Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HMPREF9137_2283Imported
OrganismiPrevotella denticola (strain F0289)Imported
Taxonomic identifieri767031 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
Proteomesi
  • UP000008137 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei496N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi767031.HMPREF9137_2283.

Structurei

3D structure databases

ProteinModelPortaliF2KY71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini700 – 824Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
KOiK01775.
OMAiMVKAFAY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

F2KY71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTIEKVTT LIGARRYGDK DADISFVLTD SRSLCFPEET LFFALKSERN
60 70 80 90 100
DGHNYIPELY GRGVRNFVVE TVPEDWNKRY PDSNFLKVVG SLEALQRLAE
110 120 130 140 150
RHRDEYLIPV VGITGSNGKT MVKEWLYQLL SPQMVVTRSP RSYNSQIGVP
160 170 180 190 200
LSVLLLNENT QVGVFEAGIS QPGEMSALRD IIQPTIGVFT CLGSAHQENF
210 220 230 240 250
PSLEAKCKEK LHLFHDTQAI VYSLDDEVLN RCLDEYDYKG EKLCWSAKDE
260 270 280 290 300
KAVFYIKSIE KKDVETTVTY TWKNGKEAQY RLPFIDDASV ENSITCAVTA
310 320 330 340 350
LQLGVTPAAL GERMAQLEPV AMRLEVKEGQ HGCTLINDSY NSDFNSLDIA
360 370 380 390 400
LDFMNRRPDH KGRRRTLILS DILQSGDTDK DLYNKVAFLC EKRGVEKFIG
410 420 430 440 450
IGEGLLGQRS AFRHLGKKHF FATVNAFIHS DVFANLHDEV ILLKGARQFG
460 470 480 490 500
FDRLTELLVK KVHETVLEVN LNAVVDNLNW YRSFLKPETK LVCMIKADAY
510 520 530 540 550
GAGAVEIAKT LQDHRVDYLA VAVADEGVTL RKNGITSNIM IMNPEMSSFK
560 570 580 590 600
TLFDYDLEPE VYCFRLLDAL VKAAQKEGIT GFPVHIKLDT GMHRLGFDPQ
610 620 630 640 650
KDMDELISRL KHQNAIIPRS VFSHFVGSDA DSFDGFSARQ FALFEEGSGK
660 670 680 690 700
LQSAFKHKII RHMDNSAGIE HFPERQMDMC RLGLGLYGIN PRTNKIINNV
710 720 730 740 750
STLKTTILQL RHVPAGDTVG YSRKGTIEHD SLIAAIPIGY ADGLNRHLGN
760 770 780 790 800
RHCYCLVNGK KAAYVGNICM DVAMIDVTGI DCKEGDSVEI FGDHLPVTVL
810 820
SDVLDTIPYE VLTTVSNRVK RVYFQD
Length:826
Mass (Da):92,865
Last modified:May 31, 2011 - v1
Checksum:i3B48D3F8F10375F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002589 Genomic DNA. Translation: AEA21505.1.
RefSeqiWP_004353807.1. NC_015311.1.

Genome annotation databases

EnsemblBacteriaiAEA21505; AEA21505; HMPREF9137_2283.
KEGGipdn:HMPREF9137_2283.
PATRICi54410162. VBIPreDen163057_2306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002589 Genomic DNA. Translation: AEA21505.1.
RefSeqiWP_004353807.1. NC_015311.1.

3D structure databases

ProteinModelPortaliF2KY71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi767031.HMPREF9137_2283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA21505; AEA21505; HMPREF9137_2283.
KEGGipdn:HMPREF9137_2283.
PATRICi54410162. VBIPreDen163057_2306.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
KOiK01775.
OMAiMVKAFAY.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF2KY71_PREDF
AccessioniPrimary (citable) accession number: F2KY71
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 15, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.