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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151Proton acceptorUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Metal bindingi177Magnesium; via carbamate groupUniRule annotation1
Metal bindingi179MagnesiumUniRule annotation1
Metal bindingi180MagnesiumUniRule annotation1
Active sitei269Proton acceptorUniRule annotation1
Binding sitei270SubstrateUniRule annotation1
Binding sitei302SubstrateUniRule annotation1
Sitei309Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Arcve_0786Imported
OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
Taxonomic identifieri693661 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000008136 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Protein-protein interaction databases

STRINGi693661.Arcve_0786.

Structurei

3D structure databases

ProteinModelPortaliF2KRW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 120RuBisCO_large_NInterPro annotationAdd BLAST113
Domaini130 – 409RuBisCO_largeInterPro annotationAdd BLAST280

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni338 – 340Substrate bindingUniRule annotation3
Regioni360 – 363Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04443. Archaea.
COG1850. LUCA.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

CDDicd08213. RuBisCO_large_III. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3. 1 hit.
InterProiIPR033966. RuBisCO.
IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2KRW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEWYTEFV DLSYEPEENE IICVFRVEPD GISMEEAAGR VASESSVGTW
60 70 80 90 100
TTLAKLPERI KRLMAKVFEI DGNVVKIAYP LDLFEEGSIP QLLSSVAGNV
110 120 130 140 150
FGMKALKNLR LEDIEFPAEY CKHFSGPLLG IEGVRKLFGV YDRPLTATVP
160 170 180 190 200
KPKVGFDADE YADIAYQGWS GGIDFIKDDE NLTSQPFVRF EKRLEKVMKA
210 220 230 240 250
REKAEKETGE KKVYLANVTA VGKEMLRRAK LVADYGNEYV MVDILTAGFS
260 270 280 290 300
AVQMLREECE DLGLGIHAHR AMHAAFTRNP KHGISLDVLV KISRLAGVDN
310 320 330 340 350
FHVGTGVGKM EGSKDMVKRL ADICRREWYV KPVFPVSSGG LHPGLVPDIV
360 370 380 390 400
QLFGKDVIIQ AGGGVHGHPD GTHAGAKALR QAIDAVIKGI SLDEHAKKHA
410
ELARALEKWG YTRPK
Length:415
Mass (Da):45,962
Last modified:May 31, 2011 - v1
Checksum:i74680EC3F2F95AF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002588 Genomic DNA. Translation: AEA46802.1.
RefSeqiWP_013683474.1. NC_015320.1.

Genome annotation databases

EnsemblBacteriaiAEA46802; AEA46802; Arcve_0786.
GeneIDi10393889.
KEGGiave:Arcve_0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002588 Genomic DNA. Translation: AEA46802.1.
RefSeqiWP_013683474.1. NC_015320.1.

3D structure databases

ProteinModelPortaliF2KRW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi693661.Arcve_0786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA46802; AEA46802; Arcve_0786.
GeneIDi10393889.
KEGGiave:Arcve_0786.

Phylogenomic databases

eggNOGiarCOG04443. Archaea.
COG1850. LUCA.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

CDDicd08213. RuBisCO_large_III. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3. 1 hit.
InterProiIPR033966. RuBisCO.
IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF2KRW1_ARCVS
AccessioniPrimary (citable) accession number: F2KRW1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 30, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.