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F2KRW1

- F2KRW1_ARCVS

UniProt

F2KRW1 - F2KRW1_ARCVS

Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei151 – 1511Proton acceptorUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Metal bindingi177 – 1771Magnesium; via carbamate groupUniRule annotation
    Metal bindingi179 – 1791MagnesiumUniRule annotation
    Metal bindingi180 – 1801MagnesiumUniRule annotation
    Active sitei269 – 2691Proton acceptorUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Binding sitei302 – 3021SubstrateUniRule annotation
    Sitei309 – 3091Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. carbon fixation Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciAVEN693661:GHD5-800-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCOUniRule annotation
    Gene namesi
    Name:rbcLUniRule annotation
    Ordered Locus Names:Arcve_0786Imported
    OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
    Taxonomic identifieri693661 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000008136: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei177 – 1771N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF2KRW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni338 – 3403Substrate bindingUniRule annotation
    Regioni360 – 3634Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family.UniRule annotation
    Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01601.
    OMAiFTQDWAS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProiIPR017712. RuBisCO_III.
    IPR020878. RuBisCo_large_chain_AS.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2KRW1-1 [UniParc]FASTAAdd to Basket

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    MSFEWYTEFV DLSYEPEENE IICVFRVEPD GISMEEAAGR VASESSVGTW    50
    TTLAKLPERI KRLMAKVFEI DGNVVKIAYP LDLFEEGSIP QLLSSVAGNV 100
    FGMKALKNLR LEDIEFPAEY CKHFSGPLLG IEGVRKLFGV YDRPLTATVP 150
    KPKVGFDADE YADIAYQGWS GGIDFIKDDE NLTSQPFVRF EKRLEKVMKA 200
    REKAEKETGE KKVYLANVTA VGKEMLRRAK LVADYGNEYV MVDILTAGFS 250
    AVQMLREECE DLGLGIHAHR AMHAAFTRNP KHGISLDVLV KISRLAGVDN 300
    FHVGTGVGKM EGSKDMVKRL ADICRREWYV KPVFPVSSGG LHPGLVPDIV 350
    QLFGKDVIIQ AGGGVHGHPD GTHAGAKALR QAIDAVIKGI SLDEHAKKHA 400
    ELARALEKWG YTRPK 415
    Length:415
    Mass (Da):45,962
    Last modified:May 31, 2011 - v1
    Checksum:i74680EC3F2F95AF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002588 Genomic DNA. Translation: AEA46802.1.
    RefSeqiWP_013683474.1. NC_015320.1.
    YP_004341517.1. NC_015320.1.

    Genome annotation databases

    EnsemblBacteriaiAEA46802; AEA46802; Arcve_0786.
    GeneIDi10393889.
    KEGGiave:Arcve_0786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002588 Genomic DNA. Translation: AEA46802.1 .
    RefSeqi WP_013683474.1. NC_015320.1.
    YP_004341517.1. NC_015320.1.

    3D structure databases

    ProteinModelPortali F2KRW1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA46802 ; AEA46802 ; Arcve_0786 .
    GeneIDi 10393889.
    KEGGi ave:Arcve_0786.

    Phylogenomic databases

    KOi K01601.
    OMAi FTQDWAS.

    Enzyme and pathway databases

    BioCyci AVEN693661:GHD5-800-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProi IPR017712. RuBisCO_III.
    IPR020878. RuBisCo_large_chain_AS.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SNP6.

    Entry informationi

    Entry nameiF2KRW1_ARCVS
    AccessioniPrimary (citable) accession number: F2KRW1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3