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F2KQN9

- F2KQN9_ARCVS

UniProt

F2KQN9 - F2KQN9_ARCVS

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Protein

DNA ligase

Gene

lig

Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471ATPUniRule annotation
Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
Binding sitei254 – 2541ATPUniRule annotation
Binding sitei269 – 2691ATPUniRule annotation
Binding sitei298 – 2981ATPUniRule annotation
Binding sitei337 – 3371ATPUniRule annotation
Binding sitei412 – 4121ATPUniRule annotation
Binding sitei418 – 4181ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVEN693661:GHD5-587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Arcve_0580Imported
OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
Taxonomic identifieri693661 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000008136: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF2KQN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2KQN9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFKEFAEFC SVIEKISSTL ELAARIAAFI KGIEDDNDLY NVVLFLMGKV
60 70 80 90 100
YPPWDERELG VGVGLIYEAL RVATGTNRSK IEELIKETGD LGIAAEKLLQ
110 120 130 140 150
TKTQLTLFEE ELTVAKVREV FDTMSSLTGE GSQKRKIRLL ADLYFSATPI
160 170 180 190 200
EARYLTRLIL SEMRLGVGEG IVRDAIARAW GIEEALVERA YMITNDFGKV
210 220 230 240 250
AVVAKNEGKE GLEKMKIELH VPVRMMLAQV AESIDQAIRE MSRVAVEWKF
260 270 280 290 300
DGTRVQVHWG NGKVTIYSRR LENVTRALPE IVEEIKSNVK EGVILDGEVV
310 320 330 340 350
AMKEGRPMPF QHILRRFRRK YEVSKMMEKI PIHAQFFDIL YCDGKEVIDL
360 370 380 390 400
PLEERRKLLE SVVRSSDRIW VAKQVVTSDA AVIEQVYNEA LNAGHEGAML
410 420 430 440 450
KNPKSPYIPG KRGKHWLKLK PVMETLDLVV IGGEWGEGKR SHVISSYEIA
460 470 480 490 500
CLDPTTGKLL PVGKVATGFT DEELEEFTEL FRPLIEYEEG KKIVLQPKYV
510 520 530 540 550
FEVAYQEIQK SPKYESGYAL RFPRFVRLRE DKDVGEADTI DRVARLYESQ

FKGKKT
Length:556
Mass (Da):63,264
Last modified:May 31, 2011 - v1
Checksum:iDC69C05CFA89E020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002588 Genomic DNA. Translation: AEA46601.1.
RefSeqiWP_013683275.1. NC_015320.1.
YP_004341316.1. NC_015320.1.

Genome annotation databases

EnsemblBacteriaiAEA46601; AEA46601; Arcve_0580.
GeneIDi10393676.
KEGGiave:Arcve_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002588 Genomic DNA. Translation: AEA46601.1 .
RefSeqi WP_013683275.1. NC_015320.1.
YP_004341316.1. NC_015320.1.

3D structure databases

ProteinModelPortali F2KQN9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA46601 ; AEA46601 ; Arcve_0580 .
GeneIDi 10393676.
KEGGi ave:Arcve_0580.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci AVEN693661:GHD5-587-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SNP6.

Entry informationi

Entry nameiF2KQN9_ARCVS
AccessioniPrimary (citable) accession number: F2KQN9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3