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F2KQN9 (F2KQN9_ARCVS) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Arcve_0580 EMBL AEA46601.1
OrganismArchaeoglobus veneficus (strain DSM 11195 / SNP6) [Complete proteome] [HAMAP] EMBL AEA46601.1
Taxonomic identifier693661 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2491N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2471ATP By similarity HAMAP-Rule MF_00407
Binding site2541ATP By similarity HAMAP-Rule MF_00407
Binding site2691ATP By similarity HAMAP-Rule MF_00407
Binding site2981ATP By similarity HAMAP-Rule MF_00407
Binding site3371ATP By similarity HAMAP-Rule MF_00407
Binding site4121ATP By similarity HAMAP-Rule MF_00407
Binding site4181ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F2KQN9 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: DC69C05CFA89E020

FASTA55663,264
        10         20         30         40         50         60 
MLFKEFAEFC SVIEKISSTL ELAARIAAFI KGIEDDNDLY NVVLFLMGKV YPPWDERELG 

        70         80         90        100        110        120 
VGVGLIYEAL RVATGTNRSK IEELIKETGD LGIAAEKLLQ TKTQLTLFEE ELTVAKVREV 

       130        140        150        160        170        180 
FDTMSSLTGE GSQKRKIRLL ADLYFSATPI EARYLTRLIL SEMRLGVGEG IVRDAIARAW 

       190        200        210        220        230        240 
GIEEALVERA YMITNDFGKV AVVAKNEGKE GLEKMKIELH VPVRMMLAQV AESIDQAIRE 

       250        260        270        280        290        300 
MSRVAVEWKF DGTRVQVHWG NGKVTIYSRR LENVTRALPE IVEEIKSNVK EGVILDGEVV 

       310        320        330        340        350        360 
AMKEGRPMPF QHILRRFRRK YEVSKMMEKI PIHAQFFDIL YCDGKEVIDL PLEERRKLLE 

       370        380        390        400        410        420 
SVVRSSDRIW VAKQVVTSDA AVIEQVYNEA LNAGHEGAML KNPKSPYIPG KRGKHWLKLK 

       430        440        450        460        470        480 
PVMETLDLVV IGGEWGEGKR SHVISSYEIA CLDPTTGKLL PVGKVATGFT DEELEEFTEL 

       490        500        510        520        530        540 
FRPLIEYEEG KKIVLQPKYV FEVAYQEIQK SPKYESGYAL RFPRFVRLRE DKDVGEADTI 

       550 
DRVARLYESQ FKGKKT 

« Hide

References

[1]"The complete genome of Archaeoglobus veneficus SNP6."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Lu M., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SNP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002588 Genomic DNA. Translation: AEA46601.1.
RefSeqYP_004341316.1. NC_015320.1.

3D structure databases

ProteinModelPortalF2KQN9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA46601; AEA46601; Arcve_0580.
GeneID10393676.
KEGGave:Arcve_0580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMAGRPRPFQ.

Enzyme and pathway databases

BioCycAVEN693661:GHD5-587-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2KQN9_ARCVS
AccessionPrimary (citable) accession number: F2KQN9
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)