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F2KQN9

- F2KQN9_ARCVS

UniProt

F2KQN9 - F2KQN9_ARCVS

Protein

DNA ligase

Gene

lig

Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei247 – 2471ATPUniRule annotation
    Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
    Binding sitei254 – 2541ATPUniRule annotation
    Binding sitei269 – 2691ATPUniRule annotation
    Binding sitei298 – 2981ATPUniRule annotation
    Binding sitei337 – 3371ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVEN693661:GHD5-587-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Arcve_0580Imported
    OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
    Taxonomic identifieri693661 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000008136: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF2KQN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2KQN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFKEFAEFC SVIEKISSTL ELAARIAAFI KGIEDDNDLY NVVLFLMGKV    50
    YPPWDERELG VGVGLIYEAL RVATGTNRSK IEELIKETGD LGIAAEKLLQ 100
    TKTQLTLFEE ELTVAKVREV FDTMSSLTGE GSQKRKIRLL ADLYFSATPI 150
    EARYLTRLIL SEMRLGVGEG IVRDAIARAW GIEEALVERA YMITNDFGKV 200
    AVVAKNEGKE GLEKMKIELH VPVRMMLAQV AESIDQAIRE MSRVAVEWKF 250
    DGTRVQVHWG NGKVTIYSRR LENVTRALPE IVEEIKSNVK EGVILDGEVV 300
    AMKEGRPMPF QHILRRFRRK YEVSKMMEKI PIHAQFFDIL YCDGKEVIDL 350
    PLEERRKLLE SVVRSSDRIW VAKQVVTSDA AVIEQVYNEA LNAGHEGAML 400
    KNPKSPYIPG KRGKHWLKLK PVMETLDLVV IGGEWGEGKR SHVISSYEIA 450
    CLDPTTGKLL PVGKVATGFT DEELEEFTEL FRPLIEYEEG KKIVLQPKYV 500
    FEVAYQEIQK SPKYESGYAL RFPRFVRLRE DKDVGEADTI DRVARLYESQ 550
    FKGKKT 556
    Length:556
    Mass (Da):63,264
    Last modified:May 31, 2011 - v1
    Checksum:iDC69C05CFA89E020
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002588 Genomic DNA. Translation: AEA46601.1.
    RefSeqiWP_013683275.1. NC_015320.1.
    YP_004341316.1. NC_015320.1.

    Genome annotation databases

    EnsemblBacteriaiAEA46601; AEA46601; Arcve_0580.
    GeneIDi10393676.
    KEGGiave:Arcve_0580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002588 Genomic DNA. Translation: AEA46601.1 .
    RefSeqi WP_013683275.1. NC_015320.1.
    YP_004341316.1. NC_015320.1.

    3D structure databases

    ProteinModelPortali F2KQN9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA46601 ; AEA46601 ; Arcve_0580 .
    GeneIDi 10393676.
    KEGGi ave:Arcve_0580.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci AVEN693661:GHD5-587-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SNP6.

    Entry informationi

    Entry nameiF2KQN9_ARCVS
    AccessioniPrimary (citable) accession number: F2KQN9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3