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F2KQN9

- F2KQN9_ARCVS

UniProt

F2KQN9 - F2KQN9_ARCVS

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Protein
DNA ligase
Gene
lig, Arcve_0580
Organism
Archaeoglobus veneficus (strain DSM 11195 / SNP6)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471ATP By similarityUniRule annotation
Active sitei249 – 2491N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei254 – 2541ATP By similarityUniRule annotation
Binding sitei269 – 2691ATP By similarityUniRule annotation
Binding sitei298 – 2981ATP By similarityUniRule annotation
Binding sitei337 – 3371ATP By similarityUniRule annotation
Binding sitei412 – 4121ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVEN693661:GHD5-587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Arcve_0580Imported
OrganismiArchaeoglobus veneficus (strain DSM 11195 / SNP6)Imported
Taxonomic identifieri693661 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000008136: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF2KQN9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2KQN9-1 [UniParc]FASTAAdd to Basket

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MLFKEFAEFC SVIEKISSTL ELAARIAAFI KGIEDDNDLY NVVLFLMGKV    50
YPPWDERELG VGVGLIYEAL RVATGTNRSK IEELIKETGD LGIAAEKLLQ 100
TKTQLTLFEE ELTVAKVREV FDTMSSLTGE GSQKRKIRLL ADLYFSATPI 150
EARYLTRLIL SEMRLGVGEG IVRDAIARAW GIEEALVERA YMITNDFGKV 200
AVVAKNEGKE GLEKMKIELH VPVRMMLAQV AESIDQAIRE MSRVAVEWKF 250
DGTRVQVHWG NGKVTIYSRR LENVTRALPE IVEEIKSNVK EGVILDGEVV 300
AMKEGRPMPF QHILRRFRRK YEVSKMMEKI PIHAQFFDIL YCDGKEVIDL 350
PLEERRKLLE SVVRSSDRIW VAKQVVTSDA AVIEQVYNEA LNAGHEGAML 400
KNPKSPYIPG KRGKHWLKLK PVMETLDLVV IGGEWGEGKR SHVISSYEIA 450
CLDPTTGKLL PVGKVATGFT DEELEEFTEL FRPLIEYEEG KKIVLQPKYV 500
FEVAYQEIQK SPKYESGYAL RFPRFVRLRE DKDVGEADTI DRVARLYESQ 550
FKGKKT 556
Length:556
Mass (Da):63,264
Last modified:May 31, 2011 - v1
Checksum:iDC69C05CFA89E020
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002588 Genomic DNA. Translation: AEA46601.1.
RefSeqiWP_013683275.1. NC_015320.1.
YP_004341316.1. NC_015320.1.

Genome annotation databases

EnsemblBacteriaiAEA46601; AEA46601; Arcve_0580.
GeneIDi10393676.
KEGGiave:Arcve_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002588 Genomic DNA. Translation: AEA46601.1 .
RefSeqi WP_013683275.1. NC_015320.1.
YP_004341316.1. NC_015320.1.

3D structure databases

ProteinModelPortali F2KQN9.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA46601 ; AEA46601 ; Arcve_0580 .
GeneIDi 10393676.
KEGGi ave:Arcve_0580.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci AVEN693661:GHD5-587-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SNP6.

Entry informationi

Entry nameiF2KQN9_ARCVS
AccessioniPrimary (citable) accession number: F2KQN9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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