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F2K2I7

- F2K2I7_MARM1

UniProt

F2K2I7 - F2K2I7_MARM1

Protein

Alanine racemase

Gene

Marme_0749

Organism
Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei255 – 2551Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMMED717774:GCPW-766-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Marme_0749Imported
    OrganismiMarinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)Imported
    Taxonomic identifieri717774 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
    ProteomesiUP000001062: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF2K2I7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiNIRADEM.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2K2I7-1 [UniParc]FASTAAdd to Basket

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    MARPLKAIID LEAIKINYQF SKKLHPTCKA LAVVKSDAYG HGAVDVATYL    50
    DDDVDAFAVA AIEEALQLRE ADVTSPILLL EGVFEQNEWP LCEELGFWCV 100
    IENTTQLDGL LNAQSKIEKV FVKLDTGMHR LGLNSLQVEH VVDTLKASGL 150
    VEEVVLMTHF SCADDLSSLE TIKQLTLFEE ANRTVGHLTT SVANSAAIMK 200
    WSVPEGGWIR PGIMLYGISP FVGVTGTQLG LKPAMQLVSK VISVRDVNIG 250
    DTVGYSQQYT AEHPHQIATV AVGYGDGYPR SSENGTPVAL SGDTAELAGR 300
    VSMDMITVKL SNQASSERPH QERKIQLGEE VELWGEQVPV EEVAYRSGTI 350
    GYELVTRMTQ RPMREYKTTK EQS 373
    Length:373
    Mass (Da):40,925
    Last modified:May 31, 2011 - v1
    Checksum:i2BDDB32F0D415BC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002583 Genomic DNA. Translation: ADZ90032.1.
    RefSeqiYP_004311868.1. NC_015276.1.

    Genome annotation databases

    EnsemblBacteriaiADZ90032; ADZ90032; Marme_0749.
    GeneIDi10334795.
    KEGGimme:Marme_0749.
    PATRICi47226165. VBIMarMed159599_0778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002583 Genomic DNA. Translation: ADZ90032.1 .
    RefSeqi YP_004311868.1. NC_015276.1.

    3D structure databases

    ProteinModelPortali F2K2I7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADZ90032 ; ADZ90032 ; Marme_0749 .
    GeneIDi 10334795.
    KEGGi mme:Marme_0749.
    PATRICi 47226165. VBIMarMed159599_0778.

    Phylogenomic databases

    KOi K01775.
    OMAi NIRADEM.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MMED717774:GCPW-766-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1Imported.

    Entry informationi

    Entry nameiF2K2I7_MARM1
    AccessioniPrimary (citable) accession number: F2K2I7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3