Skip Header

Contribute Send feedback
Read comments (?) or add your own

F2K025 (F2K025_MARM1) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Ordered Locus Names:Marme_4031
OrganismMarinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) [Complete proteome] [HAMAP] EMBL ADZ93239.1
Taxonomic identifier717774 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas ›

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region9 – 146Substrate binding By similarity HAMAP-Rule MF_01405
Region70 – 712Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding411Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding701Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1581Substrate By similarity HAMAP-Rule MF_01405
Binding site1781Substrate By similarity HAMAP-Rule MF_01405
Binding site1841Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
F2K025 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 23CAF42FD632653D

FASTA20222,022
        10         20         30         40         50         60 
MNKTIVLASN NSGKIKEFNS LFSQYGIDVK PQGEFNVEEA DETGLSFIEN AILKARNACA 

        70         80         90        100        110        120 
RTNLPAIADD SGIEVDYLNG APGIYSARFA GEHGDNDANN ALLLEKLDGV PTEQRTARFH 

       130        140        150        160        170        180 
CVLAYMRHKD DPTPIVVQGS WEGRILESNE GVEGFGYDPI FFVPEQGCSS ASLPKEVKNS 

       190        200 
LSHRAKALKL LMAAFKEKSV LA

« Hide

References

[1]"Complete sequence of Marinomonas mediterranea MMB-1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Lucas-Elio P., Johnston A.W.B., Sanchez-Amat A., Woyke T.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002583 Genomic DNA. Translation: ADZ93239.1.
RefSeqYP_004315075.1. NC_015276.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADZ93239; ADZ93239; Marme_4031.
GeneID10338158.
KEGGmme:Marme_4031.
PATRIC47233128. VBIMarMed159599_4159.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK02428.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF2K025_MARM1
AccessionPrimary (citable) accession number: F2K025
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info