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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Marme_1336

Organism
Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451SubstrateUniRule annotation
Sitei254 – 2541Critical for catalysisUniRule annotation
Metal bindingi349 – 3491Magnesium or manganeseUniRule annotation
Sitei419 – 4191Critical for catalysisUniRule annotation
Binding sitei546 – 5461SubstrateUniRule annotation
Metal bindingi547 – 5471Magnesium or manganeseUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMMED717774:GCPW-1368-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Marme_1336Imported
OrganismiMarinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)Imported
Taxonomic identifieri717774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001062 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi717774.Marme_1336.

Structurei

3D structure databases

ProteinModelPortaliF2JWD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F2JWD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKHTIYYTL TDEAPALATA SLLPIFQAFA KEADINLQLT DISLAARVLS
60 70 80 90 100
LFTDRLPEDK QVEDGLSFLG ELTADPDANF IKLPNISASI PQLTATIKEL
110 120 130 140 150
QSQGYEIPDY PEAPATDEEK EINSRYSKVL GSAVNPVLRQ GNSDRRAPAA
160 170 180 190 200
VKGFARKHPH SMGKWQKTSQ THADYMRDGD FFSSEQSVTM DKAQEVRIEF
210 220 230 240 250
VNKSGEVDVK KTLPLLEGEV LDGMRMSASK LRDFFEQSLQ EAKEAGIMWS
260 270 280 290 300
LHVKATMMKV SHPIVFGHAV TVYYKEVWDK FGDLFDELGV NPNNGIGSVY
310 320 330 340 350
DKIKTLPQST QDEILESIHD CYEHRPEIAM VDSVRGITNL HVPSDVIVDA
360 370 380 390 400
SMPAMIRSSG KMWGRDGKTK DTKAVMPEST YARIYQEVIN FCKTNGAFDP
410 420 430 440 450
TTMGTVPNVG LMAQKAEEYG SHDKTFEVQE NGTMRVRDAE GNVLMQHDVE
460 470 480 490 500
KGDIWRACQT KDAPIKDWVK LGVTRARNSG TPAVFWLDAE RAHDNELRKK
510 520 530 540 550
VKLYLQDHDL EGLEIHIMSY NEAIRFSMER MMRGQDTISV SGNVLRDYLT
560 570 580 590 600
DLFPIMELGT SAKMLSIVPM LNGGGMYETG AGGSAPKHVQ QLQEENYLRW
610 620 630 640 650
DSLGEFLATA VSFEELGIKQ DNAKAKVLAA ALDRATEQLL DNNKSPSRKV
660 670 680 690 700
GDIDNRGSHF YLTMYWAQAL ATQTDDAELA DKFASVAKAL VENESKIVEE
710 720 730
LNSVQGKDAG LEGYYHMDLD AVTKVMRPSA TFNEILAAI
Length:739
Mass (Da):82,315
Last modified:May 31, 2011 - v1
Checksum:iE7DAF5E2241CCA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002583 Genomic DNA. Translation: ADZ90609.1.
RefSeqiWP_013660514.1. NC_015276.1.

Genome annotation databases

EnsemblBacteriaiADZ90609; ADZ90609; Marme_1336.
KEGGimme:Marme_1336.
PATRICi47227410. VBIMarMed159599_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002583 Genomic DNA. Translation: ADZ90609.1.
RefSeqiWP_013660514.1. NC_015276.1.

3D structure databases

ProteinModelPortaliF2JWD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi717774.Marme_1336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADZ90609; ADZ90609; Marme_1336.
KEGGimme:Marme_1336.
PATRICi47227410. VBIMarMed159599_1384.

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Enzyme and pathway databases

BioCyciMMED717774:GCPW-1368-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1Imported.

Entry informationi

Entry nameiF2JWD6_MARM1
AccessioniPrimary (citable) accession number: F2JWD6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: July 22, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.