ID   F2J3M0_POLGS            Unreviewed;       288 AA.
AC   F2J3M0;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Probable 6-phosphogluconate dehydrogenase protein {ECO:0000313|EMBL:ADZ72156.1};
GN   OrderedLocusNames=SL003B_3735 {ECO:0000313|EMBL:ADZ72156.1};
OS   Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Polymorphum.
OX   NCBI_TaxID=991905 {ECO:0000313|EMBL:ADZ72156.1, ECO:0000313|Proteomes:UP000008130};
RN   [1] {ECO:0000313|EMBL:ADZ72156.1, ECO:0000313|Proteomes:UP000008130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 25793 / CGMCC 1.9160 / SL003B-26A1
RC   {ECO:0000313|Proteomes:UP000008130};
RX   PubMed=21478361; DOI=10.1128/JB.00333-11;
RA   Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.;
RT   "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-
RT   degrading bacterium from oil-polluted saline soil.";
RL   J. Bacteriol. 193:2894-2895(2011).
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DR   EMBL; CP002568; ADZ72156.1; -; Genomic_DNA.
DR   RefSeq; WP_013654465.1; NC_015259.1.
DR   AlphaFoldDB; F2J3M0; -.
DR   STRING; 991905.SL003B_3735; -.
DR   KEGG; pgv:SL003B_3735; -.
DR   eggNOG; COG2084; Bacteria.
DR   HOGENOM; CLU_035117_1_1_5; -.
DR   OrthoDB; 9812907at2; -.
DR   Proteomes; UP000008130; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008130}.
FT   DOMAIN          2..153
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          156..276
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        162
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   288 AA;  30021 MW;  8A4B06B03E789522 CRC64;
     MKIGFIGLGV MGGAMAGHLA RAGHDLTGFD LSPDAGAGLA RAASAADAVR GAEVVFTMLP
     HGRAVAGVID EILDALPEGC LFVDTSSSEP WLTKQTADRL AARGVTMVDA PVSGASWGAR
     DAQLVFMVGG DDAAVARVRP LLALMGKAAH HVGPLGAGHA MKTINNVITA MTVISTTEAM
     LIGKAYGLIP SAMADVLNVS TGQSFWTTER LKQDVLNRAF KDEFKLTLMR KDVDIANALG
     REMGLELPLL SLGEALWRQA DADLGTGAAV TDMVRWIEGK VGGELTDD
//