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F2IYS4

- F2IYS4_POLGS

UniProt

F2IYS4 - F2IYS4_POLGS

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

SL003B_1092

Organism
Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    MagnesiumSAAS annotation, Metal-bindingSAAS annotation, PyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciPGIL991905:GJ0L-1110-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alphaUniRule annotation (EC:1.2.4.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:SL003B_1092Imported
    OrganismiPolymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)Imported
    Taxonomic identifieri991905 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaPolymorphum
    ProteomesiUP000008130: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: InterPro

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.UniRule annotation

    Family & Domainsi

    Phylogenomic databases

    KOiK11381.
    OMAiMISHLGP.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F2IYS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGTKPHLSR AHALDLLRAM IRIRRFEAKC AELYTQEKIR GFLHLYDGEE    50
    AIAVGVIPLL TERDRIVATY REHGHALARG LPMGAVLAEM YGVAEGCAGG 100
    RGGSMHLFSR EANFYGGNAI VGGGLPLAAG LALADRMRGE DRVTACFFGE 150
    GAVAEGEFHE SLNLASLWQL PVLFVCENNG YAMGTALDLS EAVTDIRAKA 200
    AAYAVDGEVA DGMDVVAVEA ATRRALEAIR DTGRPRFLEC RTYRFRAHSM 250
    FDAQLYRDKA EVEEWRRKGP IVRFQGWLEQ SGLVHVDEIA AIETEVEAEI 300
    AEAVAFSEAG TLEPVEDLTK YVMAPERPLA PTAPAPSAET VETTYREAVR 350
    AAIVDAMTRD ERVFLMGEDV GRYGGCYAVS KGLLSEFGPE RIRDTPLSES 400
    GFTGAGIGAA MAGMRPIVEV MTVNFSLLAL DQILNTAATY RHMSNNQFGV 450
    PVVIRMATGA GRQLAAQHSH SLEGWYAHIP GLRVLAPATL EDARGMLWTA 500
    LQDPDPVLIF ENVMLYNRTG RLAADAGPVD IDRAAVRREG RDLSLVTYGG 550
    SLHKCLEAAE VLAGEGIEAE VVDLRTLRPL DMDTVLASVA RTHRLLVVDE 600
    GWRTGSLAAE IGMQVTERAF YDLDAPPARV CSAEVPIPYA RHLEEASIPQ 650
    VPAIVAAAKS LFGSR 665
    Length:665
    Mass (Da):72,093
    Last modified:May 31, 2011 - v1
    Checksum:i0F4884D7F7130A12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002568 Genomic DNA. Translation: ADZ69521.1.
    RefSeqiWP_013651838.1. NC_015259.1.
    YP_004302821.1. NC_015259.1.

    Genome annotation databases

    EnsemblBacteriaiADZ69521; ADZ69521; SL003B_1092.
    GeneIDi10418431.
    KEGGipgv:SL003B_1092.
    PATRICi47180036. VBIPolGil182274_1113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002568 Genomic DNA. Translation: ADZ69521.1 .
    RefSeqi WP_013651838.1. NC_015259.1.
    YP_004302821.1. NC_015259.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADZ69521 ; ADZ69521 ; SL003B_1092 .
    GeneIDi 10418431.
    KEGGi pgv:SL003B_1092.
    PATRICi 47180036. VBIPolGil182274_1113.

    Phylogenomic databases

    KOi K11381.
    OMAi MISHLGP.

    Enzyme and pathway databases

    BioCyci PGIL991905:GJ0L-1110-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-degrading bacterium from oil-polluted saline soil."
      Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.
      J. Bacteriol. 193:2894-2895(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LMG 25793 / CGMCC 1.9160 / SL003B-26A1Imported.

    Entry informationi

    Entry nameiF2IYS4_POLGS
    AccessioniPrimary (citable) accession number: F2IYS4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3