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F2IYS4

- F2IYS4_POLGS

UniProt

F2IYS4 - F2IYS4_POLGS

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene
SL003B_1092
Organism
Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. pyruvate dehydrogenase (acetyl-transferring) activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

MagnesiumSAAS annotations, Metal-bindingSAAS annotations, PyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciPGIL991905:GJ0L-1110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alphaUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Ordered Locus Names:SL003B_1092Imported
OrganismiPolymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)Imported
Taxonomic identifieri991905 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaPolymorphum
ProteomesiUP000008130: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain By similarity.UniRule annotation

Family & Domainsi

Phylogenomic databases

KOiK11381.
OMAiMISHLGP.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

F2IYS4-1 [UniParc]FASTAAdd to Basket

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MTGTKPHLSR AHALDLLRAM IRIRRFEAKC AELYTQEKIR GFLHLYDGEE    50
AIAVGVIPLL TERDRIVATY REHGHALARG LPMGAVLAEM YGVAEGCAGG 100
RGGSMHLFSR EANFYGGNAI VGGGLPLAAG LALADRMRGE DRVTACFFGE 150
GAVAEGEFHE SLNLASLWQL PVLFVCENNG YAMGTALDLS EAVTDIRAKA 200
AAYAVDGEVA DGMDVVAVEA ATRRALEAIR DTGRPRFLEC RTYRFRAHSM 250
FDAQLYRDKA EVEEWRRKGP IVRFQGWLEQ SGLVHVDEIA AIETEVEAEI 300
AEAVAFSEAG TLEPVEDLTK YVMAPERPLA PTAPAPSAET VETTYREAVR 350
AAIVDAMTRD ERVFLMGEDV GRYGGCYAVS KGLLSEFGPE RIRDTPLSES 400
GFTGAGIGAA MAGMRPIVEV MTVNFSLLAL DQILNTAATY RHMSNNQFGV 450
PVVIRMATGA GRQLAAQHSH SLEGWYAHIP GLRVLAPATL EDARGMLWTA 500
LQDPDPVLIF ENVMLYNRTG RLAADAGPVD IDRAAVRREG RDLSLVTYGG 550
SLHKCLEAAE VLAGEGIEAE VVDLRTLRPL DMDTVLASVA RTHRLLVVDE 600
GWRTGSLAAE IGMQVTERAF YDLDAPPARV CSAEVPIPYA RHLEEASIPQ 650
VPAIVAAAKS LFGSR 665
Length:665
Mass (Da):72,093
Last modified:May 31, 2011 - v1
Checksum:i0F4884D7F7130A12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002568 Genomic DNA. Translation: ADZ69521.1.
RefSeqiWP_013651838.1. NC_015259.1.
YP_004302821.1. NC_015259.1.

Genome annotation databases

EnsemblBacteriaiADZ69521; ADZ69521; SL003B_1092.
GeneIDi10418431.
KEGGipgv:SL003B_1092.
PATRICi47180036. VBIPolGil182274_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002568 Genomic DNA. Translation: ADZ69521.1 .
RefSeqi WP_013651838.1. NC_015259.1.
YP_004302821.1. NC_015259.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ69521 ; ADZ69521 ; SL003B_1092 .
GeneIDi 10418431.
KEGGi pgv:SL003B_1092.
PATRICi 47180036. VBIPolGil182274_1113.

Phylogenomic databases

KOi K11381.
OMAi MISHLGP.

Enzyme and pathway databases

BioCyci PGIL991905:GJ0L-1110-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-degrading bacterium from oil-polluted saline soil."
    Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.
    J. Bacteriol. 193:2894-2895(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LMG 25793 / CGMCC 1.9160 / SL003B-26A1.

Entry informationi

Entry nameiF2IYS4_POLGS
AccessioniPrimary (citable) accession number: F2IYS4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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