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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

MagnesiumSAAS annotation, Metal-bindingSAAS annotation, PyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciPGIL991905:GJ0L-1110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alphaUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Name:pdhAUniRule annotation
Ordered Locus Names:SL003B_1092Imported
OrganismiPolymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)Imported
Taxonomic identifieri991905 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaPolymorphum
ProteomesiUP000008130 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.UniRule annotation

Protein-protein interaction databases

STRINGi991905.SL003B_1092.

Family & Domainsi

Phylogenomic databases

KOiK11381.
OMAiIALYMTK.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

F2IYS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGTKPHLSR AHALDLLRAM IRIRRFEAKC AELYTQEKIR GFLHLYDGEE
60 70 80 90 100
AIAVGVIPLL TERDRIVATY REHGHALARG LPMGAVLAEM YGVAEGCAGG
110 120 130 140 150
RGGSMHLFSR EANFYGGNAI VGGGLPLAAG LALADRMRGE DRVTACFFGE
160 170 180 190 200
GAVAEGEFHE SLNLASLWQL PVLFVCENNG YAMGTALDLS EAVTDIRAKA
210 220 230 240 250
AAYAVDGEVA DGMDVVAVEA ATRRALEAIR DTGRPRFLEC RTYRFRAHSM
260 270 280 290 300
FDAQLYRDKA EVEEWRRKGP IVRFQGWLEQ SGLVHVDEIA AIETEVEAEI
310 320 330 340 350
AEAVAFSEAG TLEPVEDLTK YVMAPERPLA PTAPAPSAET VETTYREAVR
360 370 380 390 400
AAIVDAMTRD ERVFLMGEDV GRYGGCYAVS KGLLSEFGPE RIRDTPLSES
410 420 430 440 450
GFTGAGIGAA MAGMRPIVEV MTVNFSLLAL DQILNTAATY RHMSNNQFGV
460 470 480 490 500
PVVIRMATGA GRQLAAQHSH SLEGWYAHIP GLRVLAPATL EDARGMLWTA
510 520 530 540 550
LQDPDPVLIF ENVMLYNRTG RLAADAGPVD IDRAAVRREG RDLSLVTYGG
560 570 580 590 600
SLHKCLEAAE VLAGEGIEAE VVDLRTLRPL DMDTVLASVA RTHRLLVVDE
610 620 630 640 650
GWRTGSLAAE IGMQVTERAF YDLDAPPARV CSAEVPIPYA RHLEEASIPQ
660
VPAIVAAAKS LFGSR
Length:665
Mass (Da):72,093
Last modified:May 31, 2011 - v1
Checksum:i0F4884D7F7130A12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002568 Genomic DNA. Translation: ADZ69521.1.
RefSeqiWP_013651838.1. NC_015259.1.
YP_004302821.1. NC_015259.1.

Genome annotation databases

EnsemblBacteriaiADZ69521; ADZ69521; SL003B_1092.
KEGGipgv:SL003B_1092.
PATRICi47180036. VBIPolGil182274_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002568 Genomic DNA. Translation: ADZ69521.1.
RefSeqiWP_013651838.1. NC_015259.1.
YP_004302821.1. NC_015259.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi991905.SL003B_1092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADZ69521; ADZ69521; SL003B_1092.
KEGGipgv:SL003B_1092.
PATRICi47180036. VBIPolGil182274_1113.

Phylogenomic databases

KOiK11381.
OMAiIALYMTK.

Enzyme and pathway databases

BioCyciPGIL991905:GJ0L-1110-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-degrading bacterium from oil-polluted saline soil."
    Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.
    J. Bacteriol. 193:2894-2895(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LMG 25793 / CGMCC 1.9160 / SL003B-26A1Imported.

Entry informationi

Entry nameiF2IYS4_POLGS
AccessioniPrimary (citable) accession number: F2IYS4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.