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F2ICQ8

- F2ICQ8_FLUTR

UniProt

F2ICQ8 - F2ICQ8_FLUTR

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Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene
menD, Fluta_0276
Organism
Fluviicola taffensis (strain DSM 16823 / RW262 / RW262)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotations

Cofactori

Binds 1 thiamine pyrophosphate per subunit By similarity.UniRule annotationSAAS annotations
Magnesium or manganese By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotations

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciFTAF755732:GHMH-280-MONOMER.
UniPathwayiUPA00079; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
Short name:
SEPHCHC synthaseUniRule annotation
Alternative name(s):
Menaquinone biosynthesis protein MenD
Gene namesi
Name:menDUniRule annotation
Ordered Locus Names:Fluta_0276Imported
OrganismiFluviicola taffensis (strain DSM 16823 / RW262 / RW262)Imported
Taxonomic identifieri755732 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCryomorphaceaeFluviicola
ProteomesiUP000007463: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

Phylogenomic databases

KOiK02551.
OMAiQKPWLLE.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01659. MenD.
InterProiIPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view]
PfamiPF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

F2ICQ8-1 [UniParc]FASTAAdd to Basket

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MISSAKLEVQ LLVDGCKKVG VTHVVISPGS RNAPLSIAFD EDPDFQVFVV    50
PDERVAAFYA LGMAQKLNQP VVITCTSGSA PLNYYPAIAE AFYQEIPLIV 100
LSADRPAEWL DQGDGQTIRQ EGVFNQMVLN SAQLNEIHTD NQRWYFERKL 150
SEALQTAVGN RKGPIHLNIP FSEPLYETTS DIQAMSNWIE LAETECVLTK 200
NSRSKLESIW SNSEKRLIIV GQQQNDSHLQ ELLESLALDG SVAVLVEHTS 250
NLFSPYFVSN IDRALNIIPE SDLSSFYPDC IVTIGGAIIS KKIKVFLRQS 300
KAPVIRFGVD FPFMDTFQNL KFTASISAIS GIQLFHSFIK EKPHKSRFGF 350
AWKKIDQFGA EEQKQICNAQ PWSDLKAMEF VMDVIPDQCN LHISNSSLIR 400
YALLFDPIKT LKYWCNRGTS GIDGSSSTAV GSAIVSSKES HVLVTGDLSF 450
FYDSNAWWSK YLPSNLRIIL VNNGGGDIFN IIPGPKSTNQ WKKIFVAEQE 500
LSAENIAKTY GLDYFEASSL SDLEGNLELF FGESSNDKPK ILEINTMNEQ 550
NSAVLETYFK SFKKRV 566
Length:566
Mass (Da):63,290
Last modified:May 31, 2011 - v1
Checksum:iDBC47A1D603F31D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002542 Genomic DNA. Translation: AEA42285.1.
RefSeqiWP_013685059.1. NC_015321.1.
YP_004343123.1. NC_015321.1.

Genome annotation databases

EnsemblBacteriaiAEA42285; AEA42285; Fluta_0276.
GeneIDi10395605.
KEGGifte:Fluta_0276.
PATRICi54414798. VBIFluTaf147081_0274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002542 Genomic DNA. Translation: AEA42285.1 .
RefSeqi WP_013685059.1. NC_015321.1.
YP_004343123.1. NC_015321.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEA42285 ; AEA42285 ; Fluta_0276 .
GeneIDi 10395605.
KEGGi fte:Fluta_0276.
PATRICi 54414798. VBIFluTaf147081_0274.

Phylogenomic databases

KOi K02551.
OMAi QKPWLLE.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00164 .
BioCyci FTAF755732:GHMH-280-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01659. MenD.
InterProi IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view ]
Pfami PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004983. MenD. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00173. menD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16823 / RW262 / RW262.

Entry informationi

Entry nameiF2ICQ8_FLUTR
AccessioniPrimary (citable) accession number: F2ICQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3