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F2ICQ8

- F2ICQ8_FLUTR

UniProt

F2ICQ8 - F2ICQ8_FLUTR

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Fluviicola taffensis (strain DSM 16823 / RW262 / RW262)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotationSAAS annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 thiamine pyrophosphate per subunit.UniRule annotationSAAS annotation
    Magnesium or manganese.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Menaquinone biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciFTAF755732:GHMH-280-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:Fluta_0276Imported
    OrganismiFluviicola taffensis (strain DSM 16823 / RW262 / RW262)Imported
    Taxonomic identifieri755732 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCryomorphaceaeFluviicola
    ProteomesiUP000007463: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    KOiK02551.
    OMAiQKPWLLE.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view]
    PfamiPF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F2ICQ8-1 [UniParc]FASTAAdd to Basket

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    MISSAKLEVQ LLVDGCKKVG VTHVVISPGS RNAPLSIAFD EDPDFQVFVV    50
    PDERVAAFYA LGMAQKLNQP VVITCTSGSA PLNYYPAIAE AFYQEIPLIV 100
    LSADRPAEWL DQGDGQTIRQ EGVFNQMVLN SAQLNEIHTD NQRWYFERKL 150
    SEALQTAVGN RKGPIHLNIP FSEPLYETTS DIQAMSNWIE LAETECVLTK 200
    NSRSKLESIW SNSEKRLIIV GQQQNDSHLQ ELLESLALDG SVAVLVEHTS 250
    NLFSPYFVSN IDRALNIIPE SDLSSFYPDC IVTIGGAIIS KKIKVFLRQS 300
    KAPVIRFGVD FPFMDTFQNL KFTASISAIS GIQLFHSFIK EKPHKSRFGF 350
    AWKKIDQFGA EEQKQICNAQ PWSDLKAMEF VMDVIPDQCN LHISNSSLIR 400
    YALLFDPIKT LKYWCNRGTS GIDGSSSTAV GSAIVSSKES HVLVTGDLSF 450
    FYDSNAWWSK YLPSNLRIIL VNNGGGDIFN IIPGPKSTNQ WKKIFVAEQE 500
    LSAENIAKTY GLDYFEASSL SDLEGNLELF FGESSNDKPK ILEINTMNEQ 550
    NSAVLETYFK SFKKRV 566
    Length:566
    Mass (Da):63,290
    Last modified:May 31, 2011 - v1
    Checksum:iDBC47A1D603F31D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002542 Genomic DNA. Translation: AEA42285.1.
    RefSeqiWP_013685059.1. NC_015321.1.
    YP_004343123.1. NC_015321.1.

    Genome annotation databases

    EnsemblBacteriaiAEA42285; AEA42285; Fluta_0276.
    GeneIDi10395605.
    KEGGifte:Fluta_0276.
    PATRICi54414798. VBIFluTaf147081_0274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002542 Genomic DNA. Translation: AEA42285.1 .
    RefSeqi WP_013685059.1. NC_015321.1.
    YP_004343123.1. NC_015321.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA42285 ; AEA42285 ; Fluta_0276 .
    GeneIDi 10395605.
    KEGGi fte:Fluta_0276.
    PATRICi 54414798. VBIFluTaf147081_0274.

    Phylogenomic databases

    KOi K02551.
    OMAi QKPWLLE.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci FTAF755732:GHMH-280-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view ]
    Pfami PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16823 / RW262 / RW262Imported.

    Entry informationi

    Entry nameiF2ICQ8_FLUTR
    AccessioniPrimary (citable) accession number: F2ICQ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3