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F2ICQ8 (F2ICQ8_FLUTR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase HAMAP-Rule MF_01659

Short name=SEPHCHC synthase HAMAP-Rule MF_01659
EC=2.2.1.9 HAMAP-Rule MF_01659
Alternative name(s):
Menaquinone biosynthesis protein MenD HAMAP-Rule MF_01659
Gene names
Name:menD HAMAP-Rule MF_01659
Ordered Locus Names:Fluta_0276 EMBL AEA42285.1
OrganismFluviicola taffensis (strain DSM 16823 / RW262 / RW262) [Complete proteome] [HAMAP] EMBL AEA42285.1
Taxonomic identifier755732 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCryomorphaceaeFluviicola

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity. HAMAP-Rule MF_01659

Catalytic activity

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2. HAMAP-Rule MF_01659 SAAS SAAS012001

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Magnesium or manganese By similarity. HAMAP-Rule MF_01659 SAAS SAAS012001

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 2/8. HAMAP-Rule MF_01659

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01659

Sequence similarities

Belongs to the TPP enzyme family. MenD subfamily. HAMAP-Rule MF_01659

Sequences

Sequence LengthMass (Da)Tools
F2ICQ8 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: DBC47A1D603F31D6

FASTA56663,290
        10         20         30         40         50         60 
MISSAKLEVQ LLVDGCKKVG VTHVVISPGS RNAPLSIAFD EDPDFQVFVV PDERVAAFYA 

        70         80         90        100        110        120 
LGMAQKLNQP VVITCTSGSA PLNYYPAIAE AFYQEIPLIV LSADRPAEWL DQGDGQTIRQ 

       130        140        150        160        170        180 
EGVFNQMVLN SAQLNEIHTD NQRWYFERKL SEALQTAVGN RKGPIHLNIP FSEPLYETTS 

       190        200        210        220        230        240 
DIQAMSNWIE LAETECVLTK NSRSKLESIW SNSEKRLIIV GQQQNDSHLQ ELLESLALDG 

       250        260        270        280        290        300 
SVAVLVEHTS NLFSPYFVSN IDRALNIIPE SDLSSFYPDC IVTIGGAIIS KKIKVFLRQS 

       310        320        330        340        350        360 
KAPVIRFGVD FPFMDTFQNL KFTASISAIS GIQLFHSFIK EKPHKSRFGF AWKKIDQFGA 

       370        380        390        400        410        420 
EEQKQICNAQ PWSDLKAMEF VMDVIPDQCN LHISNSSLIR YALLFDPIKT LKYWCNRGTS 

       430        440        450        460        470        480 
GIDGSSSTAV GSAIVSSKES HVLVTGDLSF FYDSNAWWSK YLPSNLRIIL VNNGGGDIFN 

       490        500        510        520        530        540 
IIPGPKSTNQ WKKIFVAEQE LSAENIAKTY GLDYFEASSL SDLEGNLELF FGESSNDKPK 

       550        560 
ILEINTMNEQ NSAVLETYFK SFKKRV 

« Hide

References

[1]"The complete genome of Fluviicola taffensis DSM 16823."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Pagani I., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 16823 / RW262 / RW262.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002542 Genomic DNA. Translation: AEA42285.1.
RefSeqYP_004343123.1. NC_015321.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA42285; AEA42285; Fluta_0276.
GeneID10395605.
KEGGfte:Fluta_0276.
PATRIC54414798. VBIFluTaf147081_0274.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK02551.
OMADGGGIFH.

Enzyme and pathway databases

BioCycFTAF755732:GHMH-280-MONOMER.
UniPathwayUPA00079; UER00164.

Family and domain databases

HAMAPMF_01659. MenD.
InterProIPR004433. MenaQ_synth_MenD.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view]
PfamPF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFPIRSF004983. MenD. 1 hit.
TIGRFAMsTIGR00173. menD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF2ICQ8_FLUTR
AccessionPrimary (citable) accession number: F2ICQ8
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)