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F2I0U8 (F2I0U8_PELSM) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:SAR11G3_00909 EMBL AEA81383.1
OrganismPelagibacter sp. (strain IMCC9063) [Complete proteome] [HAMAP] EMBL AEA81383.1
Taxonomic identifier1002672 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
F2I0U8 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 18C44D8B65A72FF1

FASTA40445,793
        10         20         30         40         50         60 
MAKIKVKNPV VELDGDEMTR IIWEFIKNKL ILPYLDVELK YFDLGMESRD KTDDQITIDS 

        70         80         90        100        110        120 
ANEIKKYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGTIFRE PIIMKNVPRL 

       130        140        150        160        170        180 
VPGWTDPIVI GRHAYGDQYR ATDFKVPGKG KLTVKWTSED GNDTVEHDVF DFPGSGIAMT 

       190        200        210        220        230        240 
MYNLDESIKD FARSCMNYGL LRKWPVYLST KNTILKTYDG RFKDLFQEIF DNEFKDEFAK 

       250        260        270        280        290        300 
HKLTYEHRLI DDMVACAMKW SGGYVWACKN YDGDVQCDTV AQGYGSLGLM TSVLMTPDGK 

       310        320        330        340        350        360 
TVESEAAHGT VTRHYREHQK GNETSTNPVA SIFAWTRGLA HRGKLDGNQE LIDFAHALEQ 

       370        380        390        400 
TCVETVETGE MTKDLAVLVG GEQKFLTTSQ FLEAINKNLQ SKLN 

« Hide

References

[1]"Complete genome sequence of strain IMCC9063, belonging to SAR11 subgroup 3, isolated from the Arctic Ocean."
Oh H.M., Kang I., Lee K., Jang Y., Lim S.I., Cho J.C.
J. Bacteriol. 193:3379-3380(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IMCC9063 EMBL AEA81383.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002511 Genomic DNA. Translation: AEA81383.1.
RefSeqYP_004358122.1. NC_015380.1.

3D structure databases

ProteinModelPortalF2I0U8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA81383; AEA81383; SAR11G3_00909.
GeneID10475911.
KEGGpel:SAR11G3_00909.
PATRIC54521386. VBICanPel201843_0897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycCPEL1002672:GHAA-925-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF2I0U8_PELSM
AccessionPrimary (citable) accession number: F2I0U8
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)