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F2I0U8

- F2I0U8_PELSM

UniProt

F2I0U8 - F2I0U8_PELSM

Protein

Isocitrate dehydrogenase [NADP]

Gene

SAR11G3_00909

Organism
Pelagibacter sp. (strain IMCC9063)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADP
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi309 – 3146NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciCPEL1002672:GHAA-925-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:SAR11G3_00909Imported
    OrganismiPelagibacter sp. (strain IMCC9063)Imported
    Taxonomic identifieri1002672 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000009181: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF2I0U8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F2I0U8-1 [UniParc]FASTAAdd to Basket

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    MAKIKVKNPV VELDGDEMTR IIWEFIKNKL ILPYLDVELK YFDLGMESRD    50
    KTDDQITIDS ANEIKKYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR 100
    NILGGTIFRE PIIMKNVPRL VPGWTDPIVI GRHAYGDQYR ATDFKVPGKG 150
    KLTVKWTSED GNDTVEHDVF DFPGSGIAMT MYNLDESIKD FARSCMNYGL 200
    LRKWPVYLST KNTILKTYDG RFKDLFQEIF DNEFKDEFAK HKLTYEHRLI 250
    DDMVACAMKW SGGYVWACKN YDGDVQCDTV AQGYGSLGLM TSVLMTPDGK 300
    TVESEAAHGT VTRHYREHQK GNETSTNPVA SIFAWTRGLA HRGKLDGNQE 350
    LIDFAHALEQ TCVETVETGE MTKDLAVLVG GEQKFLTTSQ FLEAINKNLQ 400
    SKLN 404
    Length:404
    Mass (Da):45,793
    Last modified:May 31, 2011 - v1
    Checksum:i18C44D8B65A72FF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002511 Genomic DNA. Translation: AEA81383.1.
    RefSeqiWP_013695548.1. NC_015380.1.
    YP_004358122.1. NC_015380.1.

    Genome annotation databases

    EnsemblBacteriaiAEA81383; AEA81383; SAR11G3_00909.
    GeneIDi10475911.
    KEGGipel:SAR11G3_00909.
    PATRICi54521386. VBICanPel201843_0897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002511 Genomic DNA. Translation: AEA81383.1 .
    RefSeqi WP_013695548.1. NC_015380.1.
    YP_004358122.1. NC_015380.1.

    3D structure databases

    ProteinModelPortali F2I0U8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEA81383 ; AEA81383 ; SAR11G3_00909 .
    GeneIDi 10475911.
    KEGGi pel:SAR11G3_00909.
    PATRICi 54521386. VBICanPel201843_0897.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci CPEL1002672:GHAA-925-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of strain IMCC9063, belonging to SAR11 subgroup 3, isolated from the Arctic Ocean."
      Oh H.M., Kang I., Lee K., Jang Y., Lim S.I., Cho J.C.
      J. Bacteriol. 193:3379-3380(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IMCC9063Imported.

    Entry informationi

    Entry nameiF2I0U8_PELSM
    AccessioniPrimary (citable) accession number: F2I0U8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3