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Protein

Isocitrate dehydrogenase [NADP]

Gene

SAR11G3_00909

Organism
Pelagibacter sp. (strain IMCC9063)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Binding sitei259 – 2591NADPUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi309 – 3146NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCPEL1002672:GHAA-925-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:SAR11G3_00909Imported
OrganismiPelagibacter sp. (strain IMCC9063)Imported
Taxonomic identifieri1002672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000009181 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF2I0U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiDVMSDMI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

F2I0U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKVKNPV VELDGDEMTR IIWEFIKNKL ILPYLDVELK YFDLGMESRD
60 70 80 90 100
KTDDQITIDS ANEIKKYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR
110 120 130 140 150
NILGGTIFRE PIIMKNVPRL VPGWTDPIVI GRHAYGDQYR ATDFKVPGKG
160 170 180 190 200
KLTVKWTSED GNDTVEHDVF DFPGSGIAMT MYNLDESIKD FARSCMNYGL
210 220 230 240 250
LRKWPVYLST KNTILKTYDG RFKDLFQEIF DNEFKDEFAK HKLTYEHRLI
260 270 280 290 300
DDMVACAMKW SGGYVWACKN YDGDVQCDTV AQGYGSLGLM TSVLMTPDGK
310 320 330 340 350
TVESEAAHGT VTRHYREHQK GNETSTNPVA SIFAWTRGLA HRGKLDGNQE
360 370 380 390 400
LIDFAHALEQ TCVETVETGE MTKDLAVLVG GEQKFLTTSQ FLEAINKNLQ

SKLN
Length:404
Mass (Da):45,793
Last modified:May 30, 2011 - v1
Checksum:i18C44D8B65A72FF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002511 Genomic DNA. Translation: AEA81383.1.
RefSeqiWP_013695548.1. NC_015380.1.
YP_004358122.1. NC_015380.1.

Genome annotation databases

EnsemblBacteriaiAEA81383; AEA81383; SAR11G3_00909.
KEGGipel:SAR11G3_00909.
PATRICi54521386. VBICanPel201843_0897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002511 Genomic DNA. Translation: AEA81383.1.
RefSeqiWP_013695548.1. NC_015380.1.
YP_004358122.1. NC_015380.1.

3D structure databases

ProteinModelPortaliF2I0U8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA81383; AEA81383; SAR11G3_00909.
KEGGipel:SAR11G3_00909.
PATRICi54521386. VBICanPel201843_0897.

Phylogenomic databases

KOiK00031.
OMAiDVMSDMI.

Enzyme and pathway databases

BioCyciCPEL1002672:GHAA-925-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of strain IMCC9063, belonging to SAR11 subgroup 3, isolated from the Arctic Ocean."
    Oh H.M., Kang I., Lee K., Jang Y., Lim S.I., Cho J.C.
    J. Bacteriol. 193:3379-3380(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMCC9063Imported.

Entry informationi

Entry nameiF2I0U8_PELSM
AccessioniPrimary (citable) accession number: F2I0U8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2011
Last sequence update: May 30, 2011
Last modified: March 31, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.