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F2HQ08

- F2HQ08_LACLV

UniProt

F2HQ08 - F2HQ08_LACLV

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Protein
D-alanine--D-alanine ligase
Gene
ddl, CVCAS_0326
Organism
Lactococcus lactis subsp. lactis (strain CV56)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi289 – 2891Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi302 – 3021Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi302 – 3021Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi304 – 3041Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 21756ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC929102:GLFG-342-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:CVCAS_0326Imported
OrganismiLactococcus lactis subsp. lactis (strain CV56)Imported
Taxonomic identifieri929102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000008128: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiF2HQ08.

Structurei

3D structure databases

ProteinModelPortaliF2HQ08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 335204ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.
OMAiQIDVIFP.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2HQ08-1 [UniParc]FASTAAdd to Basket

« Hide

MSKETLILLY GGRSAEREVS VLSAESVMRA VNYSRFVVKT YFITKGGEFI    50
KTQEFTDKPA EEEKLLTNDL AESYPKISPA AIYEKAAVVF PVLHGPMGED 100
GSIQGFLEIL RLAYVGPNIL SASSTMDKLL AKHVFEAVGV PQVPYVAAFA 150
DENQGEIAQE VVEKLEFPVF VKPANMGSSV GISKVDDLAD LQPALSEAYK 200
YDNRVVIEQG VDAREIECAV LGNNSDVSAT LPGEVVKDVE FYDYNSKYID 250
NKIQMDIPAK VPADLAQKMQ EYAIKAYKAV NGTGLSRCDF FVTKDGNVYL 300
NEINAIPGFT QWSMYPLLWE NMGLSYSDLI EKLVDLAKET FETRENHLL 349
Length:349
Mass (Da):38,693
Last modified:May 31, 2011 - v1
Checksum:i8E86996E1D2A8197
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002365 Genomic DNA. Translation: ADZ62991.1.
RefSeqiYP_005867725.1. NC_017486.1.

Genome annotation databases

EnsemblBacteriaiADZ62991; ADZ62991; CVCAS_0326.
GeneIDi12476405.
KEGGillt:CVCAS_0326.
PATRICi47137935. VBILacLac178659_0339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002365 Genomic DNA. Translation: ADZ62991.1 .
RefSeqi YP_005867725.1. NC_017486.1.

3D structure databases

ProteinModelPortali F2HQ08.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F2HQ08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ62991 ; ADZ62991 ; CVCAS_0326 .
GeneIDi 12476405.
KEGGi llt:CVCAS_0326.
PATRICi 47137935. VBILacLac178659_0339.

Phylogenomic databases

KOi K01921.
OMAi QIDVIFP.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LLAC929102:GLFG-342-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactococcus lactis subsp. lactis CV56, a probiotic strain isolated from the vaginas of healthy women."
    Gao Y., Lu Y., Teng K.L., Chen M.L., Zheng H.J., Zhu Y.Q., Zhong J.
    J. Bacteriol. 193:2886-2887(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CV56Imported.

Entry informationi

Entry nameiF2HQ08_LACLV
AccessioniPrimary (citable) accession number: F2HQ08
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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