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F2HIZ5

- F2HIZ5_LACLV

UniProt

F2HIZ5 - F2HIZ5_LACLV

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Protein
Thymidine kinase
Gene
yfiG, tdk, CVCAS_0503
Organism
Lactococcus lactis subsp. lactis (strain CV56)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLLAC929102:GLFG-539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:yfiGImported
Synonyms:tdkUniRule annotation
Ordered Locus Names:CVCAS_0503Imported
OrganismiLactococcus lactis subsp. lactis (strain CV56)Imported
Taxonomic identifieri929102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000008128: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliF2HIZ5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2HIZ5-1 [UniParc]FASTAAdd to Basket

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MAQLYFKYGT MNSGKSIEIL KVAHNYEEQG KPVLLMTSSL DTRAGVGTVA    50
SRIGMKAEAV AIDEEMSVFD YVNSLPAKPF CVLIDEAQFL NKKHVYDFAR 100
VVDELNVPVM AFGLKNDFRN ELFEGSKYLL LLADKIEEIK TICWYCSKKA 150
TMVIRTIDGK PVYEGEQLQI GGNETYIPVC RKHYFKPEI 189
Length:189
Mass (Da):21,423
Last modified:May 31, 2011 - v1
Checksum:iCF50B257CBA9B014
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002365 Genomic DNA. Translation: ADZ63165.1.
RefSeqiYP_005867899.1. NC_017486.1.

Genome annotation databases

EnsemblBacteriaiADZ63165; ADZ63165; CVCAS_0503.
GeneIDi12476602.
KEGGillt:CVCAS_0503.
PATRICi47138343. VBILacLac178659_0519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002365 Genomic DNA. Translation: ADZ63165.1 .
RefSeqi YP_005867899.1. NC_017486.1.

3D structure databases

ProteinModelPortali F2HIZ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ63165 ; ADZ63165 ; CVCAS_0503 .
GeneIDi 12476602.
KEGGi llt:CVCAS_0503.
PATRICi 47138343. VBILacLac178659_0519.

Phylogenomic databases

KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci LLAC929102:GLFG-539-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactococcus lactis subsp. lactis CV56, a probiotic strain isolated from the vaginas of healthy women."
    Gao Y., Lu Y., Teng K.L., Chen M.L., Zheng H.J., Zhu Y.Q., Zhong J.
    J. Bacteriol. 193:2886-2887(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CV56Imported.

Entry informationi

Entry nameiF2HIZ5_LACLV
AccessioniPrimary (citable) accession number: F2HIZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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