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F2GVG6

- F2GVG6_BRUM5

UniProt

F2GVG6 - F2GVG6_BRUM5

Protein

Isocitrate dehydrogenase [NADP]

Gene

BM590_A1197

Organism
Brucella melitensis (strain M5-90)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADP
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi308 – 3136NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBMEL703352:GL9P-1217-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:BM590_A1197Imported
    OrganismiBrucella melitensis (strain M5-90)Imported
    Taxonomic identifieri703352 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000008318: Chromosome I

    Structurei

    3D structure databases

    ProteinModelPortaliF2GVG6.
    SMRiF2GVG6. Positions 3-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2GVG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD    50
    ATNDQVTIDA ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR 100
    NILGGVIFRE PIICKNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG 150
    TLTIKFVGED GQTIEHEVYQ APSAGVAMAM YNLDESIREF ARASFNYGLQ 200
    RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK KIWYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 300
    VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL 350
    KKFAETLEKV CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK 400
    AMAA 404
    Length:404
    Mass (Da):45,455
    Last modified:May 31, 2011 - v1
    Checksum:i453241CC1A59DC48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001851 Genomic DNA. Translation: ADZ87141.1.
    RefSeqiYP_005600645.1. NC_017246.1.

    Genome annotation databases

    EnsemblBacteriaiADZ87141; ADZ87141; BM590_A1197.
    GeneIDi12152728.
    KEGGibmg:BM590_A1197.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001851 Genomic DNA. Translation: ADZ87141.1 .
    RefSeqi YP_005600645.1. NC_017246.1.

    3D structure databases

    ProteinModelPortali F2GVG6.
    SMRi F2GVG6. Positions 3-403.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADZ87141 ; ADZ87141 ; BM590_A1197 .
    GeneIDi 12152728.
    KEGGi bmg:BM590_A1197.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci BMEL703352:GL9P-1217-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequences of Brucella melitensis strains M28 and M5-90, with different virulence backgrounds."
      Wang F., Hu S., Gao Y., Qiao Z., Liu W., Bu Z.
      J. Bacteriol. 193:2904-2905(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M5-90Imported.

    Entry informationi

    Entry nameiF2GVG6_BRUM5
    AccessioniPrimary (citable) accession number: F2GVG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3