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F2GVG6 (F2GVG6_BRUM5) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:BM590_A1197 EMBL ADZ87141.1
OrganismBrucella melitensis (strain M5-90) [Complete proteome] [HAMAP] EMBL ADZ87141.1
Taxonomic identifier703352 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
F2GVG6 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 453241CC1A59DC48

FASTA40445,455
        10         20         30         40         50         60 
MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD ATNDQVTIDA 

        70         80         90        100        110        120 
ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG TLTIKFVGED GQTIEHEVYQ APSAGVAMAM 

       190        200        210        220        230        240 
YNLDESIREF ARASFNYGLQ RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK 

       250        260        270        280        290        300 
KIWYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL KKFAETLEKV 

       370        380        390        400 
CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK AMAA 

« Hide

References

[1]"Complete genome sequences of Brucella melitensis strains M28 and M5-90, with different virulence backgrounds."
Wang F., Hu S., Gao Y., Qiao Z., Liu W., Bu Z.
J. Bacteriol. 193:2904-2905(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M5-90 EMBL ADZ87141.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001851 Genomic DNA. Translation: ADZ87141.1.
RefSeqYP_005600645.1. NC_017246.1.

3D structure databases

ProteinModelPortalF2GVG6.
SMRF2GVG6. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADZ87141; ADZ87141; BM590_A1197.
GeneID12152728.
KEGGbmg:BM590_A1197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycBMEL703352:GL9P-1217-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2GVG6_BRUM5
AccessionPrimary (citable) accession number: F2GVG6
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 16, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)