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F2GE13 (F2GE13_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazole glycerol phosphate synthase subunit HisF HAMAP-Rule MF_01013
EC=4.1.3.- HAMAP-Rule MF_01013
Alternative name(s):
IGP synthase cyclase subunit HAMAP-Rule MF_01013
IGP synthase subunit HisF HAMAP-Rule MF_01013
ImGP synthase subunit HisF HAMAP-Rule MF_01013
Gene names
Name:hisF HAMAP-Rule MF_01013
ORF Names:TBSG_02401 EMBL AEB04530.1
OrganismMycobacterium tuberculosis KZN 4207 EMBL AEB04530.1
Taxonomic identifier478433 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Catalytic activity

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. HAMAP-Rule MF_01013 SAAS SAAS004651

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. HAMAP-Rule MF_01013 SAAS SAAS004651

Subunit structure

Heterodimer of HisH and HisF By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01013.

Sequence similarities

Belongs to the HisA/HisF family. RuleBase RU003657 HAMAP-Rule MF_01013

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site221 By similarity HAMAP-Rule MF_01013
Active site1411 By similarity HAMAP-Rule MF_01013

Sequences

Sequence LengthMass (Da)Tools
F2GE13 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 2DAF561C3398EBA5

FASTA26727,221
        10         20         30         40         50         60 
MYADRDLPGA GGLAVRVIPC LDVDDGRVVK GVNFENLRDA GDPVELAAVY DAEGADELTF 

        70         80         90        100        110        120 
LDVTASSSGR ATMLEVVRRT AEQVFIPLTV GGGVRTVADV DSLLRAGADK VAVNTAAIAC 

       130        140        150        160        170        180 
PDLLADMARQ FGSQCIVLSV DARTVPVGSA PTPSGWEVTT HGGRRGTGMD AVQWAARGAD 

       190        200        210        220        230        240 
LGVGEILLNS MDADGTKAGF DLALLRAVRA AVTVPVIASG GAGAVEHFAP AVAAGADAVL 

       250        260 
AASVFHFREL TIGQVKAALA AEGITVR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001662 Genomic DNA. Translation: AEB04530.1.
RefSeqYP_005100869.1. NC_016768.1.

3D structure databases

ProteinModelPortalF2GE13.
SMRF2GE13. Positions 13-267.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEB04530; AEB04530; TBSG_02401.
GeneID11693864.
KEGGmtk:TBSG_02401.

Phylogenomic databases

KOK02500.
OMARVVKGTN.

Enzyme and pathway databases

UniPathwayUPA00031; UER00010.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01013. HisF.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR004651. HisF.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00735. hisF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF2GE13_MYCTU
AccessionPrimary (citable) accession number: F2GE13
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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