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F2G7U6 (F2G7U6_ALTMD) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
EC=6.3.5.2 HAMAP-Rule MF_00344
Alternative name(s):
GMP synthetase HAMAP-Rule MF_00344
Glutamine amidotransferase HAMAP-Rule MF_00344
Gene names
Name:guaA HAMAP-Rule MF_00344 EMBL AEA98695.1
Synonyms:guaA3
Ordered Locus Names:MADE_1012805
OrganismAlteromonas macleodii (strain DSM 17117 / Deep ecotype) [Complete proteome] [HAMAP] EMBL AEA98695.1
Taxonomic identifier314275 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Alteromonas ›

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344 SAAS SAAS022955

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344 SAAS SAAS022955

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain9 – 207199Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00344
Domain208 – 400193GMPS ATP-PPase By similarity HAMAP-Rule MF_00344
Nucleotide binding235 – 2417ATP By similarity HAMAP-Rule MF_00344

Sites

Active site861Nucleophile By similarity HAMAP-Rule MF_00344
Active site1811 By similarity HAMAP-Rule MF_00344
Active site1831 By similarity HAMAP-Rule MF_00344

Sequences

Sequence LengthMass (Da)Tools
F2G7U6 [UniParc].

Last modified May 31, 2011. Version 1.
Checksum: 4B9AA7086820C714

FASTA52558,585
        10         20         30         40         50         60 
MTTNIHDQRI LILDFGSQYT QLIARRVREI GVYCELWAWD VTEEQIREFN PQGIILSGGP 

        70         80         90        100        110        120 
ESVTEEGSPR APDYVFEAGV PVLGVCYGMQ TMAHQLGGGV LGSDKREFGY AQVEVIKPSP 

       130        140        150        160        170        180 
LLDKIEDAIG DNGAALLDVW MSHGDKVAAI PEGFETIAQT ASCPHAAMYN EEKQFYGVQF 

       190        200        210        220        230        240 
HPEVTHTRQG MRLLTQFVMD ICKCEKLWTA GAIIEDAIER IKEKVGDERV ILGLSGGVDS 

       250        260        270        280        290        300 
SVTAMLLHRA IGKNLTCVFV DNGLLRLNEA DQVMEMFGDH FGLNINRVDA EGRFLDRLKG 

       310        320        330        340        350        360 
IEDPELKRKA IGNEFVRVFD EEASKLENAK WLAQGTIYPD VIESAGSATG KAHVIKSHHN 

       370        380        390        400        410        420 
VGGLPEDMEL GLVEPLRELF KDEVRKIGLE LGLPYDMLYR HPFPGPGLGV RVLGEIKKEY 

       430        440        450        460        470        480 
CDLLRRADAI FIEELYAADL YQKVSQAFTV FLPVRSVGVM GDARKYDWVV SLRAVETIDF 

       490        500        510        520 
MTAHWAHLPY DFLGKVSNRI INEIDGISRV VYDISGKPPA TIEWE

« Hide

References

[1]"Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
Ivars-Martinez E., Martin-Cuadrado A.B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17117 / Deep ecotype.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001103 Genomic DNA. Translation: AEA98695.1.
RefSeqYP_004427693.1. NC_011138.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA98695; AEA98695; MADE_1012805.
GeneID10557911.
KEGGamc:MADE_1012805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01951.

Enzyme and pathway databases

BioCycAMAC314275:GHA7-2591-MONOMER.
UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF2G7U6_ALTMD
AccessionPrimary (citable) accession number: F2G7U6
Entry history
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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