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Protein

Imidazole glycerol phosphate synthase subunit HisH

Gene

hisH

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.UniRule annotationSAAS annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI), Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86NucleophileUniRule annotation1
Active sitei191UniRule annotation1
Active sitei193UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00010

Protein family/group databases

MEROPSiC26.965

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisHUniRule annotation (EC:2.4.2.-UniRule annotation)
Alternative name(s):
IGP synthase glutamine amidotransferase subunitUniRule annotation
IGP synthase subunit HisHUniRule annotation
ImGP synthase subunit HisHUniRule annotation
Short name:
IGPS subunit HisHUniRule annotation
Gene namesi
Name:hisHUniRule annotation
Ordered Locus Names:MADE_1012315Imported
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)Imported
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF2G6W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 209Glutamine amidotransferase type-1InterPro annotationAdd BLAST199

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108UJE Bacteria
COG0118 LUCA
KOiK02501
OMAiWVYFVHS

Family and domain databases

CDDicd01748 GATase1_IGP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00278 HisH, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010139 Imidazole-glycPsynth_HisH
PANTHERiPTHR42701 PTHR42701, 1 hit
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PIRSFiPIRSF000495 Amidotransf_hisH, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR01855 IMP_synth_hisH, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

F2G6W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVNTSQRQ KIVIVNTGCA NISSVRFALE RLGVEVDVSD DVKVIKSADK
60 70 80 90 100
VFLPGVGTAA AAMASIKQKA LADTLQTLTQ PVLGVCLGMQ LMVETSAEGG
110 120 130 140 150
FQGTGNIDCL NLMPGHVARM ESKGVRLPHM GWNTVAHKEE SLFKGIPQDT
160 170 180 190 200
YFYFVHSFAV PEYEHTLASC TYGKTFSAAI NKNNFYGVQF HPERSGEAGA

QLLTNFVNL
Length:209
Mass (Da):22,604
Last modified:May 31, 2011 - v1
Checksum:i7A2399DCA03DF7A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA Translation: AEA98599.1
RefSeqiWP_012518917.1, NC_011138.3

Genome annotation databases

EnsemblBacteriaiAEA98599; AEA98599; MADE_1012315
KEGGiamc:MADE_1012315

Similar proteinsi

Entry informationi

Entry nameiF2G6W5_ALTMD
AccessioniPrimary (citable) accession number: F2G6W5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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