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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI), Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:2.4.2.17UniRule annotationSAAS annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotationImported
Ordered Locus Names:MADE_1012295Imported
OrganismiAlteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)Imported
Taxonomic identifieri1774373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
Proteomesi
  • UP000001870 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF2G6W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 215HisGInterPro annotationAdd BLAST162
Domaini224 – 297HisG_CInterPro annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
KOiK00765.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long. 1 hit.
InterProiView protein in InterPro
IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiView protein in Pfam
PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiView protein in PROSITE
PS01316. ATP_P_PHORIBOSYLTR. 1 hit.

Sequencei

Sequence statusi: Complete.

F2G6W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSNRLRIA VQKSGRLSDD SIALLKAIGI KLNIRDRLLI AHSTNQPIDL
60 70 80 90 100
LRVRDDDIPG LVMDGVVDLG FIGENELEEK MLERKAAGKP FEYEVLRRLD
110 120 130 140 150
YGGCRLSIAV PNEMDYDGIQ SLEGKKVATT YPYLLERYFK EQGINAKAVM
160 170 180 190 200
LQGSVEVAPR AGVADAICDL VSTGATLEAN GLVEKDVIFR SKAVLIKRAD
210 220 230 240 250
GELSDEKETL VNRLMPRVDG VLLAKESKYI MLHAPKAYLE QVKSLLPGAE
260 270 280 290 300
NPTVLPLAGN EEQVAIHVVS TETLFWETME KLKALGCSSI LVMPIEKMMG
Length:300
Mass (Da):33,067
Last modified:May 31, 2011 - v1
Checksum:iD0266FD8C5B48E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001103 Genomic DNA. Translation: AEA98595.1.
RefSeqiWP_012518913.1. NC_011138.3.

Genome annotation databases

EnsemblBacteriaiAEA98595; AEA98595; MADE_1012295.
KEGGiamc:MADE_1012295.

Similar proteinsi

Entry informationi

Entry nameiF2G6W1_ALTMD
AccessioniPrimary (citable) accession number: F2G6W1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: July 5, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported