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Protein

Nuclear export protein

Gene

NS2

Organism
Influenza A virus (A/chicken/Vietnam/G14/2008(H3N8))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.UniRule annotationSAAS annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interactionUniRule annotationSAAS annotation, TransportUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear export proteinUniRule annotation
Short name:
NEPUniRule annotation
Alternative name(s):
Non-structural protein 2UniRule annotation
Short name:
NS2UniRule annotation
Gene namesi
Name:NS2Imported
Synonyms:NSUniRule annotation
OrganismiInfluenza A virus (A/chicken/Vietnam/G14/2008(H3N8))Imported
Taxonomic identifieri908270 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Proteomesi
  • UP000123537 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Binds M1 protein. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.UniRule annotation
Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.UniRule annotationSAAS annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 26Nuclear export signalUniRule annotation10
Motifi90 – 99Nuclear export signalUniRule annotation10

Sequence similaritiesi

Belongs to the influenza viruses NEP family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_04067 INFV_NEP, 1 hit
InterProiView protein in InterPro
IPR000968 Flu_NS2
PfamiView protein in Pfam
PF00601 Flu_NS2, 1 hit

Sequencei

Sequence statusi: Complete.

F1T0S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSNTVSSFQ YLLFQDILMR MSKMQLGSSS EDLNGMITQF ESLKLYRDSL
60 70 80 90 100
GEAVMRMGDL HSLQSRNGKW REQLSQKFEE IRWLIEEVRH RLKITENSFE
110 120
QITFMQALQL LLEVEQEIRT FSFQLI
Length:126
Mass (Da):15,003
Last modified:May 31, 2011 - v1
Checksum:i0D4DBA18760AE699
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593459 Viral cRNA Translation: BAK18421.1

Entry informationi

Entry nameiF1T0S4_9INFA
AccessioniPrimary (citable) accession number: F1T0S4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 25, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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