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Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiF1T0F8.

Expressioni

Gene expression databases

BgeeiF1T0F8.
ExpressionAtlasiF1T0F8. baseline and differential.
GenevisibleiF1T0F8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368401.

Structurei

3D structure databases

ProteinModelPortaliF1T0F8.
SMRiF1T0F8. Positions 4-150, 225-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation

Keywords - Domaini

HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotation

Phylogenomic databases

KOiK08031.
OMAiQATWESG.
PhylomeDBiF1T0F8.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1T0F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA
60 70 80 90 100
DAKVQVLDNQ NVSNGCVSKI LGRYYETGSI RPRAIGGSKP RVATPEVVSK
110 120 130 140 150
IAQYKRECPS IFAWEIRDRL LSEGVCTNDN IPSVSSINRV LRNLASEKQQ
160 170 180 190 200
MGADGMYDKL RMLNGQTGSW GTRPGWYPGT SVPGQPTQDG CQQQEGGGEN
210 220 230 240 250
TNSISSNGED SDEAQMRLQL KRKLQRNRTS FTQEQIEALE KEFERTHYPD
260 270 280 290 300
VFARERLAAK IDLPEARIQV WFSNRRAKWR REEKLRNQRR QASNTPSHIP
310 320 330 340 350
ISSSFSTSVY QPIPQPTTPV SSFTSGSMLG RTDTALTNTY SALPPMPSFT
360 370 380 390 400
MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM
410 420 430
GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ
Length:436
Mass (Da):48,218
Last modified:May 31, 2011 - v1
Checksum:i74926827347A20B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593092 mRNA. Translation: BAJ84032.1.
AB593093 mRNA. Translation: BAJ84033.1.
AB593094 mRNA. Translation: BAJ84034.1.
RefSeqiNP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.3.
UniGeneiHs.270303.
Hs.611376.

Genome annotation databases

GeneIDi5080.
KEGGihsa:5080.
UCSCiuc001mtg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593092 mRNA. Translation: BAJ84032.1.
AB593093 mRNA. Translation: BAJ84033.1.
AB593094 mRNA. Translation: BAJ84034.1.
RefSeqiNP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.3.
UniGeneiHs.270303.
Hs.611376.

3D structure databases

ProteinModelPortaliF1T0F8.
SMRiF1T0F8. Positions 4-150, 225-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368401.

Proteomic databases

PRIDEiF1T0F8.

Protocols and materials databases

DNASUi5080.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5080.
KEGGihsa:5080.
UCSCiuc001mtg.5. human.

Organism-specific databases

CTDi5080.

Phylogenomic databases

KOiK08031.
OMAiQATWESG.
PhylomeDBiF1T0F8.

Miscellaneous databases

ChiTaRSiPAX6. human.
GenomeRNAii5080.
NextBioi19596.

Gene expression databases

BgeeiF1T0F8.
ExpressionAtlasiF1T0F8. baseline and differential.
GenevisibleiF1T0F8. HS.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1T0F8_HUMAN
AccessioniPrimary (citable) accession number: F1T0F8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.