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F1T0F8

- F1T0F8_HUMAN

UniProt

F1T0F8 - F1T0F8_HUMAN

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Protein
Submitted name: Paired box protein Pax-6
Gene
PAX6
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. double-stranded DNA binding Source: Ensembl
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. axon guidance Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. cerebral cortex regionalization Source: Ensembl
  5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
  6. dorsal/ventral axis specification Source: Ensembl
  7. embryonic camera-type eye morphogenesis Source: Ensembl
  8. eye photoreceptor cell development Source: Ensembl
  9. forebrain anterior/posterior pattern specification Source: Ensembl
  10. forebrain dorsal/ventral pattern formation Source: Ensembl
  11. forebrain-midbrain boundary formation Source: Ensembl
  12. hindbrain development Source: Ensembl
  13. keratinocyte differentiation Source: Ensembl
  14. lacrimal gland development Source: Ensembl
  15. lens development in camera-type eye Source: Ensembl
  16. negative regulation of epithelial cell proliferation Source: Ensembl
  17. negative regulation of neuron differentiation Source: Ensembl
  18. neuron migration Source: Ensembl
  19. oligodendrocyte cell fate specification Source: Ensembl
  20. pancreatic A cell development Source: Ensembl
  21. pituitary gland development Source: Ensembl
  22. positive regulation of cell fate specification Source: Ensembl
  23. positive regulation of epithelial cell differentiation Source: Ensembl
  24. positive regulation of neuroblast proliferation Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. protein localization to organelle Source: Ensembl
  27. regulation of cell migration Source: Ensembl
  28. regulation of timing of cell differentiation Source: Ensembl
  29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
  30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
  31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
  32. salivary gland morphogenesis Source: Ensembl
  33. signal transduction involved in regulation of gene expression Source: Ensembl
  34. smoothened signaling pathway Source: Ensembl
  35. type B pancreatic cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotations

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation
Contains paired domain.SAAS annotations

Keywords - Domaini

HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotations

Phylogenomic databases

KOiK08031.
OMAiAGENTNS.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1T0F8-1 [UniParc]FASTAAdd to Basket

« Hide

MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA    50
DAKVQVLDNQ NVSNGCVSKI LGRYYETGSI RPRAIGGSKP RVATPEVVSK 100
IAQYKRECPS IFAWEIRDRL LSEGVCTNDN IPSVSSINRV LRNLASEKQQ 150
MGADGMYDKL RMLNGQTGSW GTRPGWYPGT SVPGQPTQDG CQQQEGGGEN 200
TNSISSNGED SDEAQMRLQL KRKLQRNRTS FTQEQIEALE KEFERTHYPD 250
VFARERLAAK IDLPEARIQV WFSNRRAKWR REEKLRNQRR QASNTPSHIP 300
ISSSFSTSVY QPIPQPTTPV SSFTSGSMLG RTDTALTNTY SALPPMPSFT 350
MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM 400
GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ 436
Length:436
Mass (Da):48,218
Last modified:May 31, 2011 - v1
Checksum:i74926827347A20B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB593092 mRNA. Translation: BAJ84032.1.
AB593093 mRNA. Translation: BAJ84033.1.
AB593094 mRNA. Translation: BAJ84034.1.
RefSeqiNP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.2.
UniGeneiHs.270303.
Hs.611376.

Genome annotation databases

GeneIDi5080.
KEGGihsa:5080.
UCSCiuc001mtg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB593092 mRNA. Translation: BAJ84032.1 .
AB593093 mRNA. Translation: BAJ84033.1 .
AB593094 mRNA. Translation: BAJ84034.1 .
RefSeqi NP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.2.
UniGenei Hs.270303.
Hs.611376.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5080.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5080.
KEGGi hsa:5080.
UCSCi uc001mtg.5. human.

Organism-specific databases

CTDi 5080.

Phylogenomic databases

KOi K08031.
OMAi AGENTNS.

Miscellaneous databases

GenomeRNAii 5080.
NextBioi 19596.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1T0F8_HUMAN
AccessioniPrimary (citable) accession number: F1T0F8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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