Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F1T0F8

- F1T0F8_HUMAN

UniProt

F1T0F8 - F1T0F8_HUMAN

Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. cerebral cortex regionalization Source: Ensembl
    5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. embryonic camera-type eye morphogenesis Source: Ensembl
    8. eye photoreceptor cell development Source: Ensembl
    9. forebrain anterior/posterior pattern specification Source: Ensembl
    10. forebrain dorsal/ventral pattern formation Source: Ensembl
    11. forebrain-midbrain boundary formation Source: Ensembl
    12. hindbrain development Source: Ensembl
    13. keratinocyte differentiation Source: Ensembl
    14. lacrimal gland development Source: Ensembl
    15. lens development in camera-type eye Source: Ensembl
    16. negative regulation of epithelial cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron migration Source: Ensembl
    19. oligodendrocyte cell fate specification Source: Ensembl
    20. pancreatic A cell development Source: Ensembl
    21. pituitary gland development Source: Ensembl
    22. positive regulation of cell fate specification Source: Ensembl
    23. positive regulation of epithelial cell differentiation Source: Ensembl
    24. positive regulation of neuroblast proliferation Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein localization to organelle Source: Ensembl
    27. regulation of cell migration Source: Ensembl
    28. regulation of timing of cell differentiation Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
    30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
    31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
    32. salivary gland morphogenesis Source: Ensembl
    33. signal transduction involved in regulation of gene expression Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. type B pancreatic cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Paired box protein Pax-6Imported
    Gene namesi
    Name:PAX6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    SMRiF1T0F8. Positions 4-150, 225-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 paired domain.UniRule annotation
    Contains paired domain.SAAS annotation

    Keywords - Domaini

    HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK08031.
    OMAiAGENTNS.
    PhylomeDBiF1T0F8.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1T0F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA    50
    DAKVQVLDNQ NVSNGCVSKI LGRYYETGSI RPRAIGGSKP RVATPEVVSK 100
    IAQYKRECPS IFAWEIRDRL LSEGVCTNDN IPSVSSINRV LRNLASEKQQ 150
    MGADGMYDKL RMLNGQTGSW GTRPGWYPGT SVPGQPTQDG CQQQEGGGEN 200
    TNSISSNGED SDEAQMRLQL KRKLQRNRTS FTQEQIEALE KEFERTHYPD 250
    VFARERLAAK IDLPEARIQV WFSNRRAKWR REEKLRNQRR QASNTPSHIP 300
    ISSSFSTSVY QPIPQPTTPV SSFTSGSMLG RTDTALTNTY SALPPMPSFT 350
    MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM 400
    GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ 436
    Length:436
    Mass (Da):48,218
    Last modified:May 31, 2011 - v1
    Checksum:i74926827347A20B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB593092 mRNA. Translation: BAJ84032.1.
    AB593093 mRNA. Translation: BAJ84033.1.
    AB593094 mRNA. Translation: BAJ84034.1.
    RefSeqiNP_001245391.1. NM_001258462.1.
    NP_001245392.1. NM_001258463.1.
    NP_001595.2. NM_001604.5.
    XP_005253011.1. XM_005252954.2.
    UniGeneiHs.270303.
    Hs.611376.

    Genome annotation databases

    GeneIDi5080.
    KEGGihsa:5080.
    UCSCiuc001mtg.5. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB593092 mRNA. Translation: BAJ84032.1 .
    AB593093 mRNA. Translation: BAJ84033.1 .
    AB593094 mRNA. Translation: BAJ84034.1 .
    RefSeqi NP_001245391.1. NM_001258462.1.
    NP_001245392.1. NM_001258463.1.
    NP_001595.2. NM_001604.5.
    XP_005253011.1. XM_005252954.2.
    UniGenei Hs.270303.
    Hs.611376.

    3D structure databases

    SMRi F1T0F8. Positions 4-150, 225-292.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 5080.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5080.
    KEGGi hsa:5080.
    UCSCi uc001mtg.5. human.

    Organism-specific databases

    CTDi 5080.

    Phylogenomic databases

    KOi K08031.
    OMAi AGENTNS.
    PhylomeDBi F1T0F8.

    Miscellaneous databases

    GenomeRNAii 5080.
    NextBioi 19596.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
      Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
      Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiF1T0F8_HUMAN
    AccessioniPrimary (citable) accession number: F1T0F8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.