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F1T0F8

- F1T0F8_HUMAN

UniProt

F1T0F8 - F1T0F8_HUMAN

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Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. double-stranded DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. axon guidance Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. cerebral cortex regionalization Source: Ensembl
  5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
  6. dorsal/ventral axis specification Source: Ensembl
  7. embryonic camera-type eye morphogenesis Source: Ensembl
  8. eye photoreceptor cell development Source: Ensembl
  9. forebrain anterior/posterior pattern specification Source: Ensembl
  10. forebrain dorsal/ventral pattern formation Source: Ensembl
  11. forebrain-midbrain boundary formation Source: Ensembl
  12. hindbrain development Source: Ensembl
  13. keratinocyte differentiation Source: Ensembl
  14. lacrimal gland development Source: Ensembl
  15. lens development in camera-type eye Source: Ensembl
  16. negative regulation of epithelial cell proliferation Source: Ensembl
  17. negative regulation of neuron differentiation Source: Ensembl
  18. neuron migration Source: Ensembl
  19. oligodendrocyte cell fate specification Source: Ensembl
  20. pancreatic A cell development Source: Ensembl
  21. pituitary gland development Source: Ensembl
  22. positive regulation of cell fate specification Source: Ensembl
  23. positive regulation of epithelial cell differentiation Source: Ensembl
  24. positive regulation of neuroblast proliferation Source: Ensembl
  25. protein localization to organelle Source: Ensembl
  26. regulation of cell migration Source: Ensembl
  27. regulation of timing of cell differentiation Source: Ensembl
  28. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
  29. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
  30. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
  31. retina development in camera-type eye Source: Ensembl
  32. salivary gland morphogenesis Source: Ensembl
  33. signal transduction involved in regulation of gene expression Source: Ensembl
  34. smoothened signaling pathway Source: Ensembl
  35. type B pancreatic cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiF1T0F8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF1T0F8.
SMRiF1T0F8. Positions 4-150, 225-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation
Contains paired domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotation

Phylogenomic databases

KOiK08031.
OMAiAGENTNS.
PhylomeDBiF1T0F8.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1T0F8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA
60 70 80 90 100
DAKVQVLDNQ NVSNGCVSKI LGRYYETGSI RPRAIGGSKP RVATPEVVSK
110 120 130 140 150
IAQYKRECPS IFAWEIRDRL LSEGVCTNDN IPSVSSINRV LRNLASEKQQ
160 170 180 190 200
MGADGMYDKL RMLNGQTGSW GTRPGWYPGT SVPGQPTQDG CQQQEGGGEN
210 220 230 240 250
TNSISSNGED SDEAQMRLQL KRKLQRNRTS FTQEQIEALE KEFERTHYPD
260 270 280 290 300
VFARERLAAK IDLPEARIQV WFSNRRAKWR REEKLRNQRR QASNTPSHIP
310 320 330 340 350
ISSSFSTSVY QPIPQPTTPV SSFTSGSMLG RTDTALTNTY SALPPMPSFT
360 370 380 390 400
MANNLPMQPP VPSQTSSYSC MLPTSPSVNG RSYDTYTPPH MQTHMNSQPM
410 420 430
GTSGTTSTGL ISPGVSVPVQ VPGSEPDMSQ YWPRLQ
Length:436
Mass (Da):48,218
Last modified:May 31, 2011 - v1
Checksum:i74926827347A20B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB593092 mRNA. Translation: BAJ84032.1.
AB593093 mRNA. Translation: BAJ84033.1.
AB593094 mRNA. Translation: BAJ84034.1.
RefSeqiNP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.2.
UniGeneiHs.270303.
Hs.611376.

Genome annotation databases

GeneIDi5080.
KEGGihsa:5080.
UCSCiuc001mtg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB593092 mRNA. Translation: BAJ84032.1 .
AB593093 mRNA. Translation: BAJ84033.1 .
AB593094 mRNA. Translation: BAJ84034.1 .
RefSeqi NP_001245391.1. NM_001258462.1.
NP_001245392.1. NM_001258463.1.
NP_001595.2. NM_001604.5.
XP_005253011.1. XM_005252954.2.
UniGenei Hs.270303.
Hs.611376.

3D structure databases

ProteinModelPortali F1T0F8.
SMRi F1T0F8. Positions 4-150, 225-292.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5080.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5080.
KEGGi hsa:5080.
UCSCi uc001mtg.5. human.

Organism-specific databases

CTDi 5080.

Phylogenomic databases

KOi K08031.
OMAi AGENTNS.
PhylomeDBi F1T0F8.

Miscellaneous databases

GenomeRNAii 5080.
NextBioi 19596.

Gene expression databases

ExpressionAtlasi F1T0F8. baseline and differential.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1T0F8_HUMAN
AccessioniPrimary (citable) accession number: F1T0F8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.