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Protein
Submitted name:

Homeobox protein OTX2

Gene

OTX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi46 – 105HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein OTX2Imported
Submitted name:
Orthodenticle homolog 2 (Drosophila), isoform CRA_bImported
Gene namesi
Name:OTX2Imported
ORF Names:hCG_32530Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000165588.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000165588

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 104HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationImported

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
KOiK18490
OMAiSTADCLD
OrthoDBiEOG091G0K9K

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003022 Otx2_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01257 OTX2HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1T0D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPGPWASCPA ATPRKQRRER
60 70 80 90 100
TTFTRAQLDV LEALFAKTRY PDIFMREEVA LKINLPESRV QVWFKNRRAK
110 120 130 140 150
CRQQQQQQQN GGQNKVRPAK KKTSPAREVS SESGTSGQFT PPSSTSVPTI
160 170 180 190 200
ASSSAPVSIW SPASISPLSD PLSTSSSCMQ RSYPMTYTQA SGYSQGYAGS
210 220 230 240 250
TSYFGGMDCG SYLTPMHHQL PGPGATLSPM GTNAVTSHLN QSPASLSTQG
260 270 280 290
YGASSLGFNS TTDCLDYKDQ TASWKLNFNA DCLDYKDQTS SWKFQVL
Length:297
Mass (Da):32,406
Last modified:May 31, 2011 - v1
Checksum:iDB4A3AE99DDA6F6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593058 mRNA Translation: BAJ84005.1
CH471061 Genomic DNA Translation: EAW80693.1
RefSeqiNP_001257452.1, NM_001270523.1
NP_001257453.1, NM_001270524.1
NP_001257454.1, NM_001270525.1
NP_068374.1, NM_021728.3
UniGeneiHs.288655
Hs.741558

Genome annotation databases

GeneIDi5015
KEGGihsa:5015

Similar proteinsi

Entry informationi

Entry nameiF1T0D1_HUMAN
AccessioniPrimary (citable) accession number: F1T0D1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health