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F1T0D1

- F1T0D1_HUMAN

UniProt

F1T0D1 - F1T0D1_HUMAN

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Protein
Submitted name:

Homeobox protein OTX2

Gene

OTX2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell fate specification Source: Ensembl
  2. diencephalon morphogenesis Source: Ensembl
  3. dorsal/ventral pattern formation Source: Ensembl
  4. endoderm development Source: Ensembl
  5. eye photoreceptor cell fate commitment Source: Ensembl
  6. inner ear morphogenesis Source: Ensembl
  7. metencephalon development Source: Ensembl
  8. midbrain development Source: Ensembl
  9. neuron fate determination Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. primitive streak formation Source: Ensembl
  12. somite rostral/caudal axis specification Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein OTX2Imported
Submitted name:
Orthodenticle homolog 2 (Drosophila), isoform CRA_bImported
Gene namesi
Name:OTX2Imported
ORF Names:hCG_32530Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotationImported

Phylogenomic databases

KOiK18490.
OMAiNRRAKCH.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1T0D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPGPWASCPA ATPRKQRRER
60 70 80 90 100
TTFTRAQLDV LEALFAKTRY PDIFMREEVA LKINLPESRV QVWFKNRRAK
110 120 130 140 150
CRQQQQQQQN GGQNKVRPAK KKTSPAREVS SESGTSGQFT PPSSTSVPTI
160 170 180 190 200
ASSSAPVSIW SPASISPLSD PLSTSSSCMQ RSYPMTYTQA SGYSQGYAGS
210 220 230 240 250
TSYFGGMDCG SYLTPMHHQL PGPGATLSPM GTNAVTSHLN QSPASLSTQG
260 270 280 290
YGASSLGFNS TTDCLDYKDQ TASWKLNFNA DCLDYKDQTS SWKFQVL
Length:297
Mass (Da):32,406
Last modified:May 31, 2011 - v1
Checksum:iDB4A3AE99DDA6F6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593058 mRNA. Translation: BAJ84005.1.
CH471061 Genomic DNA. Translation: EAW80693.1.
RefSeqiNP_001257452.1. NM_001270523.1.
NP_001257453.1. NM_001270524.1.
NP_001257454.1. NM_001270525.1.
NP_068374.1. NM_021728.3.
UniGeneiHs.288655.
Hs.741558.

Genome annotation databases

GeneIDi5015.
KEGGihsa:5015.
UCSCiuc001xcq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB593058 mRNA. Translation: BAJ84005.1 .
CH471061 Genomic DNA. Translation: EAW80693.1 .
RefSeqi NP_001257452.1. NM_001270523.1.
NP_001257453.1. NM_001270524.1.
NP_001257454.1. NM_001270525.1.
NP_068374.1. NM_021728.3.
UniGenei Hs.288655.
Hs.741558.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5015.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5015.
KEGGi hsa:5015.
UCSCi uc001xcq.4. human.

Organism-specific databases

CTDi 5015.

Phylogenomic databases

KOi K18490.
OMAi NRRAKCH.

Miscellaneous databases

GenomeRNAii 5015.
NextBioi 19304.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view ]
PRINTSi PR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1T0D1_HUMAN
AccessioniPrimary (citable) accession number: F1T0D1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.