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F1SVL0

- F1SVL0_METKA

UniProt

F1SVL0 - F1SVL0_METKA

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Protein
Submitted name: Topoisomerase V
Gene
MK1436
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611ZincImported
Metal bindingi246 – 2461Zinc; via tele nitrogenImported

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Keywords - Ligandi

Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
Topoisomerase VImported
Gene namesi
Ordered Locus Names:MK1436Imported
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)Imported
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GFJX-ray2.91A1-685[»]
ProteinModelPortaliF1SVL0.
SMRiF1SVL0. Positions 3-519.

Miscellaneous databases

EvolutionaryTraceiF1SVL0.

Family & Domainsi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTiSM00278. HhH1. 11 hits.
[Graphical view]
SUPFAMiSSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.

Sequencei

Sequence statusi: Complete.

F1SVL0-1 [UniParc]FASTAAdd to Basket

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MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE    50
ELLELHQNFI LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP 100
ARYAIVYRRG WRAIAKALDI DEEDVPAIEV RAVKRNPLQP ALYRILVRYG 150
RVDLMPVTVD EVPPEMAGEF ERLIERYDVP IDEKEERILE ILRENPWTPH 200
DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE RTAKRHVKRR 250
DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK 300
LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN 350
RTLATLIDEH GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE 400
AYRAAVEIQL AELTKKEGVG RKTAERLLRA FGNPERVKQL AREFEIEKLA 450
SVEGVGERVL RSLVPGYASL ISIRGIDRER AERLLKKYGG YSKVREAGVE 500
ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS ASAVRRLPVE 550
ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY 600
DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA 650
SLNPEELAEK VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL 700
ERKVGEGRAR RLIEYFGSAG EVGKLVENAE VSKLLEVPGI GDEAVARLVP 750
GYKTLRDAGL TPAEAERVLK RYGSVSKVQE GATPDELREL GLGDAKIARI 800
LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL GLSDRKIARI 850
KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV 900
KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE 950
RVGPKLAERI RAAGKRYVEE RRSRRERIRR KLRG 984
Length:984
Mass (Da):112,207
Last modified:May 3, 2011 - v1
Checksum:i63ABCC55177571D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02649.1.
RefSeqiNP_614719.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM02649; AAM02649; MK1436.
GeneIDi1478031.
KEGGimka:MK1436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02649.1 .
RefSeqi NP_614719.1. NC_003551.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GFJ X-ray 2.91 A 1-685 [» ]
ProteinModelPortali F1SVL0.
SMRi F1SVL0. Positions 3-519.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM02649 ; AAM02649 ; MK1436 .
GeneIDi 1478031.
KEGGi mka:MK1436.

Miscellaneous databases

EvolutionaryTracei F1SVL0.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
SMARTi SM00278. HhH1. 11 hits.
[Graphical view ]
SUPFAMi SSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.
  2. "Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies."
    Rajan R., Prasad R., Taneja B., Wilson S.H., Mondragon A.
    Nucleic Acids Res. 41:657-666(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 1-685 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiF1SVL0_METKA
AccessioniPrimary (citable) accession number: F1SVL0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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