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F1SVL0

- F1SVL0_METKA

UniProt

F1SVL0 - F1SVL0_METKA

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Protein
Submitted name:

Topoisomerase V

Gene

MK1436

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611ZincImported
Metal bindingi246 – 2461Zinc; via tele nitrogenImported

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Keywords - Ligandi

Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
Topoisomerase VImported
Gene namesi
Ordered Locus Names:MK1436Imported
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)Imported
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GFJX-ray2.91A1-685[»]
ProteinModelPortaliF1SVL0.
SMRiF1SVL0. Positions 3-519.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiF1SVL0.

Family & Domainsi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTiSM00278. HhH1. 11 hits.
[Graphical view]
SUPFAMiSSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.

Sequencei

Sequence statusi: Complete.

F1SVL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE
60 70 80 90 100
ELLELHQNFI LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP
110 120 130 140 150
ARYAIVYRRG WRAIAKALDI DEEDVPAIEV RAVKRNPLQP ALYRILVRYG
160 170 180 190 200
RVDLMPVTVD EVPPEMAGEF ERLIERYDVP IDEKEERILE ILRENPWTPH
210 220 230 240 250
DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE RTAKRHVKRR
260 270 280 290 300
DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK
310 320 330 340 350
LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN
360 370 380 390 400
RTLATLIDEH GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE
410 420 430 440 450
AYRAAVEIQL AELTKKEGVG RKTAERLLRA FGNPERVKQL AREFEIEKLA
460 470 480 490 500
SVEGVGERVL RSLVPGYASL ISIRGIDRER AERLLKKYGG YSKVREAGVE
510 520 530 540 550
ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS ASAVRRLPVE
560 570 580 590 600
ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY
610 620 630 640 650
DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA
660 670 680 690 700
SLNPEELAEK VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL
710 720 730 740 750
ERKVGEGRAR RLIEYFGSAG EVGKLVENAE VSKLLEVPGI GDEAVARLVP
760 770 780 790 800
GYKTLRDAGL TPAEAERVLK RYGSVSKVQE GATPDELREL GLGDAKIARI
810 820 830 840 850
LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL GLSDRKIARI
860 870 880 890 900
KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV
910 920 930 940 950
KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE
960 970 980
RVGPKLAERI RAAGKRYVEE RRSRRERIRR KLRG
Length:984
Mass (Da):112,207
Last modified:May 3, 2011 - v1
Checksum:i63ABCC55177571D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02649.1.
RefSeqiNP_614719.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM02649; AAM02649; MK1436.
GeneIDi1478031.
KEGGimka:MK1436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02649.1 .
RefSeqi NP_614719.1. NC_003551.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GFJ X-ray 2.91 A 1-685 [» ]
ProteinModelPortali F1SVL0.
SMRi F1SVL0. Positions 3-519.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM02649 ; AAM02649 ; MK1436 .
GeneIDi 1478031.
KEGGi mka:MK1436.

Miscellaneous databases

EvolutionaryTracei F1SVL0.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR024065. TopoV_catalytic_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
SMARTi SM00278. HhH1. 11 hits.
[Graphical view ]
SUPFAMi SSF140979. SSF140979. 2 hits.
SSF47781. SSF47781. 6 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938Imported.
  2. "Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies."
    Rajan R., Prasad R., Taneja B., Wilson S.H., Mondragon A.
    Nucleic Acids Res. 41:657-666(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 1-685 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiF1SVL0_METKA
AccessioniPrimary (citable) accession number: F1SVL0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3