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F1SVL0

- F1SVL0_METKA

UniProt

F1SVL0 - F1SVL0_METKA

Protein
Submitted name:

Topoisomerase V

Gene

MK1436

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611ZincImported
    Metal bindingi246 – 2461Zinc; via tele nitrogenImported

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. isomerase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: InterPro

    Keywords - Molecular functioni

    IsomeraseImported

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Topoisomerase VImported
    Gene namesi
    Ordered Locus Names:MK1436Imported
    OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)Imported
    Taxonomic identifieri190192 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
    ProteomesiUP000001826: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GFJX-ray2.91A1-685[»]
    ProteinModelPortaliF1SVL0.
    SMRiF1SVL0. Positions 3-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiF1SVL0.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR024065. TopoV_catalytic_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    SMARTiSM00278. HhH1. 11 hits.
    [Graphical view]
    SUPFAMiSSF140979. SSF140979. 2 hits.
    SSF47781. SSF47781. 6 hits.

    Sequencei

    Sequence statusi: Complete.

    F1SVL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALVYDAEFV GSEREFEEER ETFLKGVKAY DGVLATRYLM ERSSSAKNDE    50
    ELLELHQNFI LLTGSYACSI DPTEDRYQNV IVRGVNFDER VQRLSTGGSP 100
    ARYAIVYRRG WRAIAKALDI DEEDVPAIEV RAVKRNPLQP ALYRILVRYG 150
    RVDLMPVTVD EVPPEMAGEF ERLIERYDVP IDEKEERILE ILRENPWTPH 200
    DEIARRLGLS VSEVEGEKDP ESSGIYSLWS RVVVNIEYDE RTAKRHVKRR 250
    DRLLEELYEH LEELSERYLR HPLTRRWIVE HKRDIMRRYL EQRIVECALK 300
    LQDRYGIRED VALCLARAFD GSISMIATTP YRTLKDVCPD LTLEEAKSVN 350
    RTLATLIDEH GLSPDAADEL IEHFESIAGI LATDLEEIER MYEEGRLSEE 400
    AYRAAVEIQL AELTKKEGVG RKTAERLLRA FGNPERVKQL AREFEIEKLA 450
    SVEGVGERVL RSLVPGYASL ISIRGIDRER AERLLKKYGG YSKVREAGVE 500
    ELREDGLTDA QIRELKGLKT LESIVGDLEK ADELKRKYGS ASAVRRLPVE 550
    ELRELGFSDD EIAEIKGIPK KLREAFDLET AAELYERYGS LKEIGRRLSY 600
    DDLLELGATP KAAAEIKGPE FKFLLNIEGV GPKLAERILE AVDYDLERLA 650
    SLNPEELAEK VEGLGEELAE RVVYAARERV ESRRKSGRQE RSEEEWKEWL 700
    ERKVGEGRAR RLIEYFGSAG EVGKLVENAE VSKLLEVPGI GDEAVARLVP 750
    GYKTLRDAGL TPAEAERVLK RYGSVSKVQE GATPDELREL GLGDAKIARI 800
    LGLRSLVNKR LDVDTAYELK RRYGSVSAVR KAPVKELREL GLSDRKIARI 850
    KGIPETMLQV RGMSVEKAER LLERFDTWTK VKEAPVSELV RVPGVGLSLV 900
    KEIKAQVDPA WKALLDVKGV SPELADRLVE ELGSPYRVLT AKKSDLMRVE 950
    RVGPKLAERI RAAGKRYVEE RRSRRERIRR KLRG 984
    Length:984
    Mass (Da):112,207
    Last modified:May 3, 2011 - v1
    Checksum:i63ABCC55177571D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM02649.1.
    RefSeqiNP_614719.1. NC_003551.1.

    Genome annotation databases

    EnsemblBacteriaiAAM02649; AAM02649; MK1436.
    GeneIDi1478031.
    KEGGimka:MK1436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM02649.1 .
    RefSeqi NP_614719.1. NC_003551.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GFJ X-ray 2.91 A 1-685 [» ]
    ProteinModelPortali F1SVL0.
    SMRi F1SVL0. Positions 3-519.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM02649 ; AAM02649 ; MK1436 .
    GeneIDi 1478031.
    KEGGi mka:MK1436.

    Miscellaneous databases

    EvolutionaryTracei F1SVL0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR010994. RuvA_2-like.
    IPR024065. TopoV_catalytic_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    SMARTi SM00278. HhH1. 11 hits.
    [Graphical view ]
    SUPFAMi SSF140979. SSF140979. 2 hits.
    SSF47781. SSF47781. 6 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938Imported.
    2. "Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies."
      Rajan R., Prasad R., Taneja B., Wilson S.H., Mondragon A.
      Nucleic Acids Res. 41:657-666(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 1-685 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiF1SVL0_METKA
    AccessioniPrimary (citable) accession number: F1SVL0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3