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F1SRY5

- UBP37_PIG

UniProt

F1SRY5 - UBP37_PIG

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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene
USP37
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-631 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521Nucleophile By similarity
Active sitei909 – 9091Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:USP37
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei631 – 6311Phosphoserine; by CDK2 By similarity
Modified residuei653 – 6531Phosphoserine By similarity
Modified residuei655 – 6551Phosphoserine By similarity

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination By similarity.
Phosphorylated at Ser-631 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-631 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with FZR1/CDH1 By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 954612USPAdd
BLAST
Repeati707 – 72620UIM 1Add
BLAST
Repeati809 – 82820UIM 2Add
BLAST
Repeati831 – 85020UIM 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 343KEN box 1 By similarity
Motifi71 – 799D-box 1 By similarity
Motifi96 – 10510D-box 2 By similarity
Motifi161 – 1699D-box 3 By similarity
Motifi224 – 2263KEN box 2 By similarity
Motifi785 – 7873KEN box 3 By similarity

Domaini

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination By similarity.

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00440000033542.
OMAiLQEFNNS.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1SRY5-1 [UniParc]FASTAAdd to Basket

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MSPLKIQGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI    50
FQLSHNIKNV VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD 100
AVHQNRLNAV AMKPSQGSGS FGAILGSRTS QKETHRQLSY SDNQVSSKRG 150
SLETKDDIPF RKVLGNPGRA SIKTAAGSGI TATRTIPSLT STSTPLRSGL 200
LENRTEKRKR MLSSGSELNE DYPKENDSSS NNKAMTDPSR KYLTSSREKQ 250
LSLKQSEENR TSGLLPLQSS SFYGSRAASK DYSPSSTNLD RTNISSQTPS 300
AKRSLGFLPQ PAPLSVKKLR CNQDYTGWNK PRLPLSSHQQ QLQGFSNLGN 350
TCYMNAILQS LFSLQSFAND LLKQGIPWKK IPLNALISRR FAHLLVKKDI 400
CNSETKKDLL KKVKNAISAT AERFSGYMQN DAHEFLSQCL DQLKEDMEKL 450
NKTWKTEPVP GEENSPDVTA TRVYTCPVIT NLEFEVQHSI ICKACGEIIP 500
KREQFNDLSI DLPRRKKPLP PRSIQDSLDL FFRAEELEYS CEKCGGKCAL 550
VRHKFNRLPR ILILHLKRYS FNVALSLNNK IGQQVIIPRY LTLSSHCTEN 600
TKPPFNLGWS AQMAISRPLK ASQMVNSCIT SPSTPSKNFT FKSKSSLALS 650
LDSDSEDELK RSVALSQRLC EISSSEQQQE DLEKDSKSCK LEPDKSELEN 700
SGFDAMSEEE LLAAVLEISK REASPSPSHE DDDKPTSSPD TGFAEDDIQE 750
MPENPDPMET EKPKTITEPD PASFTEITKD CDENKENKTP EGSQGEVDWL 800
QQYDMERERE EQELQQALAQ SLQEQEAWEQ KEDDDLKRAT ELSLQEFNNS 850
FLDSLGSDED SGNEDVLDME YTEAEAEELK RNAETGNLPH SYRLISVVSH 900
IGSTSSSGHY ISDVYDIKKQ AWFTYNDLEV SKIQEASVQS DRDRSGYIFF 950
YMHKEIFDEL LETEKNSQAL SMEVGKTTRQ AS 982
Length:982
Mass (Da):110,483
Last modified:May 3, 2011 - v1
Checksum:i3B09ABDE42E07AFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU570813 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSSSCT00000017635; ENSSSCP00000017157; ENSSSCG00000016194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU570813 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000017635 ; ENSSSCP00000017157 ; ENSSSCG00000016194 .

Phylogenomic databases

GeneTreei ENSGT00440000033542.
OMAi LQEFNNS.
OrthoDBi EOG7HMS09.
TreeFami TF323032.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 3 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Swine Genome Sequencing Consortium.
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Landrace.

Entry informationi

Entry nameiUBP37_PIG
AccessioniPrimary (citable) accession number: F1SRY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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