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F1SRY5

- UBP37_PIG

UniProt

F1SRY5 - UBP37_PIG

Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

USP37

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-631 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei352 – 3521NucleophilePROSITE-ProRule annotation
    Active sitei909 – 9091Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein K11-linked deubiquitination Source: UniProtKB
    4. protein K48-linked deubiquitination Source: UniProtKB
    5. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 37
    Ubiquitin thioesterase 37
    Ubiquitin-specific-processing protease 37
    Gene namesi
    Name:USP37
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 982982Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei631 – 6311Phosphoserine; by CDK2By similarity
    Modified residuei653 – 6531PhosphoserineBy similarity
    Modified residuei655 – 6551PhosphoserineBy similarity

    Post-translational modificationi

    Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination By similarity.By similarity
    Phosphorylated at Ser-631 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-631 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with FZR1/CDH1.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini343 – 954612USPAdd
    BLAST
    Repeati707 – 72620UIM 1Add
    BLAST
    Repeati809 – 82820UIM 2Add
    BLAST
    Repeati831 – 85020UIM 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi32 – 343KEN box 1By similarity
    Motifi71 – 799D-box 1By similarity
    Motifi96 – 10510D-box 2By similarity
    Motifi161 – 1699D-box 3By similarity
    Motifi224 – 2263KEN box 2By similarity
    Motifi785 – 7873KEN box 3By similarity

    Domaini

    The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.By similarity

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    GeneTreeiENSGT00440000033542.
    OMAiLQEFNNS.
    OrthoDBiEOG7HMS09.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view]
    SMARTiSM00726. UIM. 3 hits.
    [Graphical view]
    PROSITEiPS50330. UIM. 3 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1SRY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLKIQGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI    50
    FQLSHNIKNV VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD 100
    AVHQNRLNAV AMKPSQGSGS FGAILGSRTS QKETHRQLSY SDNQVSSKRG 150
    SLETKDDIPF RKVLGNPGRA SIKTAAGSGI TATRTIPSLT STSTPLRSGL 200
    LENRTEKRKR MLSSGSELNE DYPKENDSSS NNKAMTDPSR KYLTSSREKQ 250
    LSLKQSEENR TSGLLPLQSS SFYGSRAASK DYSPSSTNLD RTNISSQTPS 300
    AKRSLGFLPQ PAPLSVKKLR CNQDYTGWNK PRLPLSSHQQ QLQGFSNLGN 350
    TCYMNAILQS LFSLQSFAND LLKQGIPWKK IPLNALISRR FAHLLVKKDI 400
    CNSETKKDLL KKVKNAISAT AERFSGYMQN DAHEFLSQCL DQLKEDMEKL 450
    NKTWKTEPVP GEENSPDVTA TRVYTCPVIT NLEFEVQHSI ICKACGEIIP 500
    KREQFNDLSI DLPRRKKPLP PRSIQDSLDL FFRAEELEYS CEKCGGKCAL 550
    VRHKFNRLPR ILILHLKRYS FNVALSLNNK IGQQVIIPRY LTLSSHCTEN 600
    TKPPFNLGWS AQMAISRPLK ASQMVNSCIT SPSTPSKNFT FKSKSSLALS 650
    LDSDSEDELK RSVALSQRLC EISSSEQQQE DLEKDSKSCK LEPDKSELEN 700
    SGFDAMSEEE LLAAVLEISK REASPSPSHE DDDKPTSSPD TGFAEDDIQE 750
    MPENPDPMET EKPKTITEPD PASFTEITKD CDENKENKTP EGSQGEVDWL 800
    QQYDMERERE EQELQQALAQ SLQEQEAWEQ KEDDDLKRAT ELSLQEFNNS 850
    FLDSLGSDED SGNEDVLDME YTEAEAEELK RNAETGNLPH SYRLISVVSH 900
    IGSTSSSGHY ISDVYDIKKQ AWFTYNDLEV SKIQEASVQS DRDRSGYIFF 950
    YMHKEIFDEL LETEKNSQAL SMEVGKTTRQ AS 982
    Length:982
    Mass (Da):110,483
    Last modified:May 3, 2011 - v1
    Checksum:i3B09ABDE42E07AFF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU570813 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSSSCT00000017635; ENSSSCP00000017157; ENSSSCG00000016194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU570813 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000017635 ; ENSSSCP00000017157 ; ENSSSCG00000016194 .

    Phylogenomic databases

    GeneTreei ENSGT00440000033542.
    OMAi LQEFNNS.
    OrthoDBi EOG7HMS09.
    TreeFami TF323032.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view ]
    SMARTi SM00726. UIM. 3 hits.
    [Graphical view ]
    PROSITEi PS50330. UIM. 3 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Swine Genome Sequencing Consortium.
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Landrace.

    Entry informationi

    Entry nameiUBP37_PIG
    AccessioniPrimary (citable) accession number: F1SRY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3