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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

USP37

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei352NucleophilePROSITE-ProRule annotationBy similarity1
Active sitei909Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SSC-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:USP37
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004126461 – 982Ubiquitin carboxyl-terminal hydrolase 37Add BLAST982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei631Phosphoserine; by CDK2By similarity1
Modified residuei653PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination.By similarity
Phosphorylated at Ser-631 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-631 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiF1SRY5
PRIDEiF1SRY5

Expressioni

Gene expression databases

BgeeiENSSSCG00000016194
ExpressionAtlasiF1SRY5 baseline and differential

Interactioni

Subunit structurei

Interacts with FZR1/CDH1. Interacts with CDT1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017157

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 954USPAdd BLAST612
Domaini707 – 726UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini809 – 828UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini831 – 850UIM 3PROSITE-ProRule annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 34KEN box 1By similarity3
Motifi71 – 79D-box 1By similarity9
Motifi96 – 105D-box 2By similarity10
Motifi161 – 169D-box 3By similarity9
Motifi224 – 226KEN box 2By similarity3
Motifi785 – 787KEN box 3By similarity3

Domaini

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1868 Eukaryota
ENOG410XP8T LUCA
InParanoidiF1SRY5
OMAiWLQQYDM
OrthoDBiEOG091G01DZ
TreeFamiTF323032

Family and domain databases

CDDicd13312 PH_USP37_like, 1 hit
Gene3Di2.30.29.180, 1 hit
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR003903 UIM_dom
IPR032069 USP37-like_PH
IPR038093 USP37-like_PH_sf
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF16674 UCH_N, 1 hit
PF02809 UIM, 3 hits
SMARTiView protein in SMART
SM00726 UIM, 3 hits
PROSITEiView protein in PROSITE
PS50330 UIM, 3 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

F1SRY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLKIQGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI
60 70 80 90 100
FQLSHNIKNV VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD
110 120 130 140 150
AVHQNRLNAV AMKPSQGSGS FGAILGSRTS QKETHRQLSY SDNQVSSKRG
160 170 180 190 200
SLETKDDIPF RKVLGNPGRA SIKTAAGSGI TATRTIPSLT STSTPLRSGL
210 220 230 240 250
LENRTEKRKR MLSSGSELNE DYPKENDSSS NNKAMTDPSR KYLTSSREKQ
260 270 280 290 300
LSLKQSEENR TSGLLPLQSS SFYGSRAASK DYSPSSTNLD RTNISSQTPS
310 320 330 340 350
AKRSLGFLPQ PAPLSVKKLR CNQDYTGWNK PRLPLSSHQQ QLQGFSNLGN
360 370 380 390 400
TCYMNAILQS LFSLQSFAND LLKQGIPWKK IPLNALISRR FAHLLVKKDI
410 420 430 440 450
CNSETKKDLL KKVKNAISAT AERFSGYMQN DAHEFLSQCL DQLKEDMEKL
460 470 480 490 500
NKTWKTEPVP GEENSPDVTA TRVYTCPVIT NLEFEVQHSI ICKACGEIIP
510 520 530 540 550
KREQFNDLSI DLPRRKKPLP PRSIQDSLDL FFRAEELEYS CEKCGGKCAL
560 570 580 590 600
VRHKFNRLPR ILILHLKRYS FNVALSLNNK IGQQVIIPRY LTLSSHCTEN
610 620 630 640 650
TKPPFNLGWS AQMAISRPLK ASQMVNSCIT SPSTPSKNFT FKSKSSLALS
660 670 680 690 700
LDSDSEDELK RSVALSQRLC EISSSEQQQE DLEKDSKSCK LEPDKSELEN
710 720 730 740 750
SGFDAMSEEE LLAAVLEISK REASPSPSHE DDDKPTSSPD TGFAEDDIQE
760 770 780 790 800
MPENPDPMET EKPKTITEPD PASFTEITKD CDENKENKTP EGSQGEVDWL
810 820 830 840 850
QQYDMERERE EQELQQALAQ SLQEQEAWEQ KEDDDLKRAT ELSLQEFNNS
860 870 880 890 900
FLDSLGSDED SGNEDVLDME YTEAEAEELK RNAETGNLPH SYRLISVVSH
910 920 930 940 950
IGSTSSSGHY ISDVYDIKKQ AWFTYNDLEV SKIQEASVQS DRDRSGYIFF
960 970 980
YMHKEIFDEL LETEKNSQAL SMEVGKTTRQ AS
Length:982
Mass (Da):110,483
Last modified:May 3, 2011 - v1
Checksum:i3B09ABDE42E07AFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU570813 Genomic DNA No translation available.
UniGeneiSsc.22246

Similar proteinsi

Entry informationi

Entry nameiUBP37_PIG
AccessioniPrimary (citable) accession number: F1SRY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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