Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neuronal guanine nucleotide exchange factor

Gene

NGEF

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-193648 NRAGE signals death through JNK
R-SSC-194840 Rho GTPase cycle
R-SSC-3928663 EPHA-mediated growth cone collapse
R-SSC-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal guanine nucleotide exchange factorImported
Gene namesi
Name:NGEFImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

PTM / Processingi

Proteomic databases

PaxDbiF1SM48
PRIDEiF1SM48

Expressioni

Gene expression databases

BgeeiENSSSCG00000016295

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017263

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili284 – 304Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00550000074493
InParanoidiF1SM48
OrthoDBiEOG091G04NI
TreeFamiTF316357

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11939 SH3_ephexin1, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035635 Ephexin-1_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

F1SM48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLAAAFSA ACAVDHDSST SESDARDSAA GHLPGSESSS TPGNGATPEE
60 70 80 90 100
CPALADSPTT LTEALQMIHP IPADSWRNLI EQIGLLYQEY RDKSTLQEIE
110 120 130 140 150
TRRQQDAEIQ GNADRSPASE EAPEEDEEEE EEELPSPPER KALPQICLLS
160 170 180 190 200
NPHSRFNLWQ DLPEIRSSGV LDILQPEEIR LQEAMFELVT SEASYYKSLS
210 220 230 240 250
LLVSHFMENE RLKKLLHPSE AHILFSNVLD VMGVSERFLL ELERRMEENI
260 270 280 290 300
VISDVCDIVY RYAANHFSVY ITYVSNQTYQ ERTYKQLLQE KAAFRELIAQ
310 320 330 340 350
LELDPKCRGL PLSSFLILPF QRITRLKLLV QNILKRVEES SEREATALDA
360 370 380 390 400
HKELELVVKA CNEGVRKMSR TEQMISIQKK MEFKIKSVPI ISHSRWLLKQ
410 420 430 440 450
GELQQMSGPK TSRTLRTKKL FREIYLFLFN DLLVICRQIP GDKYQVFDSA
460 470 480 490 500
PRGLLRVEEL EDQGQTLANV FILRLLENAD DREATYMLKA TSQSEMKRWM
510 520 530 540 550
TSLAPNRRTK FVSFTSRLLD CPQVQCVHPY VAQQPDELTL ELADILNILD
560 570 580 590 600
KTEDGWIFGE RLHDQERGWF PSNMAEEILN PKIRSQNLKE CFRVHKMDDP
610
QRSQNKDRRK LGSRNRQ
Length:617
Mass (Da):71,012
Last modified:November 22, 2017 - v3
Checksum:iCB5CE2884E3F1DF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000101 Genomic DNA No translation available.
RefSeqiXP_005672344.1, XM_005672287.2

Genome annotation databases

EnsembliENSSSCT00000017744; ENSSSCP00000017263; ENSSSCG00000016295

Similar proteinsi

Entry informationi

Entry nameiF1SM48_PIG
AccessioniPrimary (citable) accession number: F1SM48
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: May 23, 2018
This is version 50 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health