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Protein
Submitted name:

Neuronal guanine nucleotide exchange factor

Gene

NGEF

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-193648. NRAGE signals death through JNK.
R-SSC-194840. Rho GTPase cycle.
R-SSC-3928663. EPHA-mediated growth cone collapse.
R-SSC-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal guanine nucleotide exchange factorImported
Gene namesi
Name:NGEFImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

PTM / Processingi

Proteomic databases

PaxDbiF1SM48.

Expressioni

Gene expression databases

BgeeiENSSSCG00000016295.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 364DHInterPro annotationAdd BLAST185
Domaini396 – 508PHInterPro annotationAdd BLAST113
Domaini519 – 580SH3InterPro annotationAdd BLAST62

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
InParanoidiF1SM48.
OMAiGWIFGER.
OrthoDBiEOG091G04NI.
TreeFamiTF316357.

Family and domain databases

CDDicd11939. SH3_ephexin1. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR035635. Ephexin-1_SH3.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

F1SM48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLAAAFSA ACAVDHDSST SESDARDSAA GHLPGSESSS TPGNGATPEE
60 70 80 90 100
CPALADSPTT LTEALQMIHP IPADSWRNLI EQIGLLYQEY RDKSTLQEIE
110 120 130 140 150
TRRQQDAEIQ GNADRSPASE EAPEEDEEEE EEELPSPPER KALPQICLLS
160 170 180 190 200
NPHSRFNLWQ DLPEIRSSGV LDILQPEEIR LQEAMFELVT SEASYYKSLS
210 220 230 240 250
LLVSHFMENE RLKKLLHPSE AHILFSNVLD VMGVSERFLL ELERRMEENI
260 270 280 290 300
VISDVCDIVY RYAANHFSVY ITYVSNQTYQ ERTYKQLLQE KAAFRELIAQ
310 320 330 340 350
LELDPKCRGL PLSSFLILPF QRITRLKLLV QNILKRVEES SEREATALDA
360 370 380 390 400
HKELELVVKA CNEGVRKMSR TEQMISIQKK MEFKIKSVPI ISHSRWLLKQ
410 420 430 440 450
GELQQMSGPK TSRTLRTKKL FREIYLFLFN DLLVICRQIP GDKYQVFDSA
460 470 480 490 500
PRGLLRVEEL EDQGQTLANV FILRLLENAD DREATYMLKA TSQSEMKRWM
510 520 530 540 550
TSLAPNRRTK FVSFTSRLLD CPQVQCVHPY VAQQPDELTL ELADILNILD
560 570 580 590 600
KTEDGWIFGE RLHDQERGWF PSNMAESNMA FEILNPKIRS QNLKECFRVH
610 620
KMDDPQRSQN KDRRKLGSRN RQ
Length:622
Mass (Da):71,562
Last modified:July 11, 2012 - v2
Checksum:iE00EDC733F51B7E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU571212 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSSSCT00000017744; ENSSSCP00000017263; ENSSSCG00000016295.

Similar proteinsi

Entry informationi

Entry nameiF1SM48_PIG
AccessioniPrimary (citable) accession number: F1SM48
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 11, 2012
Last modified: September 27, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported