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Protein

alpha-1,2-Mannosidase

Gene

MAN1A1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_213012. Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2.

Names & Taxonomyi

Protein namesi
Recommended name:
alpha-1,2-MannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:MAN1A1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016529.
KOiK01230.
OMAiAWEAVEX.
OrthoDBiEOG7X0VH1.
TreeFamiTF313420.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

F1SF40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVGGLLPLF SSPAGGGLGG GLGGGLGGGG GGGGRKGSGP SAFRLTEKFV
60 70 80 90 100
LLLVFSAFIT LCFGAIFFLP DSSKLLSGVL FHSSPALQPA ADHKPGPGAR
110 120 130 140 150
AEDAADGRAR PGEEGAPGDP AAALEDNLAR IRENHERALR EAKETLQKLP
160 170 180 190 200
EEIQRDILME KEKVAQDQMS NRMGFRLPPV YLVPLIGAID REPADAAVRE
210 220 230 240 250
KRAKIKEMMK HAWNNYKLYA WGKNELKPVS KGGHSSSLFG NIKGATIVDA
260 270 280 290 300
LDTLFIMKMK NEFEEAKAWV EEHLNFNVNA EVSVFEVNIR FIGGLISAYY
310 320 330 340 350
LSGEEIFRKK AVELGVKLLP AFYTPSGIPW ALLNIKSGIG RNWPWASGGS
360 370 380 390 400
SILAEFGTLH LEFIHLSYLS GNPFFAEKVM NIRKVLNNLE KPQGLYPNYL
410 420 430 440 450
NPNSGQWGQY HVSVGGLGDS FYEYLLKAWL MSDKTDLEAK KMYFDAIKAI
460 470 480 490 500
ETHLIRKSRN GLTYIAEWKG GLLEHKMGHL TCFAGGMFAL GADDAPDGLT
510 520 530 540 550
QHYLQLGAEI ARTCHESYSR TFVKLGPEAF RFDGGVEAIA TRQNEKYYIL
560 570 580 590 600
RPEVVETYLY MWRLTHDPKY RKWAWEAVEA LEKHCRVNGG YSGLRDVYVS
610 620 630 640 650
AQTYDDVQQS FFLAETLKYL YLIFSDDDLL PLEHWIFNTE AHPLPVLSRN

IKKVEDNEK
Length:659
Mass (Da):73,222
Last modified:May 3, 2011 - v1
Checksum:iE53614FEAAFE43A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468091 Genomic DNA. No translation available.
CU929640 Genomic DNA. No translation available.
RefSeqiXP_005659292.1. XM_005659235.1.
UniGeneiSsc.14512.

Genome annotation databases

EnsembliENSSSCT00000004691; ENSSSCP00000004583; ENSSSCG00000004244.
GeneIDi396919.
KEGGissc:396919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468091 Genomic DNA. No translation available.
CU929640 Genomic DNA. No translation available.
RefSeqiXP_005659292.1. XM_005659235.1.
UniGeneiSsc.14512.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000004691; ENSSSCP00000004583; ENSSSCG00000004244.
GeneIDi396919.
KEGGissc:396919.

Organism-specific databases

CTDi4121.

Phylogenomic databases

GeneTreeiENSGT00390000016529.
KOiK01230.
OMAiAWEAVEX.
OrthoDBiEOG7X0VH1.
TreeFamiTF313420.

Enzyme and pathway databases

ReactomeiREACT_213012. Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF1SF40_PIG
AccessioniPrimary (citable) accession number: F1SF40
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 7, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.