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Protein
Submitted name:

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-SSC-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-SSC-391160. Signal regulatory protein (SIRP) family interactions.
R-SSC-5683826. Surfactant metabolism.
R-SSC-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Submitted name:
Pulmonary surfactant-associated protein AImported
Gene namesi
Name:SFTPA1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500327201921 – 247Sequence analysisAdd BLAST227

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1SER2.

Expressioni

Gene expression databases

BgeeiENSSSCG00000010336.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011022.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 246C-type lectinInterPro annotationAdd BLAST93

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104102.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1SER2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI
60 70 80 90 100
KGDPGPPGPM GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQSA LHEIRHQILQ SMGVLSFQEF MLAVGEKVFS TNGQSVAFMS
160 170 180 190 200
LESCVPEQGR IAAPRSPEEN EAIASIVKKH NTYAYLGLVE GPTAGDFFYL
210 220 230 240
DGTPVNYTNW YPGEPRGRGK EKCVEMYTDG QWNDRNCQQY RLAICEF
Length:247
Mass (Da):26,417
Last modified:May 3, 2011 - v1
Checksum:i3E4A5ED2DD57F0AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469045 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSSSCT00000011315; ENSSSCP00000011023; ENSSSCG00000010336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469045 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011022.

Proteomic databases

PaxDbiF1SER2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000011315; ENSSSCP00000011023; ENSSSCG00000010336.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104102.

Enzyme and pathway databases

ReactomeiR-SSC-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-SSC-391160. Signal regulatory protein (SIRP) family interactions.
R-SSC-5683826. Surfactant metabolism.
R-SSC-5686938. Regulation of TLR by endogenous ligand.

Gene expression databases

BgeeiENSSSCG00000010336.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1SER2_PIG
AccessioniPrimary (citable) accession number: F1SER2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 30, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.