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F1S8E6 (F1S8E6_PIG) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyhypusine hydroxylase HAMAP-Rule MF_03101

Short name=DOHH HAMAP-Rule MF_03101
EC=1.14.99.29 HAMAP-Rule MF_03101
Alternative name(s):
Deoxyhypusine dioxygenase HAMAP-Rule MF_03101
Deoxyhypusine monooxygenase HAMAP-Rule MF_03101
Gene names
Name:DOHH HAMAP-Rule MF_03101 Ensembl ENSSSCP00000014326
OrganismSus scrofa (Pig) [Reference proteome] Ensembl ENSSSCP00000014326
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor By similarity. HAMAP-Rule MF_03101

Catalytic activity

[eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O. HAMAP-Rule MF_03101

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP-Rule MF_03101

Pathway

Protein modification; eIF5A hypusination. HAMAP-Rule MF_03101

Sequence similarities

Belongs to the deoxyhypusine hydroxylase family. HAMAP-Rule MF_03101

Contains 1 HEAT-like PBS-type repeat. HAMAP-Rule MF_03101

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSSSCP00000014326

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Repeat176 – 19924HEAT-like PBS-type By similarity HAMAP-Rule MF_03101

Sites

Metal binding561Iron 1 By similarity HAMAP-Rule MF_03101
Metal binding571Iron 1 By similarity HAMAP-Rule MF_03101
Metal binding891Iron 1 By similarity HAMAP-Rule MF_03101
Metal binding901Iron 1 By similarity HAMAP-Rule MF_03101
Metal binding2081Iron 2 By similarity HAMAP-Rule MF_03101
Metal binding2091Iron 2 By similarity HAMAP-Rule MF_03101
Metal binding2411Iron 2 By similarity HAMAP-Rule MF_03101
Metal binding2421Iron 2 By similarity HAMAP-Rule MF_03101

Sequences

Sequence LengthMass (Da)Tools
F1S8E6 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 5AF4AA0E1CB951D9

FASTA30333,037
        10         20         30         40         50         60 
MVTEQEVEAV GKMLVDPGQP LQARFRALFT LRGLGGPGAI TWISRAFGDD SALLKHELAY 

        70         80         90        100        110        120 
CLGQMQDSRA IPVLVDVLRD TCQEPMVRHE AGEALGAIGN PEVLEILKQY STDPVVEVAE 

       130        140        150        160        170        180 
TCQLAVRRLE WLQQHSGEPV AQGPYLSVDP APPAQERDVG QLREMLLDEA QPLFDRYRAM 

       190        200        210        220        230        240 
FALRDIGGEE AALALAEGLL CGSALFRHEI GYVLGQLQHE AAVPHLMAAL ARPAESPMVR 

       250        260        270        280        290        300 
HECAEALGAI ARPACLAALR AYAADPERVV RESCEVALDM YEYETGPAFQ YADGLEQLRA 


PPS 

« Hide

References

« Hide 'large scale' references
[1]Porcine genome sequencing project
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (MAY-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP016022 Genomic DNA. No translation available.
RefSeqXP_003123090.1. XM_003123042.2.
XP_005654764.1. XM_005654707.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000014724; ENSSSCP00000014326; ENSSSCG00000013478.
GeneID100519411.
KEGGssc:100519411.

Organism-specific databases

CTD83475.

Phylogenomic databases

GeneTreeENSGT00500000044957.
KOK06072.
OMARESCQVA.
OrthoDBEOG75TMCH.
TreeFamTF105626.

Enzyme and pathway databases

UniPathwayUPA00354.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
HAMAPMF_03101. Deoxyhypusine_hydroxylase.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR004155. PBS_lyase_HEAT.
[Graphical view]
PfamPF03130. HEAT_PBS. 1 hit.
[Graphical view]
SMARTSM00567. EZ_HEAT. 6 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF1S8E6_PIG
AccessionPrimary (citable) accession number: F1S8E6
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)