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F1S8E6

- F1S8E6_PIG

UniProt

F1S8E6 - F1S8E6_PIG

Protein

Deoxyhypusine hydroxylase

Gene

DOHH

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.UniRule annotation

    Catalytic activityi

    [eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

    Cofactori

    Binds 2 Fe2+ ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Iron 1UniRule annotation
    Metal bindingi57 – 571Iron 1UniRule annotation
    Metal bindingi89 – 891Iron 1UniRule annotation
    Metal bindingi90 – 901Iron 1UniRule annotation
    Metal bindingi208 – 2081Iron 2UniRule annotation
    Metal bindingi209 – 2091Iron 2UniRule annotation
    Metal bindingi241 – 2411Iron 2UniRule annotation
    Metal bindingi242 – 2421Iron 2UniRule annotation

    GO - Molecular functioni

    1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MonooxygenaseUniRule annotation, Oxidoreductase

    Keywords - Biological processi

    Hypusine biosynthesisUniRule annotation

    Keywords - Ligandi

    IronUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_225348. Hypusine synthesis from eIF5A-lysine.
    UniPathwayiUPA00354.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyhypusine hydroxylaseUniRule annotation (EC:1.14.99.29UniRule annotation)
    Short name:
    DOHHUniRule annotation
    Alternative name(s):
    Deoxyhypusine dioxygenaseUniRule annotation
    Deoxyhypusine monooxygenaseUniRule annotation
    Gene namesi
    Name:DOHHUniRule annotationImported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 2

    Structurei

    3D structure databases

    ProteinModelPortaliF1S8E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati176 – 19924HEAT-like PBS-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the deoxyhypusine hydroxylase family.UniRule annotation
    Contains 1 HEAT-like PBS-type repeat.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00500000044957.
    KOiK06072.
    OMAiRESCQVA.
    OrthoDBiEOG75TMCH.
    TreeFamiTF105626.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view]
    PfamiPF03130. HEAT_PBS. 1 hit.
    [Graphical view]
    SMARTiSM00567. EZ_HEAT. 6 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F1S8E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTEQEVEAV GKMLVDPGQP LQARFRALFT LRGLGGPGAI TWISRAFGDD    50
    SALLKHELAY CLGQMQDSRA IPVLVDVLRD TCQEPMVRHE AGEALGAIGN 100
    PEVLEILKQY STDPVVEVAE TCQLAVRRLE WLQQHSGEPV AQGPYLSVDP 150
    APPAQERDVG QLREMLLDEA QPLFDRYRAM FALRDIGGEE AALALAEGLL 200
    CGSALFRHEI GYVLGQLQHE AAVPHLMAAL ARPAESPMVR HECAEALGAI 250
    ARPACLAALR AYAADPERVV RESCEVALDM YEYETGPAFQ YADGLEQLRA 300
    PPS 303
    Length:303
    Mass (Da):33,037
    Last modified:May 3, 2011 - v1
    Checksum:i5AF4AA0E1CB951D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP016022 Genomic DNA. No translation available.
    RefSeqiXP_003123090.1. XM_003123042.2.
    XP_005654764.1. XM_005654707.1.

    Genome annotation databases

    EnsembliENSSSCT00000014724; ENSSSCP00000014326; ENSSSCG00000013478.
    GeneIDi100519411.
    KEGGissc:100519411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP016022 Genomic DNA. No translation available.
    RefSeqi XP_003123090.1. XM_003123042.2.
    XP_005654764.1. XM_005654707.1.

    3D structure databases

    ProteinModelPortali F1S8E6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000014724 ; ENSSSCP00000014326 ; ENSSSCG00000013478 .
    GeneIDi 100519411.
    KEGGi ssc:100519411.

    Organism-specific databases

    CTDi 83475.

    Phylogenomic databases

    GeneTreei ENSGT00500000044957.
    KOi K06072.
    OMAi RESCQVA.
    OrthoDBi EOG75TMCH.
    TreeFami TF105626.

    Enzyme and pathway databases

    UniPathwayi UPA00354 .
    Reactomei REACT_225348. Hypusine synthesis from eIF5A-lysine.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view ]
    Pfami PF03130. HEAT_PBS. 1 hit.
    [Graphical view ]
    SMARTi SM00567. EZ_HEAT. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Porcine genome sequencing project
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF1S8E6_PIG
    AccessioniPrimary (citable) accession number: F1S8E6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3