ID   F1S7C8_PIG              Unreviewed;       222 AA.
AC   F1S7C8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 3.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE            EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
GN   Name=GSTA4 {ECO:0000313|Ensembl:ENSSSCP00000002836.3};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000002836.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000002836.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000002836.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000002836.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC       {ECO:0000256|ARBA:ARBA00011055}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F1S7C8; -.
DR   STRING; 9823.ENSSSCP00000002836; -.
DR   PaxDb; 9823-ENSSSCP00000002836; -.
DR   PeptideAtlas; F1S7C8; -.
DR   Ensembl; ENSSSCT00000002915.5; ENSSSCP00000002836.3; ENSSSCG00000002627.5.
DR   eggNOG; KOG1695; Eukaryota.
DR   GeneTree; ENSGT00940000162778; -.
DR   HOGENOM; CLU_039475_4_0_1; -.
DR   InParanoid; F1S7C8; -.
DR   OrthoDB; 3412208at2759; -.
DR   TreeFam; TF105321; -.
DR   Reactome; R-SSC-156590; Glutathione conjugation.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Bgee; ENSSSCG00000002627; Expressed in Ammon's horn and 45 other cell types or tissues.
DR   ExpressionAtlas; F1S7C8; baseline and differential.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR   CDD; cd03208; GST_C_Alpha; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR003080; GST_alpha.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR11571:SF123; GLUTATHIONE S-TRANSFERASE A4; 1.
DR   Pfam; PF14497; GST_C_3; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01266; GSTRNSFRASEA.
DR   SFLD; SFLDG01205; AMPS.1; 1.
DR   SFLD; SFLDG00363; AMPS_(cytGST):_Alpha-__Mu-__Pi; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
DR   Genevisible; F1S7C8; SS.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1S7C8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          4..83
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          85..208
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   222 AA;  25241 MW;  26B9FC38973D3789 CRC64;
     MMATKPKLHY PNGRGRMESV RWVLAAAGVE VPSLPIAVSA QISSIPGNHL LFQQVPMVEI
     DGMKLVQTRS ILHYIADKHH LFGKDLKERT LIDMYVEGTL DLLELIIMHP FLKPDDQQKE
     VVNMAQKAII RYFPVFEKVL RGHGQRFLVG NQLSLADIIL LQTILALEEK IPNILSAFPH
     LQEFTVKISN IPTIKKFLEP GSKKKPPPDD IYVRTVYNIF MP
//