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Protein

Fibroblast growth factor

Gene

FGF4

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-SSC-109704. PI3K Cascade.
R-SSC-1257604. PIP3 activates AKT signaling.
R-SSC-190322. FGFR4 ligand binding and activation.
R-SSC-190372. FGFR3c ligand binding and activation.
R-SSC-190373. FGFR1c ligand binding and activation.
R-SSC-190375. FGFR2c ligand binding and activation.
R-SSC-5654219. Phospholipase C-mediated cascade: FGFR1.
R-SSC-5654221. Phospholipase C-mediated cascade, FGFR2.
R-SSC-5654227. Phospholipase C-mediated cascade, FGFR3.
R-SSC-5654228. Phospholipase C-mediated cascade, FGFR4.
R-SSC-5654687. Downstream signaling of activated FGFR1.
R-SSC-5654688. SHC-mediated cascade:FGFR1.
R-SSC-5654689. PI-3K cascade:FGFR1.
R-SSC-5654693. FRS-mediated FGFR1 signaling.
R-SSC-5654695. PI-3K cascade:FGFR2.
R-SSC-5654699. SHC-mediated cascade:FGFR2.
R-SSC-5654700. FRS-mediated FGFR2 signaling.
R-SSC-5654704. SHC-mediated cascade:FGFR3.
R-SSC-5654706. FRS-mediated FGFR3 signaling.
R-SSC-5654710. PI-3K cascade:FGFR3.
R-SSC-5654712. FRS-mediated FGFR4 signaling.
R-SSC-5654719. SHC-mediated cascade:FGFR4.
R-SSC-5654720. PI-3K cascade:FGFR4.
R-SSC-5654726. Negative regulation of FGFR1 signaling.
R-SSC-5654727. Negative regulation of FGFR2 signaling.
R-SSC-5654732. Negative regulation of FGFR3 signaling.
R-SSC-5654733. Negative regulation of FGFR4 signaling.
R-SSC-5673001. RAF/MAP kinase cascade.
R-SSC-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF4Imported
Synonyms:Fgf4Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30UniRule annotationAdd BLAST30
ChainiPRO_501075372831 – 206Fibroblast growth factorUniRule annotationAdd BLAST176

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013681.

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
KOiK04358.
OMAiYNAYESH.
OrthoDBiEOG091G0NAY.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF119. PTHR11486:SF119. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

F1RY80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPGAAAAA LLPAVLLAVL APWAGRGGAA APTAPNRTLE AELERRWESL
60 70 80 90 100
VARSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQVLP
110 120 130 140 150
DGRIGGVHAD TSDSLLELSP VERGVVSIFG VASRFFVAMS SRGKLYGSAF
160 170 180 190 200
FSDECKFKEI LLPNNYNAYE CYRYPGMFIA LSKNGKAKKG NRVSPTMKVT

HFLPRL
Length:206
Mass (Da):22,118
Last modified:May 3, 2011 - v1
Checksum:i4B9D08547AF4EA4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP102526 Genomic DNA. No translation available.
AB745732 Genomic DNA. Translation: BAM74447.1.
AB745733 Genomic DNA. Translation: BAM74448.1.
AB745734 Genomic DNA. Translation: BAM74449.1.
AB745735 Genomic DNA. Translation: BAM74450.1.
AB745736 Genomic DNA. Translation: BAM74451.1.
AB780426 Genomic DNA. Translation: BAM77405.1.
RefSeqiXP_003122466.1. XM_003122418.1.

Genome annotation databases

EnsembliENSSSCT00000014067; ENSSSCP00000013681; ENSSSCG00000012870.
GeneIDi100518595.
KEGGissc:100518595.

Similar proteinsi

Entry informationi

Entry nameiF1RY80_PIG
AccessioniPrimary (citable) accession number: F1RY80
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: August 30, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported