ID F1RR64_PIG Unreviewed; 299 AA. AC F1RR64; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 27-MAR-2024, entry version 68. DE RecName: Full=Endonuclease {ECO:0000256|RuleBase:RU366055}; DE EC=3.1.30.- {ECO:0000256|RuleBase:RU366055}; GN Name=ENDOG {ECO:0000313|Ensembl:ENSSSCP00000006065.2, GN ECO:0000313|VGNC:VGNC:87698}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000006065.2, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000006065.2, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000006065.2, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000006065.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946, CC ECO:0000256|RuleBase:RU366055}; CC -!- SIMILARITY: Belongs to the DNA/RNA non-specific endonuclease family. CC {ECO:0000256|ARBA:ARBA00010052, ECO:0000256|RuleBase:RU366055}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_003122256.1; XM_003122208.3. DR AlphaFoldDB; F1RR64; -. DR SMR; F1RR64; -. DR STRING; 9823.ENSSSCP00000006065; -. DR PaxDb; 9823-ENSSSCP00000006065; -. DR PeptideAtlas; F1RR64; -. DR Ensembl; ENSSSCT00000006224.3; ENSSSCP00000006065.2; ENSSSCG00000005661.3. DR GeneID; 100514888; -. DR KEGG; ssc:100514888; -. DR CTD; 2021; -. DR VGNC; VGNC:87698; ENDOG. DR eggNOG; KOG3721; Eukaryota. DR GeneTree; ENSGT00940000160987; -. DR HOGENOM; CLU_055174_0_1_1; -. DR InParanoid; F1RR64; -. DR OMA; YVMPNQV; -. DR OrthoDB; 5487361at2759; -. DR TreeFam; TF105386; -. DR Proteomes; UP000008227; Chromosome 1. DR Bgee; ENSSSCG00000005661; Expressed in psoas major muscle and 40 other cell types or tissues. DR ExpressionAtlas; F1RR64; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central. DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IBA:GO_Central. DR GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:GO_Central. DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0032043; P:mitochondrial DNA catabolic process; IEA:Ensembl. DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl. DR GO; GO:0090297; P:positive regulation of mitochondrial DNA replication; IEA:Ensembl. DR GO; GO:0046677; P:response to antibiotic; IEA:Ensembl. DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl. DR CDD; cd00091; NUC; 1. DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1. DR InterPro; IPR018524; DNA/RNA_endonuclease_AS. DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease. DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf. DR InterPro; IPR020821; Extracellular_endonuc_su_A. DR InterPro; IPR044925; His-Me_finger_sf. DR InterPro; IPR040255; Non-specific_endonuclease. DR PANTHER; PTHR13966:SF5; ENDONUCLEASE G, MITOCHONDRIAL; 1. DR PANTHER; PTHR13966; ENDONUCLEASE RELATED; 1. DR Pfam; PF01223; Endonuclease_NS; 1. DR SMART; SM00892; Endonuclease_NS; 1. DR SMART; SM00477; NUC; 1. DR SUPFAM; SSF54060; His-Me finger endonucleases; 1. DR PROSITE; PS01070; NUCLEASE_NON_SPEC; 1. DR Genevisible; F1RR64; SS. PE 1: Evidence at protein level; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, KW ECO:0000256|RuleBase:RU366055}; Hydrolase {ECO:0000256|RuleBase:RU366055}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR640255-2, KW ECO:0000256|RuleBase:RU366055}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU366055}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RR64}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..299 FT /note="Endonuclease" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003269673" FT DOMAIN 79..287 FT /note="DNA/RNA non-specific endonuclease" FT /evidence="ECO:0000259|SMART:SM00892" FT DOMAIN 80..287 FT /note="Extracellular Endonuclease subunit A" FT /evidence="ECO:0000259|SMART:SM00477" FT ACT_SITE 143 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR640255-1" FT BINDING 174 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_note="catalytic" FT /evidence="ECO:0000256|PIRSR:PIRSR640255-2" SQ SEQUENCE 299 AA; 32665 MW; 78DC481A668DCC14 CRC64; MKLLRAGLTL ALGAGLGAAA EGWRRQRWDA REAPGLLSRL PVLPVAAAAG LPAVPGAPAG GGPGELAKYG LPGVAQLKSR ESYVLCYDPR TRGAVWVVEQ LRPERLRGDG DRRSCDFHED DSVHAYHRAT NADYRGSGFD RGHLAAAANH RWSQRAMDDT FYLSNVAPQV PHLNQNAWNN LEKYSRSLTR TYQNVYVCTG PLFLPRTEAD GKSYVKYQVI GKNHVAVPTH FFKVLILEAA GGQIELRSYV MPNAPVDEAI PLERFLVPIE SIERASGLLF VPNILARTSS LKAITAGSK //