Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Unconventional myosin-VI

Gene

MYO6

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98ADPCombined sources1
Binding sitei107ADPCombined sources1
Binding sitei200ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 158ATPPROSITE-ProRule annotation8
Nucleotide bindingi154 – 159ADPCombined sources6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-190873 Gap junction degradation
R-SSC-399719 Trafficking of AMPA receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIImported
Gene namesi
Name:MYO6Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiF1RQI7
PRIDEiF1RQI7

Expressioni

Gene expression databases

BgeeiENSSSCG00000004478

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E7SX-ray2.25A/B2-789[»]
4E7ZX-ray2.30A/B2-789[»]
4PFOX-ray1.75A2-789[»]
4PFPX-ray2.32A/C2-789[»]
4PJJX-ray2.40A2-815[»]
4PJLX-ray2.10A2-789[»]
4PJMX-ray2.05A2-789[»]
4PJNX-ray2.00A2-789[»]
4PK4X-ray2.78A2-789[»]
6BNPelectron microscopy4.60I/J/K/L/M/N2-705[»]
6BNQelectron microscopy5.50I/J/K/L/M/N2-705[»]
6BNVelectron microscopy4.60I/J/K/L/M/N2-817[»]
6BNWelectron microscopy5.50I/J/K/L/M/N2-817[»]
SMRiF1RQI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 771Myosin motorInterPro annotationAdd BLAST715

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 673Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili864 – 898Sequence analysisAdd BLAST35
Coiled coili909 – 984Sequence analysisAdd BLAST76
Coiled coili986 – 1009Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
OMAiRICVQGK
OrthoDBiEOG091G01BJ
TreeFamiTF351449

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit

Sequencei

Sequence statusi: Complete.

F1RQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGKPVWAP HPTDGFQVGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKLSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSTQ ALEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GAKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA RLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLSIP RKSKLAIHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGFPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNEIDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLIC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSAL KDGKQEMSKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD
910 920 930 940 950
ALVKSSAVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DPGLRRGPAV QATKAAAGTK
1060 1070 1080 1090 1100
KYDLSKWKYA ELRDTINTSC DIELLAACRE EFHRRLKVYH AWKSKNKKRN
1110 1120 1130 1140 1150
TETEQRAPKS VTDYAQQNPA VQLPARQQEI EMNRQQRFFR IPFIRPADQY
1160 1170 1180 1190 1200
KDPQNKKKGW WYAHFDGPWI ARQMELHPDK PPILLVAGKD DMEMCELNLE
1210 1220 1230 1240 1250
ETGLTRKRGA EILPRQFEEI WERCGGIQYL QNAIESRQAR PTYATAMLQN

LLK
Length:1,253
Mass (Da):144,928
Last modified:May 3, 2011 - v1
Checksum:i3CB3C2C720469A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000001 Genomic DNA No translation available.
RefSeqiXP_005659486.1, XM_005659429.2
XP_005659487.1, XM_005659430.2
UniGeneiSsc.94

Genome annotation databases

EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478
GeneIDi397085

Similar proteinsi

Entry informationi

Entry nameiF1RQI7_PIG
AccessioniPrimary (citable) accession number: F1RQI7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health