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F1RQI7

- F1RQI7_PIG

UniProt

F1RQI7 - F1RQI7_PIG

Protein
Submitted name:

Unconventional myosin-VI

Gene

MYO6

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981ADPImported
    Binding sitei107 – 1071ADPImported
    Binding sitei200 – 2001ADPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi154 – 1596ADPImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    GO - Biological processi

    1. auditory receptor cell differentiation Source: Ensembl
    2. cellular response to electrical stimulus Source: Ensembl
    3. dendrite development Source: Ensembl
    4. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    5. endocytosis Source: Ensembl
    6. glutamate secretion Source: Ensembl
    7. inner ear morphogenesis Source: Ensembl
    8. locomotory behavior Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. protein targeting Source: Ensembl
    11. regulation of secretion Source: Ensembl
    12. regulation of synaptic plasticity Source: Ensembl
    13. sensory perception of sound Source: Ensembl
    14. synapse assembly Source: Ensembl
    15. synaptic transmission Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, MyosinSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_216653. Trafficking of AMPA receptors.
    REACT_218146. Gap junction degradation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Unconventional myosin-VIImported
    Gene namesi
    Name:MYO6Imported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. clathrin-coated endocytic vesicle Source: Ensembl
    3. DNA-directed RNA polymerase II, holoenzyme Source: Ensembl
    4. filamentous actin Source: Ensembl
    5. Golgi apparatus Source: Ensembl
    6. myosin complex Source: UniProtKB-KW
    7. neuronal cell body Source: Ensembl
    8. nuclear membrane Source: Ensembl
    9. plasma membrane Source: Ensembl
    10. ruffle Source: Ensembl
    11. vesicle membrane Source: Ensembl

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E7SX-ray2.25A/B2-789[»]
    4E7ZX-ray2.30A/B2-789[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains myosin motor domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117545.
    KOiK10358.
    OMAiRHKPRID.
    OrthoDBiEOG7TQTZZ.
    TreeFamiTF351449.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    F1RQI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDGKPVWAP HPTDGFQVGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP     50
    AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY 100
    FDIPKIYSSE TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKLSQSIIVS 150
    GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN 200
    NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR 250
    LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY 300
    LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI 350
    DFEEAGSTSG GCNLKNKSTQ ALEYCAELLG LDQDDLRVSL TTRVMLTTAG 400
    GAKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY 450
    FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG 500
    LGVNEVHYVD NQDCIDLIEA RLVGILDILD EENRLPQPSD QHFTSAVHQK 550
    HKDHFRLSIP RKSKLAIHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA 600
    LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ 650
    LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL 700
    MQGGFPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNEIDYK 750
    FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLIC SRWKKVQWCS 800
    LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL 850
    DKFNEVVSAL KDGKQEMSKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD 900
    ALVKSSAVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE 950
    EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ 1000
    AVLEQERRDR ELALRIAQSE AELISDEAQA DPGLRRGPAV QATKAAAGTK 1050
    KYDLSKWKYA ELRDTINTSC DIELLAACRE EFHRRLKVYH AWKSKNKKRN 1100
    TETEQRAPKS VTDYAQQNPA VQLPARQQEI EMNRQQRFFR IPFIRPADQY 1150
    KDPQNKKKGW WYAHFDGPWI ARQMELHPDK PPILLVAGKD DMEMCELNLE 1200
    ETGLTRKRGA EILPRQFEEI WERCGGIQYL QNAIESRQAR PTYATAMLQN 1250
    LLK 1253
    Length:1,253
    Mass (Da):144,928
    Last modified:May 3, 2011 - v1
    Checksum:i3CB3C2C720469A8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469475 Genomic DNA. No translation available.
    RefSeqiXP_005659486.1. XM_005659429.1.
    XP_005659487.1. XM_005659430.1.
    UniGeneiSsc.94.

    Genome annotation databases

    EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478.
    GeneIDi397085.
    KEGGissc:397085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU469475 Genomic DNA. No translation available.
    RefSeqi XP_005659486.1. XM_005659429.1.
    XP_005659487.1. XM_005659430.1.
    UniGenei Ssc.94.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E7S X-ray 2.25 A/B 2-789 [» ]
    4E7Z X-ray 2.30 A/B 2-789 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000004948 ; ENSSSCP00000004831 ; ENSSSCG00000004478 .
    GeneIDi 397085.
    KEGGi ssc:397085.

    Organism-specific databases

    CTDi 4646.

    Phylogenomic databases

    GeneTreei ENSGT00750000117545.
    KOi K10358.
    OMAi RHKPRID.
    OrthoDBi EOG7TQTZZ.
    TreeFami TF351449.

    Enzyme and pathway databases

    Reactomei REACT_216653. Trafficking of AMPA receptors.
    REACT_218146. Gap junction degradation.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Porcine genome sequencing project
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI."
      Menetrey J., Isabet T., Ropars V., Mukherjea M., Pylypenko O., Liu X., Perez J., Vachette P., Sweeney H.L., Houdusse A.M.
      Mol. Cell 48:75-86(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-789 IN COMPLEX WITH ADP.

    Entry informationi

    Entry nameiF1RQI7_PIG
    AccessioniPrimary (citable) accession number: F1RQI7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3