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Protein
Submitted name:

Unconventional myosin-VI

Gene

MYO6

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981ADPCombined sources
Binding sitei107 – 1071ADPCombined sources
Binding sitei200 – 2001ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi154 – 1596ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_303428. Gap junction degradation.
REACT_341983. Trafficking of AMPA receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIImported
Gene namesi
Name:MYO6Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004831.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E7SX-ray2.25A/B2-789[»]
4E7ZX-ray2.30A/B2-789[»]
4PFOX-ray1.75A2-789[»]
4PFPX-ray2.32A/C2-789[»]
4PJJX-ray2.40A2-815[»]
4PJLX-ray2.10A2-789[»]
4PJMX-ray2.05A2-789[»]
4PJNX-ray2.00A2-789[»]
4PK4X-ray2.78A2-789[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains myosin motor domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00790000122950.
KOiK10358.
OMAiRICVQGK.
OrthoDBiEOG7TQTZZ.
TreeFamiTF351449.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1RQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGKPVWAP HPTDGFQVGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKLSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSTQ ALEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GAKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA RLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLSIP RKSKLAIHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGFPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNEIDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLIC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSAL KDGKQEMSKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD
910 920 930 940 950
ALVKSSAVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DPGLRRGPAV QATKAAAGTK
1060 1070 1080 1090 1100
KYDLSKWKYA ELRDTINTSC DIELLAACRE EFHRRLKVYH AWKSKNKKRN
1110 1120 1130 1140 1150
TETEQRAPKS VTDYAQQNPA VQLPARQQEI EMNRQQRFFR IPFIRPADQY
1160 1170 1180 1190 1200
KDPQNKKKGW WYAHFDGPWI ARQMELHPDK PPILLVAGKD DMEMCELNLE
1210 1220 1230 1240 1250
ETGLTRKRGA EILPRQFEEI WERCGGIQYL QNAIESRQAR PTYATAMLQN

LLK
Length:1,253
Mass (Da):144,928
Last modified:May 3, 2011 - v1
Checksum:i3CB3C2C720469A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqiXP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGeneiSsc.94.

Genome annotation databases

EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478.
GeneIDi397085.
KEGGissc:397085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqiXP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGeneiSsc.94.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E7SX-ray2.25A/B2-789[»]
4E7ZX-ray2.30A/B2-789[»]
4PFOX-ray1.75A2-789[»]
4PFPX-ray2.32A/C2-789[»]
4PJJX-ray2.40A2-815[»]
4PJLX-ray2.10A2-789[»]
4PJMX-ray2.05A2-789[»]
4PJNX-ray2.00A2-789[»]
4PK4X-ray2.78A2-789[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478.
GeneIDi397085.
KEGGissc:397085.

Organism-specific databases

CTDi4646.

Phylogenomic databases

GeneTreeiENSGT00790000122950.
KOiK10358.
OMAiRICVQGK.
OrthoDBiEOG7TQTZZ.
TreeFamiTF351449.

Enzyme and pathway databases

ReactomeiREACT_303428. Gap junction degradation.
REACT_341983. Trafficking of AMPA receptors.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI."
    Menetrey J., Isabet T., Ropars V., Mukherjea M., Pylypenko O., Liu X., Perez J., Vachette P., Sweeney H.L., Houdusse A.M.
    Mol. Cell 48:75-86(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-789 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiF1RQI7_PIG
AccessioniPrimary (citable) accession number: F1RQI7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.