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F1RQI7

- F1RQI7_PIG

UniProt

F1RQI7 - F1RQI7_PIG

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Protein
Submitted name:

Unconventional myosin-VI

Gene

MYO6

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981ADPImported
Binding sitei107 – 1071ADPImported
Binding sitei200 – 2001ADPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi154 – 1596ADPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. auditory receptor cell differentiation Source: Ensembl
  2. cellular response to electrical stimulus Source: Ensembl
  3. dendrite development Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  5. endocytosis Source: Ensembl
  6. glutamate secretion Source: Ensembl
  7. inner ear morphogenesis Source: Ensembl
  8. locomotory behavior Source: Ensembl
  9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. protein targeting Source: Ensembl
  11. regulation of secretion Source: Ensembl
  12. regulation of synaptic plasticity Source: Ensembl
  13. sensory perception of sound Source: Ensembl
  14. synapse assembly Source: Ensembl
  15. synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216653. Trafficking of AMPA receptors.
REACT_218146. Gap junction degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIImported
Gene namesi
Name:MYO6Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. clathrin-coated endocytic vesicle Source: Ensembl
  3. DNA-directed RNA polymerase II, holoenzyme Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. filamentous actin Source: Ensembl
  6. Golgi apparatus Source: Ensembl
  7. myosin complex Source: UniProtKB-KW
  8. neuronal cell body Source: Ensembl
  9. nuclear membrane Source: Ensembl
  10. plasma membrane Source: Ensembl
  11. ruffle Source: Ensembl
  12. vesicle membrane Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E7SX-ray2.25A/B2-789[»]
4E7ZX-ray2.30A/B2-789[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains myosin motor domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120461.
KOiK10358.
OMAiRHKPRID.
OrthoDBiEOG7TQTZZ.
TreeFamiTF351449.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

F1RQI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDGKPVWAP HPTDGFQVGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKLSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSTQ ALEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GAKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA RLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLSIP RKSKLAIHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGFPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNEIDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLIC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSAL KDGKQEMSKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD
910 920 930 940 950
ALVKSSAVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DPGLRRGPAV QATKAAAGTK
1060 1070 1080 1090 1100
KYDLSKWKYA ELRDTINTSC DIELLAACRE EFHRRLKVYH AWKSKNKKRN
1110 1120 1130 1140 1150
TETEQRAPKS VTDYAQQNPA VQLPARQQEI EMNRQQRFFR IPFIRPADQY
1160 1170 1180 1190 1200
KDPQNKKKGW WYAHFDGPWI ARQMELHPDK PPILLVAGKD DMEMCELNLE
1210 1220 1230 1240 1250
ETGLTRKRGA EILPRQFEEI WERCGGIQYL QNAIESRQAR PTYATAMLQN

LLK
Length:1,253
Mass (Da):144,928
Last modified:May 3, 2011 - v1
Checksum:i3CB3C2C720469A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqiXP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGeneiSsc.94.

Genome annotation databases

EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478.
GeneIDi397085.
KEGGissc:397085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqi XP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGenei Ssc.94.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E7S X-ray 2.25 A/B 2-789 [» ]
4E7Z X-ray 2.30 A/B 2-789 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000004948 ; ENSSSCP00000004831 ; ENSSSCG00000004478 .
GeneIDi 397085.
KEGGi ssc:397085.

Organism-specific databases

CTDi 4646.

Phylogenomic databases

GeneTreei ENSGT00770000120461.
KOi K10358.
OMAi RHKPRID.
OrthoDBi EOG7TQTZZ.
TreeFami TF351449.

Enzyme and pathway databases

Reactomei REACT_216653. Trafficking of AMPA receptors.
REACT_218146. Gap junction degradation.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI."
    Menetrey J., Isabet T., Ropars V., Mukherjea M., Pylypenko O., Liu X., Perez J., Vachette P., Sweeney H.L., Houdusse A.M.
    Mol. Cell 48:75-86(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-789 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiF1RQI7_PIG
AccessioniPrimary (citable) accession number: F1RQI7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3