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F1RQI7

- F1RQI7_PIG

UniProt

F1RQI7 - F1RQI7_PIG

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Protein
Submitted name: Unconventional myosin-VI
Gene
MYO6
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981ADPImported
Binding sitei107 – 1071ADPImported
Binding sitei200 – 2001ADPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi154 – 1596ADPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  2. auditory receptor cell differentiation Source: Ensembl
  3. cellular response to electrical stimulus Source: Ensembl
  4. dendrite development Source: Ensembl
  5. endocytosis Source: Ensembl
  6. glutamate secretion Source: Ensembl
  7. inner ear morphogenesis Source: Ensembl
  8. locomotory behavior Source: Ensembl
  9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. protein targeting Source: Ensembl
  11. regulation of secretion Source: Ensembl
  12. regulation of synaptic plasticity Source: Ensembl
  13. sensory perception of sound Source: Ensembl
  14. synapse assembly Source: Ensembl
  15. synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216653. Trafficking of AMPA receptors.
REACT_218146. Gap junction degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIImported
Gene namesi
Name:MYO6Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, holoenzyme Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. axon Source: Ensembl
  4. clathrin-coated endocytic vesicle Source: Ensembl
  5. filamentous actin Source: Ensembl
  6. myosin complex Source: UniProtKB-KW
  7. neuronal cell body Source: Ensembl
  8. nuclear membrane Source: Ensembl
  9. plasma membrane Source: Ensembl
  10. ruffle Source: Ensembl
  11. vesicle membrane Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E7SX-ray2.25A/B2-789[»]
4E7ZX-ray2.30A/B2-789[»]

Family & Domainsi

Sequence similaritiesi

Contains myosin motor domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117545.
KOiK10358.
OMAiRHKPRID.
OrthoDBiEOG7TQTZZ.
TreeFamiTF351449.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

F1RQI7-1 [UniParc]FASTAAdd to Basket

« Hide

MEDGKPVWAP HPTDGFQVGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP     50
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY 100
FDIPKIYSSE TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKLSQSIIVS 150
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN 200
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR 250
LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY 300
LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI 350
DFEEAGSTSG GCNLKNKSTQ ALEYCAELLG LDQDDLRVSL TTRVMLTTAG 400
GAKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY 450
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG 500
LGVNEVHYVD NQDCIDLIEA RLVGILDILD EENRLPQPSD QHFTSAVHQK 550
HKDHFRLSIP RKSKLAIHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA 600
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ 650
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL 700
MQGGFPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNEIDYK 750
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLIC SRWKKVQWCS 800
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL 850
DKFNEVVSAL KDGKQEMSKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD 900
ALVKSSAVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE 950
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ 1000
AVLEQERRDR ELALRIAQSE AELISDEAQA DPGLRRGPAV QATKAAAGTK 1050
KYDLSKWKYA ELRDTINTSC DIELLAACRE EFHRRLKVYH AWKSKNKKRN 1100
TETEQRAPKS VTDYAQQNPA VQLPARQQEI EMNRQQRFFR IPFIRPADQY 1150
KDPQNKKKGW WYAHFDGPWI ARQMELHPDK PPILLVAGKD DMEMCELNLE 1200
ETGLTRKRGA EILPRQFEEI WERCGGIQYL QNAIESRQAR PTYATAMLQN 1250
LLK 1253
Length:1,253
Mass (Da):144,928
Last modified:May 3, 2011 - v1
Checksum:i3CB3C2C720469A8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqiXP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGeneiSsc.94.

Genome annotation databases

EnsembliENSSSCT00000004948; ENSSSCP00000004831; ENSSSCG00000004478.
GeneIDi397085.
KEGGissc:397085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU469475 Genomic DNA. No translation available.
RefSeqi XP_005659486.1. XM_005659429.1.
XP_005659487.1. XM_005659430.1.
UniGenei Ssc.94.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E7S X-ray 2.25 A/B 2-789 [» ]
4E7Z X-ray 2.30 A/B 2-789 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000004948 ; ENSSSCP00000004831 ; ENSSSCG00000004478 .
GeneIDi 397085.
KEGGi ssc:397085.

Organism-specific databases

CTDi 4646.

Phylogenomic databases

GeneTreei ENSGT00750000117545.
KOi K10358.
OMAi RHKPRID.
OrthoDBi EOG7TQTZZ.
TreeFami TF351449.

Enzyme and pathway databases

Reactomei REACT_216653. Trafficking of AMPA receptors.
REACT_218146. Gap junction degradation.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI."
    Menetrey J., Isabet T., Ropars V., Mukherjea M., Pylypenko O., Liu X., Perez J., Vachette P., Sweeney H.L., Houdusse A.M.
    Mol. Cell 48:75-86(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-789 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiF1RQI7_PIG
AccessioniPrimary (citable) accession number: F1RQI7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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