ID   A0A4X1T661_PIG          Unreviewed;       461 AA.
AC   A0A4X1T661; F1RF26;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Serine incorporator 5 {ECO:0000256|ARBA:ARBA00021252};
GN   Name=SERINC5 {ECO:0000313|Ensembl:ENSSSCP00005010114.1,
GN   ECO:0000313|VGNC:VGNC:92730};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00005010114.1};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000015014.5, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000015014.5,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00005010114.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TDE1 family.
CC       {ECO:0000256|ARBA:ARBA00006665}.
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DR   RefSeq; XP_013850400.1; XM_013994946.1.
DR   STRING; 9823.ENSSSCP00000015014; -.
DR   PaxDb; 9823-ENSSSCP00000015014; -.
DR   Ensembl; ENSSSCT00000015423.5; ENSSSCP00000015014.5; ENSSSCG00000014119.5.
DR   Ensembl; ENSSSCT00005016983.1; ENSSSCP00005010114.1; ENSSSCG00005010922.1.
DR   GeneID; 100624743; -.
DR   KEGG; ssc:100624743; -.
DR   CTD; 256987; -.
DR   VGNC; VGNC:92730; SERINC5.
DR   eggNOG; KOG2592; Eukaryota.
DR   GeneTree; ENSGT01030000234623; -.
DR   HOGENOM; CLU_029574_5_2_1; -.
DR   OMA; LCCVMMS; -.
DR   OrthoDB; 53161at2759; -.
DR   TreeFam; TF312881; -.
DR   Reactome; R-SSC-977347; Serine biosynthesis.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Bgee; ENSSSCG00000014119; Expressed in granulosa cell and 47 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0009597; P:detection of virus; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR   PANTHER; PTHR10383:SF16; SERINE INCORPORATOR 5; 1.
DR   Pfam; PF03348; Serinc; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   461 AA;  51320 MW;  49404DA5D700A3AB CRC64;
     MSAQCCAGQL ACCCGNAGCS FCCGCCPKIR QSRSTRFMYA LYFILVVILC CIMMSNTVAN
     EMRERIPFFE DICKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KVNNSKSCRA
     YIHNGFWFFK LLLLGAMCSG AFFIPDQETF LNAWRYVGAI GGFLFIGIQL LLIVEFAHKW
     NKNWTAGTAT NKLWYACLSL VTLIMYSIAT GGLILMAVFY TQKDGCMENK ILLGVNGGLC
     LLISVVAISP CVQDRQPHSG LLQSGLISCY VTYLTFSALS SKPVEVVLDE HGKNVTICVP
     DFGQDLYRDK NLVAGLGTSL LCACILYSCL TSTTRSSSDA LQGRYGAPEL EVARCCFCFS
     SGGEDTEEQQ NVKEGPRVIY DEKKSTVYTY SYFHFVFFLA SLYVMMTITN WFNYESANIE
     SFFSGSWSIF WVKMASCWIC VLLYLGTLIA PLCRPSPQFS V
//