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Protein

Metalloendopeptidase

Gene

bmp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi202 – 2021Zinc; catalyticUniRule annotation
Active sitei203 – 2031UniRule annotation
Metal bindingi206 – 2061Zinc; catalyticUniRule annotation
Metal bindingi212 – 2121Zinc; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • determination of ventral identity Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • fin development Source: ZFIN
  • ossification Source: ZFIN
  • proteolysis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-1474228. Degradation of the extracellular matrix.
R-DRE-1650814. Collagen biosynthesis and modifying enzymes.
R-DRE-194223. HDL-mediated lipid transport.
R-DRE-2214320. Anchoring fibril formation.
R-DRE-2243919. Crosslinking of collagen fibrils.

Protein family/group databases

MEROPSiM12.005.

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:bmp1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-060818-1. bmp1a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919UniRule annotationAdd
BLAST
Chaini20 – 976957MetalloendopeptidaseUniRule annotationPRO_5005968467Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1REM3.

Expressioni

Gene expression databases

BgeeiF1REM3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini311 – 423113CUBInterPro annotationAdd
BLAST
Domaini424 – 536113CUBInterPro annotationAdd
BLAST
Domaini536 – 57742EGF-likeInterPro annotationAdd
BLAST
Domaini580 – 692113CUBInterPro annotationAdd
BLAST
Domaini692 – 73241EGF-likeInterPro annotationAdd
BLAST
Domaini736 – 848113CUBInterPro annotationAdd
BLAST
Domaini849 – 965117CUBInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotationSAAS annotation
Contains 2 EGF-like domains.UniRule annotation
Contains 5 CUB domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119018.
InParanoidiF1REM3.
OrthoDBiEOG7N8ZTV.
TreeFamiTF314351.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1REM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAARCALL LSSFSLLAAL DLDAIEPGYY VETSSPSDLI DYKDPCKAVA
60 70 80 90 100
YLGDIALDEE DMRMFTVDRI VNLADRTVTI LNHTNTGSLS NETSVNTTAS
110 120 130 140 150
SRGSHRRRRA ATSRPERVWP EGVIPYVISG NFSGSQRAIF RQAMRHWEKH
160 170 180 190 200
TCVTFIERTT EESYIVFTYR PCGCCSYVGR RGGGPQAISI GKNCDKFGIV
210 220 230 240 250
VHELGHVIGF WHEHTRPDRD EHVSIIRDNI QPGQEYNFLK MEPGEVDSLG
260 270 280 290 300
EVYDFDSIMH YARNTFSRGI FLDTILPRYD VNGVRPPIGQ RTRLSKGDIA
310 320 330 340 350
QARKLYKCPR CGDSLQESSG NFSSPGYPNG YSAYMHCIWR ISVTPGEKII
360 370 380 390 400
LNFTSMDLYR SHLCWYDHVE IRDGYWRKAP LKGRFCGDKL PDPIISTDSR
410 420 430 440 450
LWIEFRSSSN WVGKGFSAVY EAICGGEVKK DNGQIQSPNY PDDYRPNKVC
460 470 480 490 500
VWKITVAQGY HVGLTFQSFE IERHDNCAYD YLEVRDGNSE SSPLLGRFCG
510 520 530 540 550
YDKPDDIKSS SNQLWMKFVS DGSVNKAGFA ANFFKEMDEC SRPDNGRCEQ
560 570 580 590 600
RCVNTLGSYK CACDPGYELA ADKRSCEAAC GGFITKLNGS ITSPGWPKEY
610 620 630 640 650
PPNKNCIWQL VAPTQYRITL LFDVFETEGN DVCKYDFVEV RSGLSADSRL
660 670 680 690 700
HGKFCGAEKP EAITSQYNNM RIEFKSDNTV SKKGFKAQFF SDKDECSKEN
710 720 730 740 750
GGCQHECVNT FGSYSCQCRS GFVLHENKHD CKEAGCDHVV NSVSGTITSP
760 770 780 790 800
NWPDKYPSKK ACTWALSTTP GHRIKIAFNE IDMEPHLECA YDHIEIYDGR
810 820 830 840 850
DSKAQSLGRY CGTKKPQPII STGNKMFIRF FSDNSVQKKG FEASHTAECG
860 870 880 890 900
GRLKAEVKTK DLYSHAQFGD NNYPGASDCQ WVITAEKGYG VELIFQTFEI
910 920 930 940 950
EEEADCGYDY MELFDGADTK SPRLGRYCGS GPPEEIYSAG DSIVIKFHSD
960 970
DTINKKGFHV RYTSTKFQDT LHSRKK
Length:976
Mass (Da):109,940
Last modified:January 20, 2016 - v2
Checksum:i49050ABF91ADD3E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01076510 Genomic DNA. No translation available.
CABZ01076511 Genomic DNA. No translation available.
CABZ01076512 Genomic DNA. No translation available.
CABZ01076513 Genomic DNA. No translation available.
CABZ01076514 Genomic DNA. No translation available.
CABZ01076515 Genomic DNA. No translation available.
CABZ01076516 Genomic DNA. No translation available.
CABZ01098093 Genomic DNA. No translation available.
CABZ01115210 Genomic DNA. No translation available.
FQ859177 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000127875; ENSDARP00000112455; ENSDARG00000028071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01076510 Genomic DNA. No translation available.
CABZ01076511 Genomic DNA. No translation available.
CABZ01076512 Genomic DNA. No translation available.
CABZ01076513 Genomic DNA. No translation available.
CABZ01076514 Genomic DNA. No translation available.
CABZ01076515 Genomic DNA. No translation available.
CABZ01076516 Genomic DNA. No translation available.
CABZ01098093 Genomic DNA. No translation available.
CABZ01115210 Genomic DNA. No translation available.
FQ859177 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112455.

Protein family/group databases

MEROPSiM12.005.

Proteomic databases

PaxDbiF1REM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000127875; ENSDARP00000112455; ENSDARG00000028071.

Organism-specific databases

ZFINiZDB-GENE-060818-1. bmp1a.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119018.
InParanoidiF1REM3.
OrthoDBiEOG7N8ZTV.
TreeFamiTF314351.

Enzyme and pathway databases

ReactomeiR-DRE-1474228. Degradation of the extracellular matrix.
R-DRE-1650814. Collagen biosynthesis and modifying enzymes.
R-DRE-194223. HDL-mediated lipid transport.
R-DRE-2214320. Anchoring fibril formation.
R-DRE-2243919. Crosslinking of collagen fibrils.

Gene expression databases

BgeeiF1REM3.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1REM3_DANRE
AccessioniPrimary (citable) accession number: F1REM3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: January 20, 2016
Last modified: May 11, 2016
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.