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Protein

Metalloendopeptidase

Gene

bmp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi202Zinc; catalyticUniRule annotation1
Active sitei203UniRule annotation1
Metal bindingi206Zinc; catalyticUniRule annotation1
Metal bindingi212Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • determination of ventral identity Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • fin development Source: ZFIN
  • ossification Source: ZFIN
  • proteolysis Source: ZFIN

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-1474228 Degradation of the extracellular matrix
R-DRE-1650814 Collagen biosynthesis and modifying enzymes
R-DRE-2214320 Anchoring fibril formation
R-DRE-2243919 Crosslinking of collagen fibrils
R-DRE-8963896 HDL assembly

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:bmp1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-060818-1 bmp1a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_500596846720 – 976MetalloendopeptidaseUniRule annotationAdd BLAST957

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1REM3

Expressioni

Gene expression databases

BgeeiENSDARG00000028071

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112455

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini311 – 423CUBInterPro annotationAdd BLAST113
Domaini424 – 536CUBInterPro annotationAdd BLAST113
Domaini536 – 577EGF-likeInterPro annotationAdd BLAST42
Domaini580 – 692CUBInterPro annotationAdd BLAST113
Domaini692 – 732EGF-likeInterPro annotationAdd BLAST41
Domaini736 – 848CUBInterPro annotationAdd BLAST113
Domaini849 – 965CUBInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotationSAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
InParanoidiF1REM3
OMAiKGFEASH
OrthoDBiEOG091G009U
TreeFamiTF314351

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

F1REM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAARCALL LSSFSLLAAL DLDAIEPGYY VETSSPSDLI DYKDPCKAVA
60 70 80 90 100
YLGDIALDEE DMRMFTVDRI VNLADRTVTI LNHTNTGSLS NETSVNTTAS
110 120 130 140 150
SRGSHRRRRA ATSRPERVWP EGVIPYVISG NFSGSQRAIF RQAMRHWEKH
160 170 180 190 200
TCVTFIERTT EESYIVFTYR PCGCCSYVGR RGGGPQAISI GKNCDKFGIV
210 220 230 240 250
VHELGHVIGF WHEHTRPDRD EHVSIIRDNI QPGQEYNFLK MEPGEVDSLG
260 270 280 290 300
EVYDFDSIMH YARNTFSRGI FLDTILPRYD VNGVRPPIGQ RTRLSKGDIA
310 320 330 340 350
QARKLYKCPR CGDSLQESSG NFSSPGYPNG YSAYMHCIWR ISVTPGEKII
360 370 380 390 400
LNFTSMDLYR SHLCWYDHVE IRDGYWRKAP LKGRFCGDKL PDPIISTDSR
410 420 430 440 450
LWIEFRSSSN WVGKGFSAVY EAICGGEVKK DNGQIQSPNY PDDYRPNKVC
460 470 480 490 500
VWKITVAQGY HVGLTFQSFE IERHDNCAYD YLEVRDGNSE SSPLLGRFCG
510 520 530 540 550
YDKPDDIKSS SNQLWMKFVS DGSVNKAGFA ANFFKEMDEC SRPDNGRCEQ
560 570 580 590 600
RCVNTLGSYK CACDPGYELA ADKRSCEAAC GGFITKLNGS ITSPGWPKEY
610 620 630 640 650
PPNKNCIWQL VAPTQYRITL LFDVFETEGN DVCKYDFVEV RSGLSADSRL
660 670 680 690 700
HGKFCGAEKP EAITSQYNNM RIEFKSDNTV SKKGFKAQFF SDKDECSKEN
710 720 730 740 750
GGCQHECVNT FGSYSCQCRS GFVLHENKHD CKEAGCDHVV NSVSGTITSP
760 770 780 790 800
NWPDKYPSKK ACTWALSTTP GHRIKIAFNE IDMEPHLECA YDHIEIYDGR
810 820 830 840 850
DSKAQSLGRY CGTKKPQPII STGNKMFIRF FSDNSVQKKG FEASHTAECG
860 870 880 890 900
GRLKAEVKTK DLYSHAQFGD NNYPGASDCQ WVITAEKGYG VELIFQTFEI
910 920 930 940 950
EEEADCGYDY MELFDGADTK SPRLGRYCGS GPPEEIYSAG DSIVIKFHSD
960 970
DTINKKGFHV RYTSTKFQDT LHSRKK
Length:976
Mass (Da):109,940
Last modified:January 20, 2016 - v2
Checksum:i49050ABF91ADD3E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01076510 Genomic DNA No translation available.
CABZ01076511 Genomic DNA No translation available.
CABZ01076512 Genomic DNA No translation available.
CABZ01076513 Genomic DNA No translation available.
CABZ01076514 Genomic DNA No translation available.
CABZ01076515 Genomic DNA No translation available.
CABZ01076516 Genomic DNA No translation available.
CABZ01098093 Genomic DNA No translation available.
CABZ01115210 Genomic DNA No translation available.
FQ859177 Genomic DNA No translation available.
RefSeqiXP_017212854.1, XM_017357365.1
UniGeneiDr.152060

Genome annotation databases

EnsembliENSDART00000127875; ENSDARP00000112455; ENSDARG00000028071
GeneIDi572452

Similar proteinsi

Entry informationi

Entry nameiF1REM3_DANRE
AccessioniPrimary (citable) accession number: F1REM3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: January 20, 2016
Last modified: May 23, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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