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Protein

Tyrosine-protein kinase fynb

Gene

fynb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mn2+By similarity

Enzyme regulationi

Inhibited by phosphorylation of Tyr-538 by leukocyte common antigen and activated by dephosphorylation of this site.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei306ATPPROSITE-ProRule annotation1
Active sitei397Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi284 – 292ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-114604 GPVI-mediated activation cascade
R-DRE-1227986 Signaling by ERBB2
R-DRE-1433557 Signaling by SCF-KIT
R-DRE-202733 Cell surface interactions at the vascular wall
R-DRE-2029481 FCGR activation
R-DRE-2424491 DAP12 signaling
R-DRE-373753 Nephrin family interactions
R-DRE-375165 NCAM signaling for neurite out-growth
R-DRE-3928662 EPHB-mediated forward signaling
R-DRE-3928664 Ephrin signaling
R-DRE-3928665 EPH-ephrin mediated repulsion of cells
R-DRE-399954 Sema3A PAK dependent Axon repulsion
R-DRE-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DRE-399956 CRMPs in Sema3A signaling
R-DRE-418885 DCC mediated attractive signaling
R-DRE-4420097 VEGFA-VEGFR2 Pathway
R-DRE-5621575 CD209 (DC-SIGN) signaling
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-75892 Platelet Adhesion to exposed collagen
R-DRE-8866376 Reelin signalling pathway
R-DRE-912631 Regulation of signaling by CBL

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase fynb (EC:2.7.10.2)
Alternative name(s):
Proto-oncogene c-Fynb
Gene namesi
Name:fynb
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050706-89 fynb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004188792 – 544Tyrosine-protein kinase fynbAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi6S-palmitoyl cysteineBy similarity1
Modified residuei427Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei538PhosphotyrosineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiF1RDG9
PRIDEiF1RDG9

Expressioni

Gene expression databases

BgeeiENSDARG00000025319

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000037198

Structurei

3D structure databases

ProteinModelPortaliF1RDG9
SMRiF1RDG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 150SH3PROSITE-ProRule annotationAdd BLAST62
Domaini156 – 253SH2PROSITE-ProRule annotationAdd BLAST98
Domaini278 – 531Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
HOGENOMiHOG000233858
InParanoidiF1RDG9
KOiK05703
OMAiQCWKKDA
OrthoDBiEOG091G0D46
TreeFamiTF351634

Family and domain databases

CDDicd12006 SH3_Fyn_Yrk, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035750 Fyn/Yrk_SH3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F1RDG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVQCKDKE AAKLTDDRDT SLSQSGVGYR YGVDPTPQHY PAFSGTGTAV
60 70 80 90 100
AAIPNYNNFH GAAVSQGMTV FGGISTSTHQ GTLRTRGGTG VTLFVALYDY
110 120 130 140 150
EARTEDDLSF RKGEKFQIIN STEGDWWDAR SLTTGGTGYI PSNYVAPVDS
160 170 180 190 200
IQAEDWYFGK LGRKDAERQL LSTGNPRGTF LIRESETTKG AFSLSIRDWD
210 220 230 240 250
DVKGDHVKHY KIRKLDSGGY YITTRAQFET LQQLVQHYTE RAAGLCCRLV
260 270 280 290 300
VPCHKGMPRL TDLSVKTKDV WEIPRESLQL IKRLGNGQFG EVWMGTWNGN
310 320 330 340 350
TKVAIKTLKP GTMSPESFLE EAQIMKKLRH DKLVQLYAVV SEEPIYIVTE
360 370 380 390 400
YMGKGSLLDF LKDGEGRALK LPNLVDMAAQ VAGGMAYIER MNYIHRDLRS
410 420 430 440 450
ANILVGDSLV CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGKF
460 470 480 490 500
TIKSDVWSFG ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMQCPQDCPS
510 520 530 540
SLHELMVQCW KKDAEERPTF EYLQAFLEDY FTATEPQYQP GDNL
Length:544
Mass (Da):61,030
Last modified:May 3, 2011 - v1
Checksum:i287C2FCF09C51B15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65S → P in AAH98534 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954744 Genomic DNA No translation available.
FP015917 Genomic DNA No translation available.
BC098534 mRNA Translation: AAH98534.1
RefSeqiNP_001025140.1, NM_001029969.1
XP_005160359.1, XM_005160302.3
UniGeneiDr.134137

Genome annotation databases

EnsembliENSDART00000036635; ENSDARP00000037198; ENSDARG00000025319
ENSDART00000169407; ENSDARP00000133954; ENSDARG00000025319
GeneIDi574422
KEGGidre:574422

Similar proteinsi

Entry informationi

Entry nameiFYNB_DANRE
AccessioniPrimary (citable) accession number: F1RDG9
Secondary accession number(s): Q4KMJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health