Tyrosine-protein kinase fynb - Danio rerio (Zebrafish)

Contribute

Send feedback

Read comments (?) or add your own

F1RDG9 (FYNB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 17. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase fynb
EC=2.7.10.2

Alternative name(s):
Proto-oncogene c-Fynb

Gene names

Name:

fynb

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cofactor	Manganese By similarity.
Enzyme regulation	Inhibited by phosphorylation of Tyr-538 by leukocyte common antigen and activated by dephosphorylation of this site By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Proto-oncogene
Domain	SH2 domain SH3 domain
Ligand	ATP-binding Manganese Metal-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Transferase Tyrosine-protein kinase
PTM	Lipoprotein Myristate Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	convergent extension involved in gastrulation Inferred from genetic interaction PubMed 15815683. Source: ZFIN regulation of protein kinase activity Inferred from genetic interaction PubMed 17611617 PubMed 18550893. Source: ZFIN
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 544

543

Tyrosine-protein kinase fynb

PRO_0000418879

Regions

Domain

89 – 150

SH3

Domain

156 – 253

SH2

Domain

278 – 531

254

Protein kinase

Nucleotide binding

284 – 292

ATP By similarity

Sites

Active site

397

Proton acceptor By similarity

Binding site

306

ATP By similarity

Amino acid modifications

Modified residue

427

Phosphotyrosine; by autocatalysis By similarity

Modified residue

538

Phosphotyrosine By similarity

Lipidation

N-myristoyl glycine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Experimental info

Sequence conflict

S → P in AAH98534. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

F1RDG9 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 287C2FCF09C51B15
Show »

FASTA

544

61,030

        10         20         30         40         50         60 
MGCVQCKDKE AAKLTDDRDT SLSQSGVGYR YGVDPTPQHY PAFSGTGTAV AAIPNYNNFH 

        70         80         90        100        110        120 
GAAVSQGMTV FGGISTSTHQ GTLRTRGGTG VTLFVALYDY EARTEDDLSF RKGEKFQIIN 

       130        140        150        160        170        180 
STEGDWWDAR SLTTGGTGYI PSNYVAPVDS IQAEDWYFGK LGRKDAERQL LSTGNPRGTF 

       190        200        210        220        230        240 
LIRESETTKG AFSLSIRDWD DVKGDHVKHY KIRKLDSGGY YITTRAQFET LQQLVQHYTE 

       250        260        270        280        290        300 
RAAGLCCRLV VPCHKGMPRL TDLSVKTKDV WEIPRESLQL IKRLGNGQFG EVWMGTWNGN 

       310        320        330        340        350        360 
TKVAIKTLKP GTMSPESFLE EAQIMKKLRH DKLVQLYAVV SEEPIYIVTE YMGKGSLLDF 

       370        380        390        400        410        420 
LKDGEGRALK LPNLVDMAAQ VAGGMAYIER MNYIHRDLRS ANILVGDSLV CKIADFGLAR 

       430        440        450        460        470        480 
LIEDNEYTAR QGAKFPIKWT APEAALYGKF TIKSDVWSFG ILLTELVTKG RVPYPGMNNR 

       490        500        510        520        530        540 
EVLEQVERGY RMQCPQDCPS SLHELMVQCW KKDAEERPTF EYLQAFLEDY FTATEPQYQP 


GDNL

« Hide

References

[1]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL954744 Genomic DNA. No translation available. FP015917 Genomic DNA. No translation available. BC098534 mRNA. Translation: AAH98534.1.
IPI	IPI00512478.
RefSeq	NP_001025140.1. NM_001029969.1.
UniGene	Dr.134137.
3D structure databases
ProteinModelPortal	F1RDG9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000036635; ENSDARP00000037198; ENSDARG00000025319.
GeneID	574422.
KEGG	dre:574422.
Organism-specific databases
CTD	574422.
ZFIN	ZDB-GENE-050706-89. fynb.
Phylogenomic databases
GeneTree	ENSGT00620000087702.
KO	K05703.
Gene expression databases
Bgee	F1RDG9.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20891930.

Entry information

Entry name

FYNB_DANRE

Accession

Primary (citable) accession number: F1RDG9
Secondary accession number(s): Q4KMJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2012
Last sequence update:	May 3, 2011
Last modified:	March 6, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents