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Protein
Submitted name:

Glucagon receptor b

Gene

gcgrb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • gastric inhibitory peptide receptor activity Source: InterPro
  • peptide hormone binding Source: ZFIN

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • regulation of glucose metabolic process Source: ZFIN

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-163359. Glucagon signaling in metabolic regulation.
R-DRE-416476. G alpha (q) signalling events.
R-DRE-418555. G alpha (s) signalling events.
R-DRE-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucagon receptor bImported
Gene namesi
Name:gcgrbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-050516-2. gcgrb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei129 – 150HelicalSequence analysisAdd BLAST22
Transmembranei251 – 270HelicalSequence analysisAdd BLAST20
Transmembranei290 – 313HelicalSequence analysisAdd BLAST24
Transmembranei334 – 356HelicalSequence analysisAdd BLAST23
Transmembranei368 – 392HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500326916122 – 509Sequence analysisAdd BLAST488

Proteomic databases

PaxDbiF1RCQ6.

Expressioni

Gene expression databases

BgeeiENSDARG00000036272.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013211.

Structurei

3D structure databases

ProteinModelPortaliF1RCQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 114G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST78
Domaini127 – 393G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
InParanoidiF1RCQ6.
OMAiNTSECED.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Family and domain databases

Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR036445. GPCR_2_extracell_dom_sf.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

F1RCQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLLLVLF ILTTHTQVSS GKSLKLLQEQ WRIYTNECIQ SFISTPPAAG
60 70 80 90 100
LVCNRTFDQY VCWPDGLPGT TVNVSCPWYL PWYSKVDHGL VYRVCGADGR
110 120 130 140 150
WVHGKNTSEC EQDDPGQKQY GQILSKFRAM YTVGYSLSLA ALTLALGILV
160 170 180 190 200
SFRKLHCMRN NIHMNLFGSF MVRALSILIK DTLLDQMNRA RSGPSHYQST
210 220 230 240 250
RWLDTQTVVG CRSAMVMMQY SVMANNCWLL VEGLYLHSLL VTTVFSERNY
260 270 280 290 300
FCIYLCIGWG APLIFVLPWM TVKYLYENEE CWERNMNMGY WWIIRSPILF
310 320 330 340 350
AYLINFIIFI RIIKILMSKL KAHQMRYTDY KFRLAKSTLT LIPLLGIHAV
360 370 380 390 400
LFTFVIDESV PKESLLRLIR LFYDLLFSSF QGLLVAILYC FVNKEVQSEM
410 420 430 440 450
LKKWKRWKLG KDIDEEYRHT HSQTPHAKSS TAPPAAHDCP DTSSSLESQR
460 470 480 490 500
LVTGLQNGLS RSRGRARLQF TSQTQEGASN CSSLTEDICL EERPLNNEGS

AAVLEETNV
Length:509
Mass (Da):58,358
Last modified:June 26, 2013 - v2
Checksum:iD5EAF4716D9AAA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928676 Genomic DNA. No translation available.
RefSeqiXP_009293538.1. XM_009295263.2.

Genome annotation databases

EnsembliENSDART00000021878; ENSDARP00000013211; ENSDARG00000036272.
GeneIDi565237.

Similar proteinsi

Entry informationi

Entry nameiF1RCQ6_DANRE
AccessioniPrimary (citable) accession number: F1RCQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: November 22, 2017
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported