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Protein
Submitted name:

Ubiquitin-like modifier-activating enzyme 1

Gene

uba1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei632Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: ZFIN
  • cellular response to DNA damage stimulus Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: GO_Central

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-like modifier-activating enzyme 1Imported
Gene namesi
Name:uba1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040426-2009 uba1

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiF1RCA1
PRIDEiF1RCA1

Expressioni

Gene expression databases

BgeeiENSDARG00000037559
ExpressionAtlasiF1RCA1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054690

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini922 – 1053UBA_e1_CInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2012 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00390000016689
InParanoidiF1RCA1
OMAiLKNWSMM
OrthoDBiEOG091G0130
TreeFamiTF300586

Family and domain databases

Gene3Di3.10.290.60, 1 hit
InterProiView protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR035985 Ubiquitin-activating_enz
IPR018075 UBQ-activ_enz_E1
IPR033127 UBQ-activ_enz_E1_Cys_AS
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit
PRINTSiPR01849 UBIQUITINACT
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
TIGRFAMsiTIGR01408 Ube1, 1 hit
PROSITEiView protein in PROSITE
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1RCA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSPLSKKR RVSGSETKTG SHCSSSNSVR TELSHTPANG MAKNGNDAEI
60 70 80 90 100
DEGLYSRQLY VLGHDAMKRM QSSNVLISGL RGLGVEIAKN VILGGVKSVT
110 120 130 140 150
LHDQGVAEWK DLSSQFYLRE EDLGKNRADV SQPRLAELNS YVPVTSYTGT
160 170 180 190 200
LTNEYLTKFQ VVVLTNSSLD EQTRIGEFCH SNGIKLIVAD TRGLFGQLFC
210 220 230 240 250
DFGEEMIVFD TNGEQPLSAM ISMITKDSAG VVTCLDEARH GFESGDYVTF
260 270 280 290 300
TEVQGMTELN GCDPVEIKTL GPYTFSICDT SSFSDYVRGG IVTQVKMPKK
310 320 330 340 350
IAFKSLSSSM AEPEFLLTDF AKFDRPGQLH VGFQALHAFE KKHSRLPKPW
360 370 380 390 400
NQADADELMT LAEEVNAAQT GSAKQEELDQ AVIKKLACVA AGDLAPVNAF
410 420 430 440 450
IGGLAAQEVM KACTGKFMPI MQWLYFDALE CLPEPEEVIL TEEECAPRNC
460 470 480 490 500
RYDGQIAVFG SKLQELLAKQ RYFLVGAGAI GCELLKNFAM MGLASGEGEV
510 520 530 540 550
IVTDMDTIEK SNLNRQFLFR PWDVTKMKSE TAAAAVKQMN PSVRITGHQN
560 570 580 590 600
RVGPDTEKVY DDDFFECLDG VANALDNVDA RMYMDRRCVY YRKPLLESGT
610 620 630 640 650
LGTKGNVQVV IPFITESYSS SQDPPEKSIP ICTLKNFPNA IEHTLQWARD
660 670 680 690 700
EFEGLFKQPA ENALQYLTDS KFMERTLKLP GAQPLEVVES VYKSLVTDRP
710 720 730 740 750
RNWDDCVTWA RNHWQCQYNN NIRQLLHNFP PDQLTSSGAP FWSGPKRCPH
760 770 780 790 800
PLEFSTNNDL HMDYILAAAN LYALSYGLPS CNDRSALTKL LQDIKVPEFT
810 820 830 840 850
PKSGVKIHVS DQELQSANAS VDDSRLEELK TLLPSLEASS QFKLCPIEFE
860 870 880 890 900
KDDDTNFHMD FIVAASNLRA ENYDIPPADR HKSKLIAGKI IPAIATTTAA
910 920 930 940 950
VVGLVCLELL KIVQGHKKLE SYKNGFMNLA LPFFAFSEPI AAPKHKYYEI
960 970 980 990 1000
DWTLWDRFEV KGIQPNGEEM TLRQFLDYFK NEHKLEITML SQGVSMLYSF
1010 1020 1030 1040 1050
FMPAAKLKER LELPMTEIVT KVSKKKLGKH VKALVFELCC NDDTEEDVEV

PYVRYTIR
Length:1,058
Mass (Da):118,250
Last modified:May 3, 2011 - v1
Checksum:iA3E107042426A1D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR339046 Genomic DNA No translation available.
RefSeqiXP_005162108.1, XM_005162051.3
XP_005162109.1, XM_005162052.3
UniGeneiDr.75314

Genome annotation databases

EnsembliENSDART00000054691; ENSDARP00000054690; ENSDARG00000037559
GeneIDi406335

Similar proteinsi

Entry informationi

Entry nameiF1RCA1_DANRE
AccessioniPrimary (citable) accession number: F1RCA1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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