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Protein
Submitted name:

Uncharacterized protein

Gene

gad2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. carboxy-lyase activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid biosynthetic process Source: ZFIN
  2. neurotransmitter biosynthetic process Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_207458. GABA synthesis, release, reuptake and degradation.
REACT_223869. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:gad2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-030909-9. gad2.

Expressioni

Gene expression databases

BgeeiF1R9E8.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119205.
InParanoidiF1R9E8.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG7H1JM3.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1R9E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHGFWFLG AENAAGNGSQ SPNTPRAWCQ AAAQKFSGGI GSKLCALLNV
60 70 80 90 100
GEAEKAAQAP VKAEDESTAE SCGCNKPCNC SKATACFSDL YSTDLLPALD
110 120 130 140 150
GDAKTMNFLQ EVVDILLAYI VESFDRSTKV IDFHYPNELL QRNNWELSDE
160 170 180 190 200
PETLDDILIS CRATLKYAIK TAHPRYFNQL STGLDMVGLA ADWLTSTANT
210 220 230 240 250
NMFTYEVAPV FVLLEYVTLK KMREIIGWQD GHGDGIFSPG GAISNMYAML
260 270 280 290 300
LARYKMFPEV KEKGMSSVPR LVAFTSEHSH FSIKKGAAAL GIGTESVICI
310 320 330 340 350
KADERGKMIP SDLERRIIEA KQKGYVPFFV SATAGTTVYG AFDPLIAIAD
360 370 380 390 400
ICKKHDVWMH VDGAWGGSLL MSRKHRWKLN GVERANSMTW NPHKMMAVPL
410 420 430 440 450
QCSALLVREE GLMQSCNQMQ ACYLFQQDKH YDLQYDTGDK ALQCGRHVDI
460 470 480 490 500
FKLWLMWRAK GTIGFEAQID KCLELSEYLY NKIKDREGYQ MVFDGKPQHT
510 520 530 540 550
NVCFWYLPPG VRYLEDKVER MKRLHKVAPV IKARMMEYGT TMVSYQPQGD
560 570 580
KVNFFRMVIS NPAATFEDID FLIEEIERLG QDL
Length:583
Mass (Da):65,458
Last modified:May 3, 2011 - v1
Checksum:iCFEDA3A6F5BD51CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX530066 Genomic DNA. No translation available.
CR855137 Genomic DNA. No translation available.
RefSeqiNP_001017708.2. NM_001017708.2.
UniGeneiDr.81033.

Genome annotation databases

EnsembliENSDART00000021609; ENSDARP00000010443; ENSDARG00000015537.
GeneIDi550403.
KEGGidre:550403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX530066 Genomic DNA. No translation available.
CR855137 Genomic DNA. No translation available.
RefSeqiNP_001017708.2. NM_001017708.2.
UniGeneiDr.81033.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000021609; ENSDARP00000010443; ENSDARG00000015537.
GeneIDi550403.
KEGGidre:550403.

Organism-specific databases

CTDi2572.
ZFINiZDB-GENE-030909-9. gad2.

Phylogenomic databases

GeneTreeiENSGT00760000119205.
InParanoidiF1R9E8.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG7H1JM3.
TreeFamiTF314688.

Enzyme and pathway databases

ReactomeiREACT_207458. GABA synthesis, release, reuptake and degradation.
REACT_223869. GABA synthesis.

Miscellaneous databases

NextBioi20879652.

Gene expression databases

BgeeiF1R9E8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1R9E8_DANRE
AccessioniPrimary (citable) accession number: F1R9E8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.