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Protein
Submitted name:

Glutamate decarboxylase 2

Gene

gad2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • gamma-aminobutyric acid biosynthetic process Source: ZFIN
  • neurotransmitter biosynthetic process Source: ZFIN

Keywordsi

Molecular functionLyaseUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-888568 GABA synthesis
R-DRE-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate decarboxylase 2Imported
Gene namesi
Name:gad2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-030909-9 gad2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei394N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiF1R9E8

Expressioni

Gene expression databases

BgeeiENSDARG00000015537

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010443

Structurei

3D structure databases

SMRiF1R9E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0629 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
InParanoidiF1R9E8
KOiK01580
OMAiWRAKGTT
OrthoDBiEOG091G07ZU
TreeFamiTF314688

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

F1R9E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHGFWFLG AENAAGNGSQ SPNTPRAWCQ AAAQKFSGGI GSKLCALLNV
60 70 80 90 100
GEAEKAAQAP VKAEDESTAE SCGCNKPCNC SKATACFSDL YSTDLLPALD
110 120 130 140 150
GDAKTMNFLQ EVVDILLAYI VESFDRSTKV IDFHYPNELL QRNNWELSDE
160 170 180 190 200
PETLDDILIS CRATLKYAIK TAHPRYFNQL STGLDMVGLA ADWLTSTANT
210 220 230 240 250
NMFTYEVAPV FVLLEYVTLK KMREIIGWQD GHGDGIFSPG GAISNMYAML
260 270 280 290 300
LARYKMFPEV KEKGMSSVPR LVAFTSEHSH FSIKKGAAAL GIGTESVICI
310 320 330 340 350
KADERGKMIP SDLERRIIEA KQKGYVPFFV SATAGTTVYG AFDPLIAIAD
360 370 380 390 400
ICKKHDVWMH VDGAWGGSLL MSRKHRWKLN GVERANSMTW NPHKMMAVPL
410 420 430 440 450
QCSALLVREE GLMQSCNQMQ ACYLFQQDKH YDLQYDTGDK ALQCGRHVDI
460 470 480 490 500
FKLWLMWRAK GTIGFEAQID KCLELSEYLY NKIKDREGYQ MVFDGKPQHT
510 520 530 540 550
NVCFWYLPPG VRYLEDKVER MKRLHKVAPV IKARMMEYGT TMVSYQPQGD
560 570 580
KVNFFRMVIS NPAATFEDID FLIEEIERLG QDL
Length:583
Mass (Da):65,458
Last modified:May 3, 2011 - v1
Checksum:iCFEDA3A6F5BD51CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX530066 Genomic DNA No translation available.
CR855137 Genomic DNA No translation available.
RefSeqiNP_001017708.2, NM_001017708.2
UniGeneiDr.81033

Genome annotation databases

EnsembliENSDART00000021609; ENSDARP00000010443; ENSDARG00000015537
GeneIDi550403
KEGGidre:550403

Similar proteinsi

Entry informationi

Entry nameiF1R9E8_DANRE
AccessioniPrimary (citable) accession number: F1R9E8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health