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Protein
Submitted name:

Uncharacterized protein

Gene

pnpla6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: ZFIN
  • lysophospholipase activity Source: InterPro

GO - Biological processi

  • anterior/posterior axis specification Source: ZFIN
  • axonogenesis Source: ZFIN
  • negative regulation of BMP signaling pathway Source: ZFIN
  • neuron development Source: ZFIN
  • phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:pnpla6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-050107-4. pnpla6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 297128Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini483 – 57189Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini599 – 704106Cyclic nucleotide-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
GeneTreeiENSGT00390000002533.
KOiK14676.
OMAiQQLQGPF.
TreeFamiTF300519.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1R844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSTSDTES AEPPETDRFG NIKSLVEDQL QTSMVVGIVI GAGVVIVLIA
60 70 80 90 100
VLIFFVLRRM QLRKLEAQEV PKYRFRKRDK VLFYGRKIMR KVSQSTSSLV
110 120 130 140 150
GATSSTRPRL KKKQKMLNIA KKILRFKKEV PTLQMKEPPP SVLEADLTEF
160 170 180 190 200
DVANSHLPSE VLYMLKNVRV LGHFEKPLFL ELCKHMVFLQ FQQGEYVFRP
210 220 230 240 250
GQPDSSIYVV QDGKLELCLT GQDGKDGVVK EVYPGDSVHS LLSILDVITG
260 270 280 290 300
HQRPYKTVSA RAAEVSTVLR LPVDAFLSIF EKYPESLVRV VQIIMVRLQR
310 320 330 340 350
VTVLALHNYL GLTNELFSHE MQPRSSPLSP HPTRSSPVRH SKRFGSLTVP
360 370 380 390 400
DKHREAAVQN ATGGDHGKEG GTIPTLSRTI SMPVDIAGMQ KSLRSDFDMA
410 420 430 440 450
YERGRISVSA EDGVPAFTKE QRERKVTVDE VPSGVYLYPE EESGMDIFSS
460 470 480 490 500
FQGRPNATVF EEAQKEILRL MKIEDPSLLN GRVTFHHAKA GSVLARQGDQ
510 520 530 540 550
DVSLHFVLSG CLHVYQKMID KQEAVCLFVT QPGEMVGQLA VLTGEPLIFT
560 570 580 590 600
IKAERDCTFL KISKSEFYEI MREQPSVVLS AAHTVAIRMS AFVRQMDFAI
610 620 630 640 650
DWMAVEAGRA LYRQDDQSDC TYIVLNGRLR SVIRKANGKK ELVGEYGRGD
660 670 680 690 700
LIGVVEALTR QPRATTVHAV RDTELVKLPE GTLNNIKRRY PQVVTRLIHL
710 720 730 740 750
LGQKILGNLQ QPRGPFSSSA LGLPSMASSP DVTNPASNLS TVAVLPVCDE
760 770 780 790 800
VPINAFNLEL SHALSAIGPT LLLTSDIIRE RLGASALDSI HEYRLSGWLA
810 820 830 840 850
QQEDINRIVL YQTDSGMTPW TQRCIRQADC ILIVGLGDQE PALGELEQML
860 870 880 890 900
ENTAVRALKQ LILLHREDGP GPSRTVEWLN MRSWCSGHLH LKCPRRVFSR
910 920 930 940 950
RSPTKLREVY EKVFEKTADR HSDFSRLARV LTGNSIALVL GGGGARGCSH
960 970 980 990 1000
VGVIKAMEDT GIPIDIVGGT SIGSFIGALY AEERSAVRVK QRAREWSKAM
1010 1020 1030 1040 1050
NSVFKTVLDL TYPITSMFSG SAFNTSISKV FEDKQIEDLW LPYFNVTTDI
1060 1070 1080 1090 1100
TASAMRVHKD GSLWRYVRAS MTLSGYLPPL CDPKDGNLLM DGGYINNLPA
1110 1120 1130 1140 1150
DIARTLGTKT VIAIDVGSQD ETDLCNYGDC LSGWWLLWKR INPWAEKVKV
1160 1170 1180 1190 1200
PDMAEIQSRL AYVSCVRQLE LVKKSAYCEY IRPPIDRFKT MDFGKFDEIY
1210 1220 1230 1240 1250
DVGYQHGKLV FTEWARGDII DNMLKDHRSA DYNDSKKTDS CPCPSADFTD
1260 1270 1280 1290 1300
LAEIVSRIEP VQSYVGADEE SDYATEYEED GMDTVREEEG EEEEEEGEDP
1310 1320 1330 1340
EDQSPGEWGP NGVFPPDEDK TVRQRKNVSR DPNADFSGVS DC
Length:1,342
Mass (Da):150,025
Last modified:May 3, 2011 - v1
Checksum:iC483AAB3493B2DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX901938 Genomic DNA. No translation available.
RefSeqiXP_001921208.2. XM_001921173.4.

Genome annotation databases

EnsembliENSDART00000049716; ENSDARP00000049715; ENSDARG00000010773.
ENSDART00000140890; ENSDARP00000122326; ENSDARG00000010773.
GeneIDi560986.
KEGGidre:560986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX901938 Genomic DNA. No translation available.
RefSeqiXP_001921208.2. XM_001921173.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000049716; ENSDARP00000049715; ENSDARG00000010773.
ENSDART00000140890; ENSDARP00000122326; ENSDARG00000010773.
GeneIDi560986.
KEGGidre:560986.

Organism-specific databases

CTDi10908.
ZFINiZDB-GENE-050107-4. pnpla6.

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
GeneTreeiENSGT00390000002533.
KOiK14676.
OMAiQQLQGPF.
TreeFamiTF300519.

Enzyme and pathway databases

ReactomeiR-DRE-6814848. Glycerophospholipid catabolism.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1R844_DANRE
AccessioniPrimary (citable) accession number: F1R844
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.