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Protein
Submitted name:

Patatin-like phospholipase domain-containing 6

Gene

pnpla6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: ZFIN
  • lysophospholipase activity Source: GO_Central

GO - Biological processi

  • anterior/posterior axis specification Source: ZFIN
  • axonogenesis Source: ZFIN
  • lipid catabolic process Source: UniProtKB-UniRule
  • negative regulation of BMP signaling pathway Source: ZFIN
  • neuron development Source: ZFIN
  • phosphatidylcholine metabolic process Source: InterPro

Enzyme and pathway databases

ReactomeiR-DRE-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Patatin-like phospholipase domain-containing 6Imported
Gene namesi
Name:pnpla6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-050107-4. pnpla6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000010773.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122326.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
GeneTreeiENSGT00390000002533.
OMAiIRIFGHF.
OrthoDBiEOG091G00XM.
TreeFamiTF300519.

Family and domain databases

CDDicd00038. CAP_ED. 3 hits.
Gene3Di2.60.120.10. 3 hits.
InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. PNPLA_dom.
IPR014710. RmlC-like_jellyroll.
PfamiView protein in Pfam
PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
SMARTiView protein in SMART
SM00100. cNMP. 3 hits.
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.

Sequencei

Sequence statusi: Complete.

F1R844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSTSDTES AEPPETDRFG NIKSLVEDQL QTSMVVGIVI GAGVVIVLIA
60 70 80 90 100
VLIFFVLRRM QLRKLEAQEV PKYRFRKRDK VLFYGRKIMR KVSQSTSSLV
110 120 130 140 150
GATSSTRPRL KKKQKMLNIA KKILRFKKEV PTLQMKEPPP SVLEADLTEF
160 170 180 190 200
DVANSHLPSE VLYMLKNVRV LGHFEKPLFL ELCKHMVFLQ FQQGEYVFRP
210 220 230 240 250
GQPDSSIYVV QDGKLELCLT GQDGKDGVVK EVYPGDSVHS LLSILDVITG
260 270 280 290 300
HQRPYKTVSA RAAEVSTVLR LPVDAFLSIF EKYPESLVRV VQIIMVRLQR
310 320 330 340 350
VTVLALHNYL GLTNELFSHE MQPRSSPLSP HPTRSSPVRH SKRFGSLTVP
360 370 380 390 400
DKHREAAVQN ATGGDHGKEG GTIPTLSRTI SMPVDIAGMQ KSLRSDFDMA
410 420 430 440 450
YERGRISVSA EDGVPAFTKE QRERKVTVDE VPSGVYLYPE EESGMDIFSS
460 470 480 490 500
FQGRPNATVF EEAQKEILRL MKIEDPSLLN GRVTFHHAKA GSVLARQGDQ
510 520 530 540 550
DVSLHFVLSG CLHVYQKMID KQEAVCLFVT QPGEMVGQLA VLTGEPLIFT
560 570 580 590 600
IKAERDCTFL KISKSEFYEI MREQPSVVLS AAHTVAIRMS AFVRQMDFAI
610 620 630 640 650
DWMAVEAGRA LYRQDDQSDC TYIVLNGRLR SVIRKANGKK ELVGEYGRGD
660 670 680 690 700
LIGVVEALTR QPRATTVHAV RDTELVKLPE GTLNNIKRRY PQVVTRLIHL
710 720 730 740 750
LGQKILGNLQ QPRGPFSSSA LGLPSMASSP DVTNPASNLS TVAVLPVCDE
760 770 780 790 800
VPINAFNLEL SHALSAIGPT LLLTSDIIRE RLGASALDSI HEYRLSGWLA
810 820 830 840 850
QQEDINRIVL YQTDSGMTPW TQRCIRQADC ILIVGLGDQE PALGELEQML
860 870 880 890 900
ENTAVRALKQ LILLHREDGP GPSRTVEWLN MRSWCSGHLH LKCPRRVFSR
910 920 930 940 950
RSPTKLREVY EKVFEKTADR HSDFSRLARV LTGNSIALVL GGGGARGCSH
960 970 980 990 1000
VGVIKAMEDT GIPIDIVGGT SIGSFIGALY AEERSAVRVK QRAREWSKAM
1010 1020 1030 1040 1050
NSVFKTVLDL TYPITSMFSG SAFNTSISKV FEDKQIEDLW LPYFNVTTDI
1060 1070 1080 1090 1100
TASAMRVHKD GSLWRYVRAS MTLSGYLPPL CDPKDGNLLM DGGYINNLPA
1110 1120 1130 1140 1150
DIARTLGTKT VIAIDVGSQD ETDLCNYGDC LSGWWLLWKR INPWAEKVKV
1160 1170 1180 1190 1200
PDMAEIQSRL AYVSCVRQLE LVKKSAYCEY IRPPIDRFKT MDFGKFDEIY
1210 1220 1230 1240 1250
DVGYQHGKLV FTEWARGDII DNMLKDHRSA DYNDSKKTDS CPCPSADFTD
1260 1270 1280 1290 1300
LAEIVSRIEP VQSYVGADEE SDYATEYEED GMDTVREEEG EEEEEEGEDP
1310 1320 1330 1340
EDQSPGEWGP NGVFPPDEDK TVRQRKNVSR DPNADFSGVS DC
Length:1,342
Mass (Da):150,025
Last modified:May 3, 2011 - v1
Checksum:iC483AAB3493B2DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX901938 Genomic DNA. No translation available.
RefSeqiXP_001921208.2. XM_001921173.5.
UniGeneiDr.108408.

Genome annotation databases

EnsembliENSDART00000140890; ENSDARP00000122326; ENSDARG00000010773.
GeneIDi560986.

Similar proteinsi

Entry informationi

Entry nameiF1R844_DANRE
AccessioniPrimary (citable) accession number: F1R844
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported