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Protein

Ethylmalonyl-CoA decarboxylase

Gene

echdc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:echdc1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162721 – 302Ethylmalonyl-CoA decarboxylaseAdd BLAST302

Proteomic databases

PaxDbiF1R6N4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060189.

Structurei

3D structure databases

ProteinModelPortaliF1R6N4.
SMRiF1R6N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1680. Eukaryota.
COG1024. LUCA.
InParanoidiF1R6N4.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
InterProiView protein in InterPro
IPR029045. ClpP/crotonase-like_dom_sf.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
PfamiView protein in Pfam
PF00378. ECH_1. 1 hit.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00166. ENOYL_COA_HYDRATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F1R6N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMWGAVRCR LIQTRSAVRK ILQQNRAFCS GSSVGIREKL LAFPGGSVEL
60 70 80 90 100
QKLQESGIAV LTVSNPPARM NAFSGCMMLE LEQRVNELEI WTEGKAVIVQ
110 120 130 140 150
GAAGNFCSGS DLNAVRAIAN PHDGMKMCEF MQNTLARLLR LPLISVALVE
160 170 180 190 200
GRALGGGAEL TTACDFRLMT SDAVIQFVHK HMGLVPGWGG AARLVGIIGS
210 220 230 240 250
RNALKLLSGA RKVDPDYGKQ MGLVDEVLQC SSGEGKALAH AEHWIAPFIK
260 270 280 290 300
GPAPVIQAIK KVVVSGRELS LDEALKCERS VFGTVWGGPA NLEALASKPK

HK
Length:302
Mass (Da):32,326
Last modified:March 21, 2012 - v2
Checksum:i5E07A68444979529
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929535 Genomic DNA. No translation available.
UniGeneiDr.86450.

Similar proteinsi

Entry informationi

Entry nameiECHD1_DANRE
AccessioniPrimary (citable) accession number: F1R6N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 22, 2017
This is version 38 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families